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Sulfanilides

Organic compounds that contain a sulfonanilide group; this functional group is a type of sulfonamide consisting of a sulfur atom bonded to two oxygen atoms via double bonds, one carbon atom, and one nitrogen atom; they are derivatives of aniline.

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1 – 15 of 38 results
1

Methazolamide, MedChemExpress

MedChemExpress Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 236.27
Color White
Physical Form Solid
Chemical Name or Material Methazolamide
Grade Research
SMILES CC(/N=C1SC(S(=O)(N)=O)=NN/1C)=O
Percent Purity 99.43%
CAS 554-57-4
Solubility Information DMSO : ≥ 50 mg/mL (211.62 mM)
Health Hazard 1 H302∣H312∣H332
Synonym L584601
Purity Grade Notes Research
Recommended Storage 4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Shelf Life 4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Molecular Formula C5H8N4O3S2
Formula Weight 236.27
2

IBR2, MedChemExpress

MedChemExpress IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 400.49
Color Pink
Physical Form Solid
Chemical Name or Material IBR2
Grade Research
SMILES O=S(N1C(C2=CNC3=C2C=CC=C3)C4=C(C=CC=C4)C=C1)(CC5=CC=CC=C5)=O
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.6%
CAS 313526-24-8
Solubility Information DMSO : ≥ 100 mg/mL (249.69 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C24H20N2O2S
Formula Weight 400.49
3

TC-G-1008, MedChemExpress

MedChemExpress TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 418.9
Color White
Physical Form Solid
Chemical Name or Material TC-G-1008
Grade Research
SMILES CS(=O)(NC1=CC=C(CNC2=NC(NC)=NC(C3=NC=CC=C3)=C2)C(Cl)=C1)=O
For Use With (Application) Metabolism-protein/nucleotide metabolism
Percent Purity 99.03%
CAS 1621175-65-2
Solubility Information DMSO : ≥ 100 mg/mL (238.72 mM)
Synonym GPR39-C3
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C18H19ClN6O2S
Formula Weight 418.9
4

CZC24832, MedChemExpress

MedChemExpress CZC24832 is a highly selective and potent PI3Kγ inhibitor (IC50=27 nM) with apparent dissociation constants (Kdapp) of 19 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 364.4
Color Off-White
Physical Form Solid
Chemical Name or Material CZC24832
Grade Research
SMILES FC1=CC(C2=CC(S(=O)(NC(C)(C)C)=O)=CN=C2)=CN3C1=NC(N)=N3
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.35%
CAS 1159824-67-5
Solubility Information DMSO : ≥ 53 mg/mL (145.44 mM)
Health Hazard 1 H315∣H319∣H335
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C15H17FN6O2S
Formula Weight 364.4
5

Begacestat, MedChemExpress

MedChemExpress Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease.

ENCOMPASS_PREFERRED
6

MK-8033, MedChemExpress

MedChemExpress MK-8033 is an orally active ATP competitive c-Met/Ron dual inhibitor (IC50s: 1 nM (c-Met),7 nM (Ron)), with preferential binding to the activated kinase conformation. MK-8033 can be used in the research of cancers, such as breast and bladder cancers, non-small cell lung cancers (NSCLCs).

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 471.53
Color Light Yellow
Physical Form Solid
Chemical Name or Material MK-8033
Grade Research
SMILES O=S(NCC1=CC=CC=N1)(CC2=CC=C3C(C(C4=CC(C5=CN(N=C5)C)=CN=C4C=C3)=O)=C2)=O
For Use With (Application) Cancer-Kinase/protease
CAS 1001917-37-8
Solubility Information DMSO : ≥ 46 mg/mL (97.55 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C25H21N5O3S
Formula Weight 471.53
7

AZ876, MedChemExpress

MedChemExpress AZ876 is a potent and high-affinity LXR agonist. AZ876 displays 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 439.57
Color Orange
Physical Form Solid
Chemical Name or Material AZ876
Grade Research
SMILES O=C(C(NC1=CC=C(N2CCCCC2)C=C1)=C3C4=CC=CC=C4)N(C(C)(C)C)S3(=O)=O
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.26%
CAS 898800-26-5
Solubility Information DMSO : 100 mg/mL (227.50 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C24H29N3O3S
Formula Weight 439.57
8

CH5132799, MedChemExpress

MedChemExpress CH5132799 is a selective class I PI3K inhibitor. CH5132799 inhibits class I PI3Ks, particularly PI3Kα, with an IC50 of 14 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 377.42
Color Gray
Physical Form Solid
Chemical Name or Material CH5132799
Grade Research
SMILES NC1=NC=C(C2=C3C(N(S(=O)(C)=O)CC3)=NC(N4CCOCC4)=N2)C=N1
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.81%
CAS 1007207-67-1
Solubility Information DMSO : 4.55 mg/mL (12.06 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C15H19N7O3S
Formula Weight 377.42
9

GNE-131, MedChemExpress

MedChemExpress GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 442.57
Color Light Yellow
Physical Form Solid
Chemical Name or Material GNE-131
Grade Research
SMILES O=S(NC1=NN=C2N1C=C(C3CC3)C(OCC45C[C@@H](C6)C[C@@H](C[C@@H]6C5)C4)=C2)(C7CC7)=O
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 98.97%
CAS 1629063-81-5
Solubility Information DMSO : 125 mg/mL (282.44 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C23H30N4O3S
Formula Weight 442.57
10

Pifithrin-μ, MedChemExpress

MedChemExpress Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.

ENCOMPASS_PREFERRED
11

SR1001, MedChemExpress

MedChemExpress SR1001 is a selective RORα and RORγt inverse agonist with Kis 172 and 111 nM, respectively.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 477.4
Color Off-White
Physical Form Powder
Chemical Name or Material SR1001
Grade Research
SMILES CC(NC1=NC(C)=C(S(=O)(NC2=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C2)=O)S1)=O
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.0%
CAS 1335106-03-0
Solubility Information DMSO : ≥ 39 mg/mL (81.69 mM)
Health Hazard 1 H302∣H319
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C15H13F6N3O4S2
Formula Weight 477.4
12

Abrocitinib, MedChemExpress

MedChemExpress Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 323.41
Color Yellow
Physical Form Solid
Chemical Name or Material Abrocitinib
Grade Research
SMILES CN([C@H]1C[C@@H](NS(CCC)(=O)=O)C1)C2=C3C(NC=C3)=NC=N2
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.04%
CAS 1622902-68-4
Solubility Information DMSO : 125 mg/mL (386.51 mM; Need ultrasonic)
Health Hazard 1 H302
Synonym PF-04965842
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C14H21N5O2S
Formula Weight 323.41
13

S 3304, MedChemExpress

MedChemExpress S 3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 464.56
Color Brownish Yellow
Physical Form Powder
Chemical Name or Material S 3304
Grade Research
SMILES O=S(N[C@@H](C(O)=O)CC1=CNC2=C1C=CC=C2)(C3=CC=C(C#CC4=CC=C(C)C=C4)S3)=O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.56%
CAS 203640-27-1
Solubility Information DMSO : ≥ 83.3 mg/mL (179.31 mM)
Health Hazard 1 H302∣H315∣H319∣H335
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C24H20N2O4S2
Formula Weight 464.56
14

Brinzolamide, MedChemExpress

MedChemExpress Brinzolamide (AL-4862) is a selective carbonic anhydrase II inhibitor with anIC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide can be used in glaucoma disease research.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 383.51
Color Off-White
Physical Form Solid
Chemical Name or Material Brinzolamide
Grade Research
SMILES O=S(C(S1)=CC2=C1S(N(CCCOC)C[C@@H]2NCC)(=O)=O)(N)=O
Percent Purity 99.33%
CAS 138890-62-7
Solubility Information DMSO : 100 mg/mL (260.75 mM; Need ultrasonic)
Health Hazard 1 H302∣H315∣H319∣H335
Synonym AL-4862
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C12H21N3O5S3
Formula Weight 383.51
15

Bromosporine, MedChemExpress

MedChemExpress Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 (mu)M, 0.29 (mu)M, 0.122 (mu)M and 0.017 (mu)M for BRD2, BRD4, BRD9 and CECR2, respectively.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 404.44
Color White
Physical Form Solid
Chemical Name or Material Bromosporine
Grade Research
SMILES O=C(OCC)NC1=CC(C2=CC=C(C)C(NS(=O)(C)=O)=C2)=NN3C1=NN=C3C
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.6%
CAS 1619994-69-2
Solubility Information DMSO : ≥ 51.7 mg/mL (127.83 mM)
Health Hazard 1 H315∣H317∣H318∣H334∣H335∣H341∣H361∣H370∣H413
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C17H20N6O4S
Formula Weight 404.44