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Pyrroles

Aromatic organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that forms an amine functional group.

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1 – 15 of 184 results
1

Staurosporine, MedChemExpress

MedChemExpress Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 466.53
Color Light Yellow
Physical Form Powder
Chemical Name or Material Staurosporine
Grade Research
SMILES O=C(NC1)C2=C1C3=C(C4=C2C5=C(C=CC=C5)N4[C@H]6C[C@@H](NC)[C@@H](OC)[C@]7(C)O6)N7C8=CC=CC=C83
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.0%
CAS 62996-74-1
Solubility Information DMSO : 62.5 mg/mL (133.97 mM; Need ultrasonic)
Synonym Antibiotic AM-2282 STS AM-2282
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C28H26N4O3
Formula Weight 466.53
2

SB269652, MedChemExpress

MedChemExpress SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.

ENCOMPASS_PREFERRED
3

Apyramide, MedChemExpress

MedChemExpress Apyramide is an anti-inflammatory agent (NSAID) and behaves as a prodrug of indomethacin (HY-14397). Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 490.93
Color White
Physical Form Solid
Chemical Name or Material Apyramide
Grade Research
SMILES O=C(OC1=CC=C(NC(C)=O)C=C1)CC2=C(C)N(C(C3=CC=C(Cl)C=C3)=O)C4=C2C=C(OC)C=C4
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.06%
CAS 68483-33-0
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C27H23ClN2O5
Formula Weight 490.93
4

Oncrasin-1, MedChemExpress

MedChemExpress Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 269.73
Color Earth Yellow
Physical Form Solid
Chemical Name or Material Oncrasin-1
Grade Research
SMILES O=CC1=CN(CC(C=C2)=CC=C2Cl)C3=CC=CC=C31
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.28%
CAS 75629-57-1
Solubility Information DMSO : ≥ 43 mg/mL (159.42 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C16H12ClNO
Formula Weight 269.73
5

Vinburnine, MedChemExpress

MedChemExpress Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.

ENCOMPASS_PREFERRED
6

PCI-34051, MedChemExpress

MedChemExpress PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 296.32
Color Off-White
Physical Form Solid
Chemical Name or Material PCI-34051
Grade Research
SMILES COC(C=C1)=CC=C1CN2C3=CC(C(NO)=O)=CC=C3C=C2
For Use With (Application) Cancer-programmed cell death
Percent Purity 97.28%
CAS 950762-95-5
Solubility Information DMSO : ≥ 30 mg/mL (101.24 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C17H16N2O3
Formula Weight 296.32
7

YM-90709, MedChemExpress

MedChemExpress YM-90709 is a novel IL-5 inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R).YM-90709 potently inhibits the binding of [125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0 and 0.57 μM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 359.42
Color Orange
Physical Form Solid
Chemical Name or Material YM-90709
Grade Research
SMILES CC(CC1=CC(OC)=C(OC)C=C12)(C)N3C2=CC4=NC5=CC=CC=C5N=C43
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.52%
CAS 163769-88-8
Solubility Information DMSO : 62.5 mg/mL (173.89 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C22H21N3O2
Formula Weight 359.42
8

Entasobulin, MedChemExpress

MedChemExpress Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 439.89
Color Light Yellow
Physical Form Solid
Chemical Name or Material Entasobulin
Grade Research
SMILES O=C(C(NC1=CC(C=CC=N2)=C2C=C1)=O)C3=CN(C4=CC=CC=C43)CC5=CC=C(Cl)C=C5
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.04%
CAS 501921-61-5
Solubility Information DMSO : 155 mg/mL (352.36 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C26H18ClN3O2
Formula Weight 439.89
9

(R)-Ketorolac, MedChemExpress

MedChemExpress (R)-Ketorolac is the R-enantiomer of Ketorolac, shows potent analgesic activity, reduces ulcerogenic potential. (R)-Ketorolac is inactive on COX.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 255.27
Color Off-White
Physical Form Solid
Chemical Name or Material (R)-Ketorolac
Grade Research
SMILES O=C(C1=CC=CC=C1)C2=CC=C3N2CC[C@H]3C(O)=O
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 98.38%
CAS 66635-93-6
Solubility Information DMSO : ≥ 100 mg/mL (391.74 mM)
Health Hazard 1 H315∣H319∣H335
Synonym (+)-Ketorolac
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C15H13NO3
Formula Weight 255.27
10

LY2452473, MedChemExpress

MedChemExpress LY2452473 is an orally bioavailable, selective androgen receptor modulator (SARM).

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 374.44
Color Off-White
Physical Form Solid
Chemical Name or Material LY2452473
Grade Research
SMILES O=C(N[C@@H]1CC(N(C2=C3C=C(C=C2)C#N)CC4=NC=CC=C4)=C3C1)OC(C)C
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.13%
CAS 1029692-15-6
Solubility Information DMSO : 62.5 mg/mL (166.92 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C22H22N4O2
Formula Weight 374.44
11

AZ191, MedChemExpress

MedChemExpress AZ191 is a potent inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 429.52
Color Brown
Physical Form Solid
Chemical Name or Material AZ191
Grade Research
SMILES CN1C2=CN=CC=C2C(C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3)=C1
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.7%
CAS 1594092-37-1
Solubility Information DMSO : ≥ 30 mg/mL (69.85 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C24H27N7O
Formula Weight 429.52
12

(S)-Ketorolac, MedChemExpress

MedChemExpress (S)-Ketorolac is a nonsteroidal anti-inflammatory agent. (S)-ketorolac exhibits potent COX1 and COX2 enzyme inhibition.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 255.27
Color Off-White
Physical Form Solid
Chemical Name or Material (S)-Ketorolac
Grade Research
SMILES O=C(C1=CC=CC=C1)C2=CC=C3N2CC[C@@H]3C(O)=O
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 99.62%
CAS 66635-92-5
Solubility Information DMSO : 200 mg/mL (783.48 mM; Need ultrasonic)
Synonym (-)-Ketorolac
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C15H13NO3
Formula Weight 255.27
13

AM679, MedChemExpress

MedChemExpress AM679 is a potent, selective 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 2 nM in a human FLAP membrane binding assay. AM679 markedly reduces the respiratory syncytial virus-driven ocular pathology as well as the synthesis of cysteinyl leukotrienes (CysLTs) in the eye.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 692.87
Color pale pink
Physical Form Solid
Chemical Name or Material AM679
Grade Research
SMILES O=C(C)N1C2=CC=CC=C2C[C@H]1COC3=CC=C(N(CC4=CC=C(C5=NC=C(OC)C=N5)C=C4)C(CC(C)(C(O)=O)C)=C6SC(C)(C)C)C6=C3
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.6%
CAS 1206880-66-1
Solubility Information DMSO : ≥ 100 mg/mL (144.33 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C40H44N4O5S
Formula Weight 692.87
14

BMS-911543, MedChemExpress

MedChemExpress BMS-911543 is a selective JAK2 inhibitor, with IC50s of 1.1 nM, less selective at JAK1, JAK3 and TYK2 (IC50, 75, 360, 66 nM, respectively).

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 432.52
Color White
Physical Form Solid
Chemical Name or Material BMS-911543
Grade Research
SMILES O=C(C1=CC2=C(N(C)C=N3)C3=C(NC4=NN(C)C(C)=C4)N=C2N1CC)N(C5CC5)C6CC6
For Use With (Application) Cancer-Kinase/protease
Percent Purity 97.21%
CAS 1271022-90-2
Solubility Information DMSO : 25 mg/mL (57.80 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C23H28N8O
Formula Weight 432.52
15

Org 27569, MedChemExpress

MedChemExpress Org 27569 is a potent CB1 receptor allosteric modulator, which increases agonist binding, yet blocks agonist-induced CB1 signaling.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 409.95
Color Pink
Physical Form Solid
Chemical Name or Material Org 27569
Grade Research
SMILES ClC1=CC=C(C2=C1)NC(C(NCCC3=CC=C(C=C3)N4CCCCC4)=O)=C2CC
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 98.18%
CAS 868273-06-7
Solubility Information DMSO : ≥ 52.2 mg/mL (127.33 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C24H28ClN3O
Formula Weight 409.95