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Pyrroles

Aromatic organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that forms an amine functional group.

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1 – 15 of 184 results
1

Pevonedistat, MedChemExpress

MedChemExpress Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 443.52
Color White
Physical Form Solid
Chemical Name or Material Pevonedistat
Grade Research
SMILES O=S(OC[C@@H]1C[C@@H](N2C3=NC=NC(N[C@H]4CCC5=C4C=CC=C5)=C3C=C2)C[C@@H]1O)(N)=O
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.0%
CAS 905579-51-3
Solubility Information DMSO : 62.5 mg/mL (140.92 mM; Need ultrasonic)
Synonym MLN4924
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C21H25N5O4S
Formula Weight 443.52
2

SB269652, MedChemExpress

MedChemExpress SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.

ENCOMPASS_PREFERRED
3

KW-8232 free base, MedChemExpress

MedChemExpress KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.

ENCOMPASS_PREFERRED
4

Verdiperstat, MedChemExpress

MedChemExpress Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 253.32
Color White
Physical Form Solid
Chemical Name or Material Verdiperstat
Grade Research
SMILES O=C(N1)C(NC=C2)=C2N(CCOC(C)C)C1=S
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 99.6%
CAS 890655-80-8
Solubility Information DMSO : 150 mg/mL (592.14 mM; Need ultrasonic)
Synonym AZD3241
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C11H15N3O2S
Formula Weight 253.32
5

CMK, MedChemExpress

MedChemExpress CMK is a RSK2 kinase inhibitor which exhibits similar potency but less chemical stability compared with FMK.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 358.82
Color Light Yellow
Physical Form Solid
Chemical Name or Material CMK
Grade Research
SMILES NC1=C(C2=NC=N1)C(C3=CC=C(C=C3)C)=C(N2CCCO)C(CCl)=O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.2%
CAS 821794-90-5
Solubility Information DMSO : 150 mg/mL (418.04 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage 4°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Shelf Life 4°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Molecular Formula C18H19ClN4O2
Formula Weight 358.82
6

(R)-BPO-27, MedChemExpress

MedChemExpress (R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR inhibitor with an IC50 of 4 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 548.34
Color White
Physical Form Solid
Chemical Name or Material (R)-BPO-27
Grade Research
SMILES O=C(C1=CC=C(O[C@@H](C2=CC=C(Br)O2)C3=C(N(C)C4=O)C(C(N4C)=O)=C(C5=CC=CC=C5)N36)C6=C1)O
For Use With (Application) COVID-19-anti-virus
Percent Purity 99.86%
CAS 1415390-47-4
Solubility Information DMSO : ≥ 14.28 mg/mL (26.04 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C26H18BrN3O6
Formula Weight 548.34
7

GSK503, MedChemExpress

MedChemExpress GSK503 is a potent and specific inhibitor of EZH2 methyltransferase with Kiapp values of 3 to 27 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 526.67
Color Light Gray
Physical Form Solid
Chemical Name or Material GSK503
Grade Research
SMILES O=C(C1=CC(C2=CC=C(N3CCN(C)CC3)N=C2)=CC4=C1C(C)=CN4C(C)C)NCC5=C(C)C=C(C)NC5=O
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.73%
CAS 1346572-63-1
Solubility Information DMSO : ≥ 44 mg/mL (83.54 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C31H38N6O2
Formula Weight 526.67
8

ALB-127158(a), MedChemExpress

MedChemExpress ALB-127158(a) is a potent and selective melanin concentrating hormone 1 (MCH1) receptor antagonist.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 404.44
Color White
Physical Form Solid
Chemical Name or Material ALB-127158(a)
Grade Research
SMILES O=C1C=C(OCC2=NC=C(F)C=C2)C=CN1C3=CC4=C(C=C3)C(CNCC5)=C5N4C
For Use With (Application) Metabolism-protein/nucleotide metabolism
Percent Purity 99.6%
CAS 1173154-32-9
Solubility Information Ethanol : 2 mg/mL (4.95 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C23H21FN4O2
Formula Weight 404.44
9

Tivantinib, MedChemExpress

MedChemExpress Tivantinib is a highly selective c-Met tyrosine kinase inhibitor with a Ki of 355 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 369.42
Color Brown
Physical Form Solid
Chemical Name or Material Tivantinib
Grade Research
SMILES O=C(NC1=O)[C@@H](C2=CN3C4=C(C=CC=C42)CCC3)[C@@H]1C5=CNC6=C5C=CC=C6
For Use With (Application) Cancer-Kinase/protease
Percent Purity 96.99%
CAS 905854-02-6
Solubility Information DMSO : ≥ 100 mg/mL (270.69 mM)
Synonym ARQ 197
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C23H19N3O2
Formula Weight 369.42
10

ITX3, MedChemExpress

MedChemExpress ITX3 is a specific and nontoxic inhibitor of the TrioN (N-terminal GEF domain of the multidomain Trio protein) with IC50 of 76 uM; inhibits TrioN-stimulated RhoG exchange in vitro.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 371.45
Color Light Green
Physical Form Solid
Chemical Name or Material ITX3
Grade Research
SMILES O=C(/C1=C\C2=C(C)N(C(C)=C2)C3=CC=CC=C3)N4C(S1)=NC5=CC=CC=C45
Percent Purity 98.01%
CAS 347323-96-0
Solubility Information DMSO : 2 mg/mL (5.38 mM; ultrasonic and warming and heat to 80°C)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C22H17N3OS
Formula Weight 371.45
11

EPZ004777, MedChemExpress

MedChemExpress EPZ004777 is a potent, selective DOT1L inhibitor with an IC50 of 0.4 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 539.67
Color Off-White
Physical Form Solid
Chemical Name or Material EPZ004777
Grade Research
SMILES NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CN(C(C)C)CCCNC(NC4=CC=C(C(C)(C)C)C=C4)=O)O3)C=C2)=NC=N1
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.02%
CAS 1338466-77-5
Solubility Information DMSO : 80 mg/mL (148.24 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C28H41N7O4
Formula Weight 539.67
12

Optovin, MedChemExpress

MedChemExpress Optovin is a reversible photoactivated TRPA1 ligand that enables light-mediated neuronal excitation. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 315.41
Color Yellow
Physical Form Solid
Chemical Name or Material Optovin
Grade Research
SMILES O=C1NC(S/C1=C\C2=C(C)N(C3=CC=CN=C3)C(C)=C2)=S
Percent Purity 96.47%
CAS 348575-88-2
Solubility Information DMSO : ≥ 37 mg/mL (117.31 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C15H13N3OS2
Formula Weight 315.41
13

Forodesine, MedChemExpress

MedChemExpress Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels.

ENCOMPASS_PREFERRED
14

NVP-AEW541, MedChemExpress

MedChemExpress NVP-AEW541 (AEW541) is a potent inhibitor of IGF-1R with IC50 of 0.15 μM, also inhibits InsR, with IC50 of 0.14 μM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 439.55
Color White
Physical Form Solid
Chemical Name or Material NVP-AEW541
Grade Research
SMILES NC1=C2C(N([C@@H]3C[C@@H](C3)CN4CCC4)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.45%
CAS 475489-16-8
Solubility Information DMSO : 50 mg/mL (113.75 mM; Need ultrasonic)
Synonym AEW541
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C27H29N5O
Formula Weight 439.55
15

AZD1981, MedChemExpress

MedChemExpress AZD1981 is a potent and selective CRTh2 antagonist; displaces radio-labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8.4).

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 388.87
Color Gray
Physical Form Solid
Chemical Name or Material AZD1981
Grade Research
SMILES O=C(O)CN1C(C)=C(SC2=CC=C(Cl)C=C2)C3=C1C=CC=C3NC(C)=O
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.81%
CAS 802904-66-1
Solubility Information DMSO : ≥ 31 mg/mL (79.72 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C19H17ClN2O3S
Formula Weight 388.87