Tetrahydroisoquinolines

Organic heterocyclic compounds that consist of an isoquinoline ring with no double bonds; contains a benzene ring fused to a six-membered ring with one nitrogen atom and five carbon atoms.

1 – 15 of 66 results

Norisoboldine, MedChemExpress

MedChemExpress Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	313.35
Color	Brown
Physical Form	Solid
Chemical Name or Material	Norisoboldine
Grade	Research
SMILES	OC1=C(OC)C=C2CCN[C@@]3([H])CC4=CC(O)=C(OC)C=C4C1=C23
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.44%
CAS	23599-69-1
Solubility Information	DMSO : ≥ 62.5 mg/mL (199.46 mM)
Synonym	(+)-Laurelliptine
Purity Grade Notes	Research
Recommended Storage	4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Shelf Life	4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Molecular Formula	C₁₈H₁₉NO₄
Formula Weight	313.35

CIQ, MedChemExpress

MedChemExpress CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	467.94
Color	White
Physical Form	Solid
Chemical Name or Material	CIQ
Grade	Research
SMILES	O=C(C1=CC=CC(Cl)=C1)N2C(COC3=CC=C(OC)C=C3)C4=C(C=C(OC)C(OC)=C4)CC2
For Use With (Application)	Neuroscience-Neurodegeneration
Percent Purity	98.07%
CAS	486427-17-2
Solubility Information	DMSO : ≥ 50 mg/mL (106.85 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₆H₂₆ClNO₅
Formula Weight	467.94

(-)-Isocorypalmine, MedChemExpress

MedChemExpress (-)-Isocorypalmine (Tetrahydrocolumbamine), isolated from the crude base fraction of Corydalis chaerophylla, is a dopamine receptor ligand. Recombinant CYP719A21 displays strict substrate specificity and high affinity (Km=4.63 ± 0.71 μM) for (-)-Isocorypalmine.

Pricing and Availability

SR10067, MedChemExpress

MedChemExpress SR10067 is a potent, selective and brain penetrant Rev-Erbα/β agonist, with IC50 values are 160 and 170 nM for Rev-Erbβ and Rev-Erbα, respectively. SR10067 has anxiolytic activity.

Pricing and Availability

Lurbinectedin, MedChemExpress

MedChemExpress Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	784.87
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	Lurbinectedin
Grade	Research
SMILES	O[C@@H]([C@@](CC1=CC(C)=C2OC)([H])N(C)[C@]3([H])C1=C2O)N([C@](COC4=O)([H])C5=C(OCO6)C6=C7C)[C@@]3([H])[C@@](SC[C@@]4(NCC8)C9=C8C%10=CC(OC)=CC=C%10N9)([H])C5=C7OC(C)=O
For Use With (Application)	Cancer-programmed cell death
Percent Purity	97.13%
CAS	497871-47-3
Solubility Information	DMSO : 20 mg/mL (25.48 mM; Need ultrasonic)
Synonym	PM01183
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₄₁H₄₄N₄O₁₀S
Formula Weight	784.87

YS-49 monohydrate, MedChemExpress

MedChemExpress YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors.

Pricing and Availability
Specifications

Percent Purity	99.56%
Molecular Weight (g/mol)	404.3
Color	Gray
Physical Form	Solid
Chemical Name or Material	YS-49 monohydrate
Grade	Research
SMILES	OC1=CC2=C(C(CC3=C4C=CC=CC4=CC=C3)NCC2)C=C1O.O.Br
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
For Use With (Application)	Neuroscience-Neuromodulation
Molecular Formula	C₂₀H₂₂BrNO₃
Formula Weight	404.3

N-Nornuciferine, MedChemExpress

MedChemExpress N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and 2.34 μM, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	281.35
Color	Off-White
Physical Form	Solid
Chemical Name or Material	N-Nornuciferine
Grade	Research
SMILES	COC1=C(OC)C2=C3C(CCN[C@]3([H])CC4=CC=CC=C24)=C1
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.18%
CAS	4846-19-9
Solubility Information	DMSO : 100 mg/mL (355.43 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₈H₁₉NO₂
Formula Weight	281.35

GSK591, MedChemExpress

MedChemExpress GSK591 (EPZ015866) is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 4 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	380.48
Color	White
Physical Form	Solid
Chemical Name or Material	GSK591
Grade	Research
SMILES	O=C(C1=CC(NC2CCC2)=NC=C1)NC[C@H](O)CN3CC4=C(C=CC=C4)CC3
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.86%
CAS	1616391-87-7
Solubility Information	DMSO : ≥ 135 mg/mL (354.81 mM)
Synonym	EPZ015866 GSK3203591
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₂H₂₈N₄O₂
Formula Weight	380.48

IQ 1, MedChemExpress

MedChemExpress IQ 1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	362.42
Color	Orange
Physical Form	Solid
Chemical Name or Material	IQ 1
Grade	Research
SMILES	CC(C1=CC=C(/N=N/C(C(N)=O)=C2NC(C)(C)CC3=CC=CC=C3/2)C=C1)=O
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.69%
CAS	331001-62-8
Solubility Information	DMSO : ≥ 33 mg/mL (91.05 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₂N₄O₂
Formula Weight	362.42

NBI-98782, MedChemExpress

MedChemExpress NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	319.44
Color	White
Physical Form	Solid
Chemical Name or Material	NBI-98782
Grade	Research
SMILES	COC(C=C1CCN2C[C@@H](CC(C)C)[C@@H]3O)=C(C=C1[C@]2(C3)[H])OC
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	98.38%
CAS	85081-18-1
Solubility Information	DMSO : 33.33 mg/mL (104.34 mM; Need ultrasonic)
Synonym	(+)-DTBZ (+)-α-Dihydrotetrabenazine (+)-α-DHTBZ
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₂₉NO₃
Formula Weight	319.44

Narciclasine, MedChemExpress

MedChemExpress Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	307.26
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	Narciclasine
Grade	Research
SMILES	O=C1N[C@@]2([H])[C@H](O)[C@H](O)[C@@H](O)C=C2C3=C1C(O)=C4C(OCO4)=C3
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.06%
CAS	29477-83-6
Solubility Information	DMSO : ≥ 26 mg/mL (84.62 mM)
Health Hazard 1	H302∣H340
Synonym	Lycoricidinol
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₄H₁₃NO₇
Formula Weight	307.26

Tetrahydropalmatine, MedChemExpress

MedChemExpress Tetrahydropalmatine possesses analgesic effects. Tetrahydropalmatine acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	355.43
Color	Off-White
Physical Form	Solid
Chemical Name or Material	Tetrahydropalmatine
Grade	Research
SMILES	COC1=CC=C2C(CN3CCC4=CC(OC)=C(OC)C=C4C3C2)=C1OC
For Use With (Application)	Neuroscience-Neurodegeneration
Percent Purity	99.07%
CAS	2934-97-6
Solubility Information	DMSO : 6.67 mg/mL (18.77 mM; Need ultrasonic)
Synonym	DL-Tetrahydropalmatine
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₅NO₄
Formula Weight	355.43

NVP-CGM097 (stereoisomer), MedChemExpress

MedChemExpress NVP-CGM097 (stereoisomer) is a stereoisomer of NVP-CGM097, with no special bioactivity. NVP-CGM097 is a potent and selective MDM2 inhibitor.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	659.26
Color	Yellow
Physical Form	Solid
Chemical Name or Material	NVP-CGM097 (stereoisomer)
Grade	Research
SMILES	O=C1N(C2=CC=C(N(C)C[C@H]3CC[C@H](N4CC(N(C)CC4)=O)CC3)C=C2)[C@H](C5=CC=C(Cl)C=C5)C6=C(C=C(OC)C(OC(C)C)=C6)C1
Percent Purity	95.83%
CAS	2070009-54-8
Solubility Information	DMSO : ≥ 241.5 mg/mL (366.32 mM)
Synonym	CGM097 stereoisomer (R)-Nvp-Cgm097
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₈H₄₇ClN₄O₄
Formula Weight	659.26

(+)-Tetrabenazine, MedChemExpress

MedChemExpress (+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	317.42
Color	White
Physical Form	Solid
Chemical Name or Material	(+)-Tetrabenazine
Grade	Research
SMILES	COC1=C(OC)C=C(CCN(C[C@H]2CC(C)C)[C@]3([H])CC2=O)C3=C1
For Use With (Application)	Cancer-programmed cell death
Percent Purity	95.64%
CAS	1026016-83-0
Solubility Information	DMSO : 16.67 mg/mL (52.52 mM; Need ultrasonic)
Synonym	(+)-TBZ (3R,11bR)-TBZ (3R,11bR)-Tetrabenazine
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₂₇NO₃
Formula Weight	317.42

Laurolitsine hydrochloride, MedChemExpress

MedChemExpress Laurolitsine hydrochloride is an alkaloid isolated from Phoebe formosana, and shows weak anti-inflammatory activity.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	349.81
Color	White
Physical Form	Solid
Chemical Name or Material	Laurolitsine hydrochloride
Grade	Research
SMILES	OC1=C(OC)C2=C3C(CCN[C@@]3([H])CC4=CC(O)=C(OC)C=C24)=C1.[H]Cl
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.81%
Solubility Information	DMSO : 83 mg/mL (237.27 mM; Need ultrasonic and warming)
Synonym	(+)-Norboldine hydrochloride
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₁₈H₂₀ClNO₄
Formula Weight	349.81

Tetrahydroisoquinolines

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