Pyrroles

Aromatic organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that forms an amine functional group.

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1 – 15 of 176 results

Thermo Scientific Chemicals Atorvastatin calcium trihydrate

CAS: 344423-98-9 Molecular Formula: C66H74CaF2N4O13 Molecular Weight (g/mol): 1209.41 InChI Key: SHZPNDRIDUBNMH-NIJVSVLQSA-L IUPAC Name: calcium bis((3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate) trihydrate SMILES: O.O.O.[Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1.CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1

Pricing and Availability
Specifications

CAS	344423-98-9
Molecular Weight (g/mol)	1209.41
SMILES	O.O.O.[Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1.CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1
IUPAC Name	calcium bis((3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate) trihydrate
InChI Key	SHZPNDRIDUBNMH-NIJVSVLQSA-L
Molecular Formula	C66H74CaF2N4O13

Vinburnine, MedChemExpress

MedChemExpress Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.

Pricing and Availability

Oncrasin-1, MedChemExpress

MedChemExpress Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	269.73
Color	Earth Yellow
Physical Form	Solid
Chemical Name or Material	Oncrasin-1
Grade	Research
SMILES	O=CC1=CN(CC(C=C2)=CC=C2Cl)C3=CC=CC=C31
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.28%
CAS	75629-57-1
Solubility Information	DMSO : ≥ 43 mg/mL (159.42 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₆H₁₂ClNO
Formula Weight	269.73

Alflutinib mesylate, MedChemExpress

MedChemExpress Alflutinib (Furmonertinib) mesylate is is a potent inhibitor of EGFR. Alflutinib (Furmonertinib) mesylate inhibits EGFR active mutations as well as the T790M acquired resistant mutation. Alflutinib (Furmonertinib) mesylate has the potential for the research of cancer diseases, especially non-small cell lung cancer (NSCLC).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	664.7
Color	Yellow
Physical Form	Solid
Chemical Name or Material	Alflutinib mesylate
Grade	Research
SMILES	C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(CCN(C)C)C)=O.CS(=O)(O)=O
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.89%
CAS	2130958-55-1
Solubility Information	DMSO : 5 mg/mL (7.52 mM; Need ultrasonic)
Synonym	Furmonertinib mesylateAST2818 mesylate
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣The compound is unstable in solutions, freshly prepared is recommended.
Shelf Life	4°C, sealed storage, away from moisture∣The compound is unstable in solutions, freshly prepared is recommended.
Molecular Formula	C₂₉H₃₅F₃N₈O₅S
Formula Weight	664.7

Metergoline, MedChemExpress

MedChemExpress Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	403.52
Color	White
Physical Form	Solid
Chemical Name or Material	Metergoline
Grade	Research
SMILES	O=C(OCC1=CC=CC=C1)NC[C@H](C[C@@]23[H])CN(C)[C@]2([H])CC4=CN(C)C5=CC=CC3=C54
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	98.62%
CAS	17692-51-2
Solubility Information	DMSO : 125 mg/mL (309.77 mM; Need ultrasonic)
Health Hazard 1	H302∣H312∣H332
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₂₉N₃O₂
Formula Weight	403.52

Pevonedistat, MedChemExpress

MedChemExpress Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	443.52
Color	White
Physical Form	Solid
Chemical Name or Material	Pevonedistat
Grade	Research
SMILES	O=S(OC[C@@H]1C[C@@H](N2C3=NC=NC(N[C@H]4CCC5=C4C=CC=C5)=C3C=C2)C[C@@H]1O)(N)=O
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.0%
CAS	905579-51-3
Solubility Information	DMSO : 62.5 mg/mL (140.92 mM; Need ultrasonic)
Synonym	MLN4924
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₅N₅O₄S
Formula Weight	443.52

Staurosporine, MedChemExpress

MedChemExpress Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	466.53
Color	Light Yellow
Physical Form	Powder
Chemical Name or Material	Staurosporine
Grade	Research
SMILES	O=C(NC1)C2=C1C3=C(C4=C2C5=C(C=CC=C5)N4[C@H]6C[C@@H](NC)[C@@H](OC)[C@]7(C)O6)N7C8=CC=CC=C83
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.0%
CAS	62996-74-1
Solubility Information	DMSO : 62.5 mg/mL (133.97 mM; Need ultrasonic)
Synonym	Antibiotic AM-2282 STS AM-2282
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₈H₂₆N₄O₃
Formula Weight	466.53

RG7713, MedChemExpress

MedChemExpress RG7713 (RO5028442) is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	437.96
Color	White
Physical Form	Solid
Chemical Name or Material	RG7713
Grade	Research
SMILES	O=C(C1=CN(CCN(C)C)C2=C1C=CC(Cl)=C2)N3CCC4(C(C=CC=C5)=C5CO4)CC3
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	99.79%
CAS	920022-47-5
Solubility Information	DMSO : 20 mg/mL (45.67 mM; Need ultrasonic)
Synonym	RO5028442
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₂₈ClN₃O₂
Formula Weight	437.96

Ribociclib, MedChemExpress

MedChemExpress Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	434.54
Color	Light Yellow
Physical Form	Powder
Chemical Name or Material	Ribociclib
Grade	Research
SMILES	O=C(N(C)C)C(N1C2CCCC2)=CC(C1=N3)=CN=C3NC(N=C4)=CC=C4N5CCNCC5
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.52%
CAS	1211441-98-3
Solubility Information	DMSO : 20 mg/mL (46.03 mM; Need ultrasonic)
Synonym	LEE011
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₃H₃₀N₈O
Formula Weight	434.54

JNJ-7777120, MedChemExpress

MedChemExpress JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	277.75
Color	White
Physical Form	Solid
Chemical Name or Material	JNJ-7777120
Grade	Research
SMILES	O=C(C(N1)=CC2=C1C=CC(Cl)=C2)N3CCN(C)CC3
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.0%
CAS	459168-41-3
Solubility Information	DMSO : ≥ 50 mg/mL (180.02 mM)
Health Hazard 1	H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₄H₁₆ClN₃O
Formula Weight	277.75

Amcasertib, MedChemExpress

MedChemExpress Amcasertib (BBI503) is an orally active and small-molecule multi-kinase inhibitor. Amcasertib exhibits inhibitory activity against the NANOG and CD133 expression and cell viability in PC-9/GR cells. As an orally available cancer cell stemness kinase inhibitor with potential antineoplastic activity, it is currently being studied in phase I clinical trials in a number of cancers.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	539.69
Color	Yellow
Physical Form	Solid
Chemical Name or Material	Amcasertib
Grade	Research
SMILES	O=C(C1=C(C)NC(/C=C2C(NC3=C/2C=C(C4=CSC(C5=CC=CC=C5)=N4)C=C3)=O)=C1C)NCCN(CC)CC
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.15%
CAS	1129403-56-0
Solubility Information	DMSO : ≥ 30 mg/mL (55.59 mM)
Synonym	BBI503
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₁H₃₃N₅O₂S
Formula Weight	539.69

LY2452473, MedChemExpress

MedChemExpress LY2452473 is an orally bioavailable, selective androgen receptor modulator (SARM).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	374.44
Color	Off-White
Physical Form	Solid
Chemical Name or Material	LY2452473
Grade	Research
SMILES	O=C(N[C@@H]1CC(N(C2=C3C=C(C=C2)C#N)CC4=NC=CC=C4)=C3C1)OC(C)C
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.13%
CAS	1029692-15-6
Solubility Information	DMSO : 62.5 mg/mL (166.92 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₂H₂₂N₄O₂
Formula Weight	374.44

AZ191, MedChemExpress

MedChemExpress AZ191 is a potent inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	429.52
Color	Brown
Physical Form	Solid
Chemical Name or Material	AZ191
Grade	Research
SMILES	CN1C2=CN=CC=C2C(C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3)=C1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.7%
CAS	1594092-37-1
Solubility Information	DMSO : ≥ 30 mg/mL (69.85 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₂₇N₇O
Formula Weight	429.52

KY1220, MedChemExpress

MedChemExpress KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	314.32
Color	Yellow
Physical Form	Solid
Chemical Name or Material	KY1220
Grade	Research
SMILES	O=C(/C(N1)=C/C2=CC=CN2C3=CC=C([N+]([O-])=O)C=C3)NC1=S
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.0%
CAS	292168-79-7
Solubility Information	DMSO : ≥ 100 mg/mL (318.15 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₄H₁₀N₄O₃S
Formula Weight	314.32

GSK376501A, MedChemExpress

MedChemExpress GSK376501A is a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator for the treatment of type 2 diabetes mellitus.

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