Pyrroles

Aromatic organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that forms an amine functional group.

1 – 15 of 176 results

Thermo Scientific Chemicals Atorvastatin calcium trihydrate

CAS: 344423-98-9 Molecular Formula: C66H74CaF2N4O13 Molecular Weight (g/mol): 1209.41 InChI Key: SHZPNDRIDUBNMH-NIJVSVLQSA-L IUPAC Name: calcium bis((3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate) trihydrate SMILES: O.O.O.[Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1.CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1

Pricing and Availability
Specifications

CAS	344423-98-9
Molecular Weight (g/mol)	1209.41
SMILES	O.O.O.[Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1.CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1
IUPAC Name	calcium bis((3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate) trihydrate
InChI Key	SHZPNDRIDUBNMH-NIJVSVLQSA-L
Molecular Formula	C66H74CaF2N4O13

Vinburnine, MedChemExpress

MedChemExpress Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.

Pricing and Availability

IU1-47, MedChemExpress

MedChemExpress IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM. IU1-47 inhibits IsoT/USP5 with an IC50 of 20 μM. IU1-47 induces tau elimination in cultured neurons.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	330.85
Color	White
Physical Form	Solid
Chemical Name or Material	IU1-47
Grade	Research
SMILES	CC1=CC(C(CN2CCCCC2)=O)=C(N1C3=CC=C(C=C3)Cl)C
For Use With (Application)	Neuroscience-Neurodegeneration
Percent Purity	99.92%
CAS	670270-31-2
Solubility Information	DMSO : 16.67 mg/mL (50.39 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₂₃ClN₂O
Formula Weight	330.85

Metergoline, MedChemExpress

MedChemExpress Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	403.52
Color	White
Physical Form	Solid
Chemical Name or Material	Metergoline
Grade	Research
SMILES	O=C(OCC1=CC=CC=C1)NC[C@H](C[C@@]23[H])CN(C)[C@]2([H])CC4=CN(C)C5=CC=CC3=C54
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	98.62%
CAS	17692-51-2
Solubility Information	DMSO : 125 mg/mL (309.77 mM; Need ultrasonic)
Health Hazard 1	H302∣H312∣H332
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₂₉N₃O₂
Formula Weight	403.52

Alflutinib mesylate, MedChemExpress

MedChemExpress Alflutinib (Furmonertinib) mesylate is is a potent inhibitor of EGFR. Alflutinib (Furmonertinib) mesylate inhibits EGFR active mutations as well as the T790M acquired resistant mutation. Alflutinib (Furmonertinib) mesylate has the potential for the research of cancer diseases, especially non-small cell lung cancer (NSCLC).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	664.7
Color	Yellow
Physical Form	Solid
Chemical Name or Material	Alflutinib mesylate
Grade	Research
SMILES	C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(CCN(C)C)C)=O.CS(=O)(O)=O
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.89%
CAS	2130958-55-1
Solubility Information	DMSO : 5 mg/mL (7.52 mM; Need ultrasonic)
Synonym	Furmonertinib mesylateAST2818 mesylate
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣The compound is unstable in solutions, freshly prepared is recommended.
Shelf Life	4°C, sealed storage, away from moisture∣The compound is unstable in solutions, freshly prepared is recommended.
Molecular Formula	C₂₉H₃₅F₃N₈O₅S
Formula Weight	664.7

GSK2018682, MedChemExpress

MedChemExpress GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	440.88
Color	White
Physical Form	Solid
Chemical Name or Material	GSK2018682
Grade	Research
SMILES	O=C(O)CCCN1C=CC2=C1C=CC=C2C3=NOC(C4=CC(Cl)=C(OC(C)C)N=C4)=N3
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.25%
CAS	1034688-30-6
Solubility Information	DMSO : ≥ 125 mg/mL (283.52 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₂H₂₁ClN₄O₄
Formula Weight	440.88

EHop-016, MedChemExpress

MedChemExpress EHop-016 is a potent and selective Rac GTPase Rac1 and Rac3 inhibitor. EHop-016 inhibits Rac1 activity with an IC50 of 1.1 μM in MDA-MB-435 cells. EHop-016 inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	430.55
Color	Pink
Physical Form	Solid
Chemical Name or Material	EHop-016
Grade	Research
SMILES	CCN1C2=C(C3=C1C=CC=C3)C=C(NC4=NC(NCCCN5CCOCC5)=NC=C4)C=C2
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.43%
CAS	1380432-32-5
Solubility Information	DMSO : ≥ 32 mg/mL (74.32 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₃₀N₆O
Formula Weight	430.55

JMS-17-2, MedChemExpress

MedChemExpress JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells.

Pricing and Availability

Lestaurtinib, MedChemExpress

MedChemExpress Lestaurtinib (CEP-701) is an orally active and selective RPTKs (receptor protein tyrosine kinase) inhibitor, competitively inhibits ATP binding to the TrkA/B/C domain. Lestaurtinib inhibits RPTKs phosphorylation, with IC50s of 2, 25 and 0.9 nM for FLT3, TrkA and JAK2, respectively. Lestaurtinib induces apoptosis and cycle arrest, also can inhibit growth of tumor.

Pricing and Availability

UBCS039, MedChemExpress

MedChemExpress UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	247.29
Color	Light Yellow
Physical Form	Powder
Chemical Name or Material	UBCS039
Grade	Research
SMILES	N12C(C(C3=CC=CN=C3)NC4=C2C=CC=C4)=CC=C1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.13%
CAS	358721-70-7
Solubility Information	DMSO : 100 mg/mL (404.38 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₆H₁₃N₃
Formula Weight	247.29

Mutated EGFR-IN-1, MedChemExpress

MedChemExpress Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	445.56
Color	Pale Purple
Physical Form	Solid
Chemical Name or Material	Mutated EGFR-IN-1
Grade	Research
SMILES	NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.59%
CAS	1421372-66-8
Solubility Information	DMSO : ≥ 75 mg/mL (168.33 mM)
Synonym	Osimertinib analog
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₃₁N₇O
Formula Weight	445.56

Vincamine, MedChemExpress

MedChemExpress Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	354.44
Color	White
Physical Form	Solid
Chemical Name or Material	Vincamine
Grade	Research
SMILES	O=C(OC)[C@@]1(O)C[C@@]2(CC)[C@@]3([H])C(N1C4=CC=CC=C54)=C5CCN3CCC2
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.76%
CAS	1617-90-9
Solubility Information	DMSO : 25 mg/mL (70.53 mM; Need ultrasonic)
Health Hazard 1	H302
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₆N₂O₃
Formula Weight	354.44

MBQ-167, MedChemExpress

MedChemExpress MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	338.41
Color	Yellow
Physical Form	Solid
Chemical Name or Material	MBQ-167
Grade	Research
SMILES	CCN1C2=C(C3=C1C=CC=C3)C=C(N4N=NC=C4C5=CC=CC=C5)C=C2
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.26%
CAS	2097938-73-1
Solubility Information	DMSO : 155 mg/mL (458.02 mM; Need ultrasonic)
Health Hazard 1	H302
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₂H₁₈N₄
Formula Weight	338.41

PBOX 6, MedChemExpress

MedChemExpress PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule-depolymerizing agent and an apoptotic agent.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	396.44
Color	White
Physical Form	Solid
Chemical Name or Material	PBOX 6
Grade	Research
SMILES	O=C(OC1=C(C2=C3C=CC=CC3=CC=C2)OC4=CC=CC=C4N5C1=CC=C5)N(C)C
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.0%
CAS	290814-68-5
Solubility Information	DMSO : 33.33 mg/mL (84.07 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₂₀N₂O₃
Formula Weight	396.44

PCI-34051, MedChemExpress

MedChemExpress PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	296.32
Color	Off-White
Physical Form	Solid
Chemical Name or Material	PCI-34051
Grade	Research
SMILES	COC(C=C1)=CC=C1CN2C3=CC(C(NO)=O)=CC=C3C=C2
For Use With (Application)	Cancer-programmed cell death
Percent Purity	97.28%
CAS	950762-95-5
Solubility Information	DMSO : ≥ 30 mg/mL (101.24 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₇H₁₆N₂O₃
Formula Weight	296.32

Pyrroles

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