Pyrimidines And Derivatives

Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.

1 – 15 of 113 results

AF64394, MedChemExpress

MedChemExpress AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	393.87
Color	White
Physical Form	Solid
Chemical Name or Material	AF64394
Grade	Research
SMILES	ClC1=CC(OC(C)C)=C(CNC2=CC(C3=CC=CC=C3)=NC4=NC=NN42)C=C1
Percent Purity	98.02%
CAS	1637300-25-4
Solubility Information	DMSO : ≥ 125 mg/mL (317.36 mM)
Health Hazard 1	H302
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₀ClN₅O
Formula Weight	393.87

GDC-0349, MedChemExpress

MedChemExpress GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	452.55
Color	Yellow
Physical Form	Solid
Chemical Name or Material	GDC-0349
Grade	Research
SMILES	O=C(NCC)NC(C=C1)=CC=C1C2=NC3=C(CCN(C4COC4)C3)C(N5[C@@H](C)COCC5)=N2
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	95.0%
CAS	1207360-89-1
Solubility Information	DMSO : ≥ 100 mg/mL (220.97 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₃₂N₆O₃
Formula Weight	452.55

PF-4840154, MedChemExpress

MedChemExpress PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively. PF-4840154 elicits TrpA1-mediated nocifensive behaviour in mouse.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	466.62
Color	Off-White
Physical Form	Solid
Chemical Name or Material	PF-4840154
Grade	Research
SMILES	O=C(C1=CN=C(N2CCN(CC3COCCC3)CC2)N=C1NCC(C)C)NCC4=CC=CC=C4
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.0%
CAS	1332708-14-1
Solubility Information	DMSO : 50 mg/mL (107.15 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₆H₃₈N₆O₂
Formula Weight	466.62

MedChemExpress Pyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	248.71
Color	White
Physical Form	Solid
Chemical Name or Material	Pyrimethamine
Grade	Research
SMILES	NC1=NC(N)=C(C2=CC=C(Cl)C=C2)C(CC)=N1
For Use With (Application)	COVID-19-anti-virus
Percent Purity	99.9%
CAS	58-14-0
Solubility Information	DMSO : 20 mg/mL (80.41 mM; Need ultrasonic)
Health Hazard 1	H302
Synonym	Pirimecidan Pirimetamin RP 4753
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₂H₁₃ClN₄
Formula Weight	248.71

ALLO-2, MedChemExpress

MedChemExpress ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	371.32
Color	Yellow
Physical Form	Solid
Chemical Name or Material	ALLO-2
Grade	Research
SMILES	FC(F)(OC1=CC=C(C=C1)C2=NC(NC3=CC4=C(C=C3)NN=C4)=NC=C2)F
For Use With (Application)	Cancer-programmed cell death
Percent Purity	99.58%
CAS	1357350-60-7
Solubility Information	DMSO : 125 mg/mL (336.64 mM; Need ultrasonic)
Health Hazard 1	H302∣H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₈H₁₂F₃N₅O
Formula Weight	371.32

mTOR inhibitor-3, MedChemExpress

MedChemExpress mTOR inhibitor-3 is a remarkably selective mTOR inhibitor with a Ki of 1.5 nM. mTOR inhibitor-3 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK)/pharmacodynamic (PD) experiments.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	474.56
Color	White
Physical Form	Solid
Chemical Name or Material	mTOR inhibitor-3
Grade	Research
SMILES	O=C(NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C4C(CN(C5=NC=CC=N5)CC4)=N2)C=C1)NCC
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.58%
CAS	1207358-59-5
Solubility Information	DMSO : 50 mg/mL (105.36 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₃₀N₈O₂
Formula Weight	474.56

NIH-12848, MedChemExpress

MedChemExpress NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	385.41
Color	White
Physical Form	Solid
Chemical Name or Material	NIH-12848
Grade	Research
SMILES	FC(C1=CC=CC=C1C2=NC(NCC3=CC=CS3)=C4C=CC=CC4=N2)(F)F
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.06%
CAS	959551-10-1
Solubility Information	DMSO : ≥ 100 mg/mL (259.46 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₀H₁₄F₃N₃S
Formula Weight	385.41

Lck Inhibitor, MedChemExpress

MedChemExpress Lck Inhibitor is a potent, orally active Lck (lymphocyte specific kinase) inhibitor with IC50s of 7, 2.1, 4.2 and 200 nM for Lck, Lyn, Src and Syk kinases, respectively. Lck Inhibitor shows >1000-fold selectivity for Lck over MAPK, CDK and RSK family representatives. Lck Inhibitor inhibits T cell proliferation and in vivo models of arthritis.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	530.62
Color	Yellow
Physical Form	Solid
Chemical Name or Material	Lck Inhibitor
Grade	Research
SMILES	O=C1N(C2=C(C)C=CC=C2C)C3=NC4=CC=CC=C4N3C5=NC(NC6=CC=C(N7CCN(C)CC7)C=C6)=NC=C15
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.2%
CAS	847950-09-8
Solubility Information	DMSO : 100 mg/mL (188.46 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₁H₃₀N₈O
Formula Weight	530.62

KDM4D-IN-1, MedChemExpress

MedChemExpress KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	225.21
Color	Earth Yellow
Physical Form	Solid
Chemical Name or Material	KDM4D-IN-1
Grade	Research
SMILES	OC1=NC2=C(C#N)C(C)=NN2C3=C1C=CC=N3
For Use With (Application)	Cancer-programmed cell death
Percent Purity	99.91%
CAS	2098902-68-0
Solubility Information	DMSO : 7.14 mg/mL (31.70 mM; Need ultrasonic)
Health Hazard 1	H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₁H₇N₅O
Formula Weight	225.21

UNC2881, MedChemExpress

MedChemExpress UNC2881 is a potent and specific Mer kinase inhibitor; inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	463.58
Color	Off-White
Physical Form	Solid
Chemical Name or Material	UNC2881
Grade	Research
SMILES	CCCCNC1=NC(N[C@H]2CC[C@H](O)CC2)=C(C(NCC3=CC=C(N4C=NC=C4)C=C3)=O)C=N1
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.91%
CAS	1493764-08-1
Solubility Information	DMSO : ≥ 44 mg/mL (94.91 mM)
Health Hazard 1	H302
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₃₃N₇O₂
Formula Weight	463.58

EPZ015666, MedChemExpress

MedChemExpress EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 with an IC50 of 22 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	383.44
Color	White
Physical Form	Solid
Chemical Name or Material	EPZ015666
Grade	Research
SMILES	O=C(NC[C@H](O)CN1CCC(C=CC=C2)=C2C1)C3=CC(NC4COC4)=NC=N3
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.96%
CAS	1616391-65-1
Solubility Information	DMSO : 100 mg/mL (260.80 mM; Need ultrasonic)
Synonym	GSK3235025
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₀H₂₅N₅O₃
Formula Weight	383.44

DMH-1, MedChemExpress

MedChemExpress DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	380.44
Color	Yellow
Physical Form	Solid
Chemical Name or Material	DMH-1
Grade	Research
SMILES	CC(C)OC1=CC=C(C2=CN3C(N=C2)=C(C4=CC=NC5=CC=CC=C45)C=N3)C=C1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.58%
CAS	1206711-16-1
Solubility Information	DMSO : 11.5 mg/mL (30.23 mM; Need ultrasonic and warming)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₂₀N₄O
Formula Weight	380.44

LDN-212854, MedChemExpress

MedChemExpress LDN-212854 is a bone morphogenetic protein (BMP) inhibitor that potently inhibits ALK2 (IC50: 1.3 nM). LDN-212854 also inhibits ALK1 (IC50: 2.40 nM). LDN-212854 can be used in the research of fibrodysplasia ossificans progressive and cancers, such as hepatocellular carcinoma (HCC).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	406.48
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	LDN-212854
Grade	Research
SMILES	C12=C(C3=C4N=CC(C5=CC=C(N6CCNCC6)C=C5)=CN4N=C3)C=CC=C1N=CC=C2
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.65%
CAS	1432597-26-6
Solubility Information	DMSO : ≥ 30 mg/mL (73.80 mM)
Health Hazard 1	H301
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₂₂N₆
Formula Weight	406.48

Citarinostat, MedChemExpress

MedChemExpress Citarinostat (ACY241) is a second generation potent, orally active and high-selective HDAC6 inhibitor with an IC50 of 2.6 nM (IC50s of 35 nM, 45 nM, 46 nM and 137 nM for HDAC1, HDAC2, HDAC3 and HDAC8, respectively). Citarinostat has anticancer effects.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	467.95
Color	White
Physical Form	Solid
Chemical Name or Material	Citarinostat
Grade	Research
SMILES	O=C(C1=CN=C(N(C2=CC=CC=C2Cl)C3=CC=CC=C3)N=C1)NCCCCCCC(NO)=O
For Use With (Application)	Cancer-programmed cell death
Percent Purity	95.0%
CAS	1316215-12-9
Solubility Information	DMSO : ≥ 30 mg/mL (64.11 mM)
Synonym	ACY241
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₂₆ClN₅O₃
Formula Weight	467.95

HDACs/mTOR Inhibitor 1, MedChemExpress

MedChemExpress HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	566.65
Color	White
Physical Form	Solid
Chemical Name or Material	HDACs/mTOR Inhibitor 1
Grade	Research
SMILES	O=C(NO)CCCCCCN1C2=NC(C3=CC=C(NC(N4C[C@@H](C)OCC4)=O)C=C3)=NC(N5CCOCC5)=C2C=N1
For Use With (Application)	Neuroscience-Neurodegeneration
Percent Purity	98.21%
CAS	2271413-06-8
Solubility Information	DMSO : 32.5 mg/mL (57.35 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₈H₃₈N₈O₅
Formula Weight	566.65

Pyrimidines And Derivatives

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