Pyrimidines And Derivatives

Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.

1 – 15 of 113 results

PROTAC BET Degrader-1, MedChemExpress

MedChemExpress PROTAC BET Degrader-1 is a PROTAC connected by ligands for Cereblon and BET, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	871.9
Color	Yellow
Physical Form	Solid
Chemical Name or Material	PROTAC BET Degrader-1
Grade	Research
SMILES	CCN1C(NC2=C3C4=CC(OC)=C(C(C(C)=NO5)=C5C)C=C4NC3=NC(C(NCCCCNC(COC6=C(C(N7C(CCC8=O)C(N8)=O)=O)C(C7=O)=CC=C6)=O)=O)=N2)=CC(C9CC9)=N1
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.01%
CAS	2093386-22-0
Solubility Information	DMSO : ≥ 50 mg/mL (57.35 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₄₄H₄₅N₁₁O₉
Formula Weight	871.9

AF64394, MedChemExpress

MedChemExpress AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	393.87
Color	White
Physical Form	Solid
Chemical Name or Material	AF64394
Grade	Research
SMILES	ClC1=CC(OC(C)C)=C(CNC2=CC(C3=CC=CC=C3)=NC4=NC=NN42)C=C1
Percent Purity	98.02%
CAS	1637300-25-4
Solubility Information	DMSO : ≥ 125 mg/mL (317.36 mM)
Health Hazard 1	H302
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₀ClN₅O
Formula Weight	393.87

KDM4D-IN-1, MedChemExpress

MedChemExpress KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	225.21
Color	Earth Yellow
Physical Form	Solid
Chemical Name or Material	KDM4D-IN-1
Grade	Research
SMILES	OC1=NC2=C(C#N)C(C)=NN2C3=C1C=CC=N3
For Use With (Application)	Cancer-programmed cell death
Percent Purity	99.91%
CAS	2098902-68-0
Solubility Information	DMSO : 7.14 mg/mL (31.70 mM; Need ultrasonic)
Health Hazard 1	H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₁H₇N₅O
Formula Weight	225.21

mTOR inhibitor-3, MedChemExpress

MedChemExpress mTOR inhibitor-3 is a remarkably selective mTOR inhibitor with a Ki of 1.5 nM. mTOR inhibitor-3 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK)/pharmacodynamic (PD) experiments.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	474.56
Color	White
Physical Form	Solid
Chemical Name or Material	mTOR inhibitor-3
Grade	Research
SMILES	O=C(NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C4C(CN(C5=NC=CC=N5)CC4)=N2)C=C1)NCC
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.58%
CAS	1207358-59-5
Solubility Information	DMSO : 50 mg/mL (105.36 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₃₀N₈O₂
Formula Weight	474.56

Lck Inhibitor, MedChemExpress

MedChemExpress Lck Inhibitor is a potent, orally active Lck (lymphocyte specific kinase) inhibitor with IC50s of 7, 2.1, 4.2 and 200 nM for Lck, Lyn, Src and Syk kinases, respectively. Lck Inhibitor shows >1000-fold selectivity for Lck over MAPK, CDK and RSK family representatives. Lck Inhibitor inhibits T cell proliferation and in vivo models of arthritis.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	530.62
Color	Yellow
Physical Form	Solid
Chemical Name or Material	Lck Inhibitor
Grade	Research
SMILES	O=C1N(C2=C(C)C=CC=C2C)C3=NC4=CC=CC=C4N3C5=NC(NC6=CC=C(N7CCN(C)CC7)C=C6)=NC=C15
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.2%
CAS	847950-09-8
Solubility Information	DMSO : 100 mg/mL (188.46 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₁H₃₀N₈O
Formula Weight	530.62

DMH-1, MedChemExpress

MedChemExpress DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	380.44
Color	Yellow
Physical Form	Solid
Chemical Name or Material	DMH-1
Grade	Research
SMILES	CC(C)OC1=CC=C(C2=CN3C(N=C2)=C(C4=CC=NC5=CC=CC=C45)C=N3)C=C1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.58%
CAS	1206711-16-1
Solubility Information	DMSO : 11.5 mg/mL (30.23 mM; Need ultrasonic and warming)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₂₀N₄O
Formula Weight	380.44

NIH-12848, MedChemExpress

MedChemExpress NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	385.41
Color	White
Physical Form	Solid
Chemical Name or Material	NIH-12848
Grade	Research
SMILES	FC(C1=CC=CC=C1C2=NC(NCC3=CC=CS3)=C4C=CC=CC4=N2)(F)F
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.06%
CAS	959551-10-1
Solubility Information	DMSO : ≥ 100 mg/mL (259.46 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₀H₁₄F₃N₃S
Formula Weight	385.41

PF-4840154, MedChemExpress

MedChemExpress PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively. PF-4840154 elicits TrpA1-mediated nocifensive behaviour in mouse.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	466.62
Color	Off-White
Physical Form	Solid
Chemical Name or Material	PF-4840154
Grade	Research
SMILES	O=C(C1=CN=C(N2CCN(CC3COCCC3)CC2)N=C1NCC(C)C)NCC4=CC=CC=C4
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.0%
CAS	1332708-14-1
Solubility Information	DMSO : 50 mg/mL (107.15 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₆H₃₈N₆O₂
Formula Weight	466.62

UNC2881, MedChemExpress

MedChemExpress UNC2881 is a potent and specific Mer kinase inhibitor; inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	463.58
Color	Off-White
Physical Form	Solid
Chemical Name or Material	UNC2881
Grade	Research
SMILES	CCCCNC1=NC(N[C@H]2CC[C@H](O)CC2)=C(C(NCC3=CC=C(N4C=NC=C4)C=C3)=O)C=N1
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.91%
CAS	1493764-08-1
Solubility Information	DMSO : ≥ 44 mg/mL (94.91 mM)
Health Hazard 1	H302
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₃₃N₇O₂
Formula Weight	463.58

EPZ015666, MedChemExpress

MedChemExpress EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 with an IC50 of 22 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	383.44
Color	White
Physical Form	Solid
Chemical Name or Material	EPZ015666
Grade	Research
SMILES	O=C(NC[C@H](O)CN1CCC(C=CC=C2)=C2C1)C3=CC(NC4COC4)=NC=N3
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.96%
CAS	1616391-65-1
Solubility Information	DMSO : 100 mg/mL (260.80 mM; Need ultrasonic)
Synonym	GSK3235025
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₀H₂₅N₅O₃
Formula Weight	383.44

Pyrimethamine, MedChemExpress

MedChemExpress Pyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	248.71
Color	White
Physical Form	Solid
Chemical Name or Material	Pyrimethamine
Grade	Research
SMILES	NC1=NC(N)=C(C2=CC=C(Cl)C=C2)C(CC)=N1
For Use With (Application)	COVID-19-anti-virus
Percent Purity	99.9%
CAS	58-14-0
Solubility Information	DMSO : 20 mg/mL (80.41 mM; Need ultrasonic)
Health Hazard 1	H302
Synonym	Pirimecidan Pirimetamin RP 4753
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₂H₁₃ClN₄
Formula Weight	248.71

GDC-0349, MedChemExpress

MedChemExpress GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	452.55
Color	Yellow
Physical Form	Solid
Chemical Name or Material	GDC-0349
Grade	Research
SMILES	O=C(NCC)NC(C=C1)=CC=C1C2=NC3=C(CCN(C4COC4)C3)C(N5[C@@H](C)COCC5)=N2
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	95.0%
CAS	1207360-89-1
Solubility Information	DMSO : ≥ 100 mg/mL (220.97 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₃₂N₆O₃
Formula Weight	452.55

ALLO-2, MedChemExpress

MedChemExpress ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	371.32
Color	Yellow
Physical Form	Solid
Chemical Name or Material	ALLO-2
Grade	Research
SMILES	FC(F)(OC1=CC=C(C=C1)C2=NC(NC3=CC4=C(C=C3)NN=C4)=NC=C2)F
For Use With (Application)	Cancer-programmed cell death
Percent Purity	99.58%
CAS	1357350-60-7
Solubility Information	DMSO : 125 mg/mL (336.64 mM; Need ultrasonic)
Health Hazard 1	H302∣H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₈H₁₂F₃N₅O
Formula Weight	371.32

WAY-600, MedChemExpress

MedChemExpress WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with an IC50 of 9 nM for recombinant mTOR enzyme. WAY-600 blocks mTOR complex 1/2 (mTORC1/2) assemble and activation.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	494.59
Color	White
Physical Form	Solid
Chemical Name or Material	WAY-600
Grade	Research
SMILES	C1(C=CN2)=C2C=CC(C3=NC(N(C4CCN(CC5=CC=CN=C5)CC4)N=C6)=C6C(N7CCOCC7)=N3)=C1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	95.12%
CAS	1062159-35-6
Solubility Information	DMSO : 50 mg/mL (101.09 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₈H₃₀N₈O
Formula Weight	494.59

PRT-060318, MedChemExpress

MedChemExpress PRT-060318 (PRT318) is a novel selective inhibitor of the tyrosine kinase Syk with an IC50 of 4 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	340.42
Color	Earth Yellow
Physical Form	Solid
Chemical Name or Material	PRT-060318
Grade	Research
SMILES	O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.04%
CAS	1194961-19-7
Solubility Information	H2O : 5.6 mg/mL (16.45 mM; Need ultrasonic and warming)
Synonym	PRT318
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₈H₂₄N₆O
Formula Weight	340.42

Pyrimidines And Derivatives

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