Imidazopyridines

1 – 13 of 13 results

PDE10-IN-1, MedChemExpress

MedChemExpress PDE10-IN-1 is a potent PDE10-IN-1 inhibitor extracted from Patent WO 2013192273 A1, for treating CNS and metabolic disorders.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	369.42
Color	Earth Yellow
Physical Form	Solid
Chemical Name or Material	PDE10-IN-1
Grade	Research
SMILES	CC1=C([C@H]2[C@H](C3=NN4C(C(C)=NC=C4C)=N3)C2)N=C5C6=C(N=CC=C6)C=CN51
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	97.82%
CAS	1516896-09-5
Solubility Information	DMSO : 2 mg/mL (5.41 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₁₉N₇
Formula Weight	369.42

MedChemExpress Savolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC50 s of 5 nM and 3 nM for c-Met and p-Met, respectively. Savolitinib (AZD-6094) selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. Antineoplastic activity.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	345.36
Color	Off-White
Physical Form	Solid
Chemical Name or Material	Savolitinib
Grade	Research
SMILES	CN1N=CC(C2=CN=C3C(N([C@H](C4=CN5C(C=C4)=NC=C5)C)N=N3)=N2)=C1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.45%
CAS	1313725-88-0
Solubility Information	DMSO : 25 mg/mL (72.39 mM; Need ultrasonic)
Synonym	Volitinib HMPL-504 AZD-6094
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₇H₁₅N₉
Formula Weight	345.36

CXCR7 modulator 2, MedChemExpress

MedChemExpress CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	522.68
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	CXCR7 modulator 2
Grade	Research
SMILES	O=C([C@@H]1[C@H](O2)CC[C@H]2C1)N3CCC([C@H](CC(N)=O)N4CCCN(C5=C(CC)C=CN6C5=NC=C6)CC4)CC3
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	98.39%
CAS	2227426-37-9
Solubility Information	DMSO : 250 mg/mL (478.30 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₉H₄₂N₆O₃
Formula Weight	522.68

Dipraglurant, MedChemExpress

MedChemExpress Dipraglurant (ADX48621) is a potent, selective, orally active and brain penetrant mGluR5 negative allosteric modulator (NAM), with an IC50 of 21 nM. Dipraglurant can reduce Levodopa-induced dyskinesia (LID) in vivo.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	265.29
Color	White
Physical Form	Solid
Chemical Name or Material	Dipraglurant
Grade	Research
SMILES	FC1=CN2C(C=C1)=NC(CCC#CC3=NC=CC=C3)=C2
For Use With (Application)	Neuroscience-Neurodegeneration
Percent Purity	95.95%
CAS	872363-17-2
Solubility Information	DMSO : ≥ 40 mg/mL (150.78 mM)
Synonym	ADX48621
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₆H₁₂FN₃
Formula Weight	265.29

Soraprazan, MedChemExpress

MedChemExpress Soraprazan (BYK61359) is a selective, reversible K-competitive inhibitor of the H,K-ATPase (Ki=6.4 nM), with an IC50 of 0.19 μM in gastric glands. Soraprazan binds to the H,K-ATPase with a Kd of 28.27 nM. Soraprazan shows immediate inhibition of acid secretion and is more than 2000-fold selective for H,K-ATPase over Na,K- and Ca-ATPases.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	367.44
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	Soraprazan
Grade	Research
SMILES	O[C@@H]1[C@@H](C2=CC=CC=C2)NC3=C(C=CN4C3=NC(C)=C4C)[C@H]1OCCOC
Percent Purity	99.69%
CAS	261944-46-1
Solubility Information	DMSO : ≥ 150 mg/mL (408.23 mM)
Synonym	BYK61359
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₅N₃O₃
Formula Weight	367.44

Serabelisib, MedChemExpress

MedChemExpress Serabelisib (MLN1117) is a selective p110α inhibitor with an IC50 of 15 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	363.37
Color	Gray
Physical Form	Solid
Chemical Name or Material	Serabelisib
Grade	Research
SMILES	O=C(C1=CN=C2C=CC(C3=CC=C(OC(N)=N4)C4=C3)=CN21)N5CCOCC5
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.1%
CAS	1268454-23-4
Solubility Information	DMSO : 6.4 mg/mL (17.61 mM; Need ultrasonic and warming)
Synonym	MLN1117 INK1117 TAK-117
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₁₇N₅O₃
Formula Weight	363.37

JK184, MedChemExpress

MedChemExpress JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	350.44
Color	Pink
Physical Form	Solid
Chemical Name or Material	JK184
Grade	Research
SMILES	CC1=C(C2=CSC(NC3=CC=C(OCC)C=C3)=N2)N4C=CC=CC4=N1
For Use With (Application)	Cancer-programmed cell death
Percent Purity	99.37%
CAS	315703-52-7
Solubility Information	DMSO : ≥ 50 mg/mL (142.68 mM)
Health Hazard 1	H302∣H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₁₈N₄OS
Formula Weight	350.44

Pumaprazole, MedChemExpress

MedChemExpress Pumaprazole is a reversible proton pump antagonist.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	338.4
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	Pumaprazole
Grade	Research
SMILES	O=C(OC)NC1=CC=CC(C)=C1CNC2=CC=CN3C2=NC(C)=C3C
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.9%
CAS	158364-59-1
Solubility Information	DMSO : 100 mg/mL (295.51 mM; Need ultrasonic)
Synonym	BY-841
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₂₂N₄O₂
Formula Weight	338.4

IRAK inhibitor 1, MedChemExpress

MedChemExpress IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	293.37
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	IRAK inhibitor 1
Grade	Research
SMILES	C1(C2=CN=C3N2C=CC=C3)=CC=CC(NC4CCNCC4)=N1
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.05%
CAS	1042224-63-4
Solubility Information	DMSO : 16.67 mg/mL (56.82 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₇H₁₉N₅
Formula Weight	293.37

Linaprazan, MedChemExpress

MedChemExpress Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	366.46
Color	White
Physical Form	Solid
Chemical Name or Material	Linaprazan
Grade	Research
SMILES	O=C(C1=CN2C(C(NCC3=C(C)C=CC=C3C)=C1)=NC(C)=C2C)NCCO
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.8%
CAS	248919-64-4
Solubility Information	DMSO : ≥ 35 mg/mL (95.51 mM)
Synonym	AZD0865
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₆N₄O₂
Formula Weight	366.46

DGAT1-IN-1, MedChemExpress

MedChemExpress DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	551.56
Color	White
Physical Form	Solid
Chemical Name or Material	DGAT1-IN-1
Grade	Research
SMILES	OC(C[C@H]1CC[C@H](C2=CC=C(C3=CN4C=C(C(NCC5=CC=C(OC(F)(F)F)C=C5)=O)N=C4C=C3)C=C2)CC1)=O
For Use With (Application)	Metabolism-sugar/lipid metabolism
Percent Purity	95.0%
CAS	1449779-49-0
Solubility Information	DMSO : 20 mg/mL (36.26 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₀H₂₈F₃N₃O₄
Formula Weight	551.56

Olprinone Hydrochloride, MedChemExpress

MedChemExpress Olprinone (Loprinone) Hydrochloride is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone Hydrochloride is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	286.72
Color	Off-White
Physical Form	Solid
Chemical Name or Material	Olprinone Hydrochloride
Grade	Research
SMILES	CC(N1)=C(C=C(C#N)C1=O)C2=CN3C(C=C2)=NC=C3.[H]Cl
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.91%
CAS	119615-63-3
Solubility Information	H2O : ≥ 7.69 mg/mL (26.82 mM)
Health Hazard 1	H315∣H319∣H335
Synonym	Loprinone Hydrochloride
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₁₄H₁₁ClN₄O
Formula Weight	286.72

Antitumor agent-3, MedChemExpress

MedChemExpress Antitumor agent-3 is a potent compound which comprises a new imidazopyridine having excellent antitumor activity as an active ingredient.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	428.35
Color	Off-White
Physical Form	Solid
Chemical Name or Material	Antitumor agent-3
Grade	Research
SMILES	FC(C1=CC=C(NC2=NC(C3=C(C(F)(F)F)N=C4C=CC=CN43)=CS2)C=C1)(F)F
For Use With (Application)	Cancer-programmed cell death
Percent Purity	99.71%
CAS	420126-30-3
Solubility Information	DMSO : ≥ 59 mg/mL (137.74 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₈H₁₀F₆N₄S
Formula Weight	428.35

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