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Benzenesulfonamides

Organic compounds that consist of a benzene ring substituted with a sulfonyl group that is subsequently bonded to an amino group; considered the amide of benzenesulfonic acid.

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1 – 15 of 235 results
1

NXT629, MedChemExpress

MedChemExpress NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC50s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively. NXT629 has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 609.78
Color Light Yellow
Physical Form Solid
Chemical Name or Material NXT629
Grade Research
SMILES O=S(C1=CC=CC=C1)(NC2=CC=C(C3=CC=C(CCCC(N4CC)=NN(CC5=CC=C(C(C)(C)C)C=C5)C4=O)C=C3)N=C2)=O
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.2%
CAS 1454925-59-7
Solubility Information DMSO : 125 mg/mL (204.99 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C35H39N5O3S
Formula Weight 609.78
2

TG101209, MedChemExpress

MedChemExpress TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 509.67
Color Gray
Physical Form Solid
Chemical Name or Material TG101209
Grade Research
SMILES O=S(C1=CC=CC(NC2=NC(NC3=CC=C(C=C3)N4CCN(CC4)C)=NC=C2C)=C1)(NC(C)(C)C)=O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.81%
CAS 936091-14-4
Solubility Information DMSO : ≥ 50 mg/mL (98.10 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C26H35N7O2S
Formula Weight 509.67
3

Acetohexamide, MedChemExpress

MedChemExpress Acetohexamide is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2; stimulate the pancreas to secrete insulin.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 324.4
Color White
Physical Form Solid
Chemical Name or Material Acetohexamide
Grade Research
SMILES O=S(C1=CC=C(C(C)=O)C=C1)(NC(NC2CCCCC2)=O)=O
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.39%
CAS 968-81-0
Solubility Information DMSO : 25 mg/mL (77.07 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C15H20N2O4S
Formula Weight 324.4
4

HMN-176, MedChemExpress

MedChemExpress HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1), without significant effect on tubulin polymerization.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 382.43
Color Light Yellow
Physical Form Solid
Chemical Name or Material HMN-176
Grade Research
SMILES O=S(C1=CC=C(OC)C=C1)(NC2=CC=CC=C2/C=C/C3=CC=N(C=C3)=O)=O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.54%
CAS 173529-10-7
Solubility Information DMSO : ≥ 30 mg/mL (78.45 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C20H18N2O4S
Formula Weight 382.43
5

Alofanib, MedChemExpress

MedChemExpress Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer and antiangiogenic activity.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 413.4
Color Yellow
Physical Form Solid
Chemical Name or Material Alofanib
Grade Research
SMILES O=C(O)C1=CC=CC(S(=O)(NC2=CC(C3=CC=CN=C3)=C(C)C=C2[N+]([O-])=O)=O)=C1
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.81%
CAS 1612888-66-0
Solubility Information DMSO : ≥ 30.1 mg/mL (72.81 mM)
Synonym RPT835
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C19H15N3O6S
Formula Weight 413.4
6

L755507, MedChemExpress

MedChemExpress L755507 is a potent, selective agonist of β3-AR with an IC50 of 35 nM. L755507 enhances the homology-directed repair (HDR)-mediated genome editing in CRISPR/Cas9 nickase system.

ENCOMPASS_PREFERRED
7

LX2343, MedChemExpress

MedChemExpress LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 474.91
Color White
Physical Form Solid
Chemical Name or Material LX2343
Grade Research
SMILES O=C(NC1=CC=C(OCO2)C2=C1)CN(C3=CC(Cl)=CC=C3OC)S(=O)(C4=CC=CC=C4)=O
For Use With (Application) Neuroscience-Neurodegeneration
Percent Purity 99.74%
CAS 333745-53-2
Solubility Information DMSO : ≥ 100 mg/mL (210.57 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C22H19ClN2O6S
Formula Weight 474.91
8

SU11274, MedChemExpress

MedChemExpress SU11274 is a selective Met inhibitor with IC50 of 10 nM, but has no effects on PGDFRβ, EGFR or Tie2.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 568.09
Color Orange
Physical Form Solid
Chemical Name or Material SU11274
Grade Research
SMILES O=S(C1=CC2=C(C=C1)NC(/C2=C/C3=C(C(C(N4CCN(CC4)C)=O)=C(N3)C)C)=O)(N(C)C5=CC=CC(Cl)=C5)=O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.19%
CAS 658084-23-2
Solubility Information DMSO : ≥ 100 mg/mL (176.03 mM)
Synonym PKI-SU11274
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C28H30ClN5O4S
Formula Weight 568.09
9

Etebenecid, MedChemExpress

MedChemExpress Etebenecid is a uricosuric agents, lower uric acid levels in the body by increasing the elimination of uric acid by the kidneys, also inhibits penicillin tubular secretion.

ENCOMPASS_PREFERRED
10

Veralipride, MedChemExpress

MedChemExpress Veralipride is a D2 receptor antagonist. It is an alternative antidopaminergic treatment for menopausal symptoms.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 383.46
Color White
Physical Form Solid
Chemical Name or Material Veralipride
Grade Research
SMILES O=C(NCC1N(CC=C)CCC1)C2=CC(S(=O)(N)=O)=CC(OC)=C2OC
For Use With (Application) Neuroscience-Neurodegeneration
Percent Purity 99.57%
CAS 66644-81-3
Solubility Information DMSO : ≥ 100 mg/mL (260.78 mM)
Synonym (±)-Veralipride LIR166
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C17H25N3O5S
Formula Weight 383.46
11

Hydroxyhexamide, MedChemExpress

MedChemExpress Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 326.41
Color White
Physical Form Solid
Chemical Name or Material Hydroxyhexamide
Grade Research
SMILES O=S(C1=CC=C(C(O)C)C=C1)(NC(NC2CCCCC2)=O)=O
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.68%
CAS 3168-01-2
Solubility Information DMSO : ≥ 300 mg/mL (919.09 mM)
Synonym (±)-Hydroxyhexamid
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C15H22N2O4S
Formula Weight 326.41
12

Sulfamethoxypyridazine, MedChemExpress

MedChemExpress Sulfamethoxypyridazine is a long-acting sulfonamide antibiotic, for treatment of Dermatitis herpetiformis.

ENCOMPASS_PREFERRED
13

PKR-IN-2, MedChemExpress

MedChemExpress PKR-IN-2 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160. PKR-IN-2 can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 468.57
Color White
Physical Form Solid
Chemical Name or Material PKR-IN-2
Grade Research
SMILES N1C2C(=C(S(NC3=CC=C(C(N4CCC(O)(CC(C)C)CC4)=O)C=C3)(=O)=O)C=CC=2)N=CC=1
For Use With (Application) Cancer-Kinase/protease
Percent Purity 95.14%
CAS 1628428-01-2
Solubility Information DMSO : 50 mg/mL (106.71 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C24H28N4O4S
Formula Weight 468.57
14

PF-06471553, MedChemExpress

MedChemExpress PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 467.54
Color White
Physical Form Solid
Chemical Name or Material PF-06471553
Grade Research
SMILES O=S(C1=CC2=C(CN(C(CC3=CC=CC(OC)=C3)=O)C2)C=C1)(NC4=NN(C5CCC5)N=C4)=O
For Use With (Application) Metabolism-sugar/lipid metabolism
Percent Purity 98.18%
CAS 1808094-07-6
Solubility Information DMSO : ≥ 150 mg/mL (320.83 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C23H25N5O4S
Formula Weight 467.54
15

AZD2098, MedChemExpress

MedChemExpress AZD2098 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC50s of 7.8, 8.0, 8.0 and 7.6 for human, rat, mouse and dog respectively, used for asthma research.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 334.18
Color White
Physical Form Solid
Chemical Name or Material AZD2098
Grade Research
SMILES O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=CN=C2OC)=O
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.86%
CAS 566203-88-1
Solubility Information DMSO : 100 mg/mL (299.24 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C11H9Cl2N3O3S
Formula Weight 334.18