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Pyrimidines And Derivatives

Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.

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1 – 15 of 113 results
1

Emapunil, MedChemExpress

MedChemExpress Emapunil (AC-5216), an orally active and selective TSPO (a mitochondrial benzodiazepine receptor) ligand, produces anti-anxiety and antidepressant-like effects in various animal models.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 401.46
Color White
Physical Form Solid
Chemical Name or Material Emapunil
Grade Research
SMILES O=C(N(CC)CC1=CC=CC=C1)CN2C(N(C)C3=CN=C(C4=CC=CC=C4)N=C23)=O
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 99.26%
CAS 226954-04-7
Solubility Information DMSO : 33.33 mg/mL (83.02 mM; Need ultrasonic)
Health Hazard 1 H302
Synonym AC-5216 XBD-173
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C23H23N5O2
Formula Weight 401.46
2

AF64394, MedChemExpress

MedChemExpress AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 393.87
Color White
Physical Form Solid
Chemical Name or Material AF64394
Grade Research
SMILES ClC1=CC(OC(C)C)=C(CNC2=CC(C3=CC=CC=C3)=NC4=NC=NN42)C=C1
Percent Purity 98.02%
CAS 1637300-25-4
Solubility Information DMSO : ≥ 125 mg/mL (317.36 mM)
Health Hazard 1 H302
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C21H20ClN5O
Formula Weight 393.87
3

WAY-600, MedChemExpress

MedChemExpress WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with an IC50 of 9 nM for recombinant mTOR enzyme. WAY-600 blocks mTOR complex 1/2 (mTORC1/2) assemble and activation.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 494.59
Color White
Physical Form Solid
Chemical Name or Material WAY-600
Grade Research
SMILES C1(C=CN2)=C2C=CC(C3=NC(N(C4CCN(CC5=CC=CN=C5)CC4)N=C6)=C6C(N7CCOCC7)=N3)=C1
For Use With (Application) Cancer-Kinase/protease
Percent Purity 95.12%
CAS 1062159-35-6
Solubility Information DMSO : 50 mg/mL (101.09 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C28H30N8O
Formula Weight 494.59
4

PF-06928215, MedChemExpress

MedChemExpress PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μμ. PF-06928215 has a high binding affinity of 0.2 μM (Kd).

ENCOMPASS_PREFERRED
5

G-749, MedChemExpress

MedChemExpress G-749 is a potent, oral active and ATP competitive FLT3 inhibitor, with IC50s of 0.4 nM and 0.6 nM for FLT3 wild type and FLT3-D835Y, respectively. G-749 can be used for the research of drug resistance for acute myeloid leukemia (AML).

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 521.41
Color Off-White
Physical Form Solid
Chemical Name or Material G-749
Grade Research
SMILES O=C1C2=C(N=C(NC3CCN(C)CC3)N=C2NC4=CC=C(OC5=CC=CC=C5)C=C4)C(Br)=CN1
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.0%
CAS 1457983-28-6
Solubility Information DMSO : 25 mg/mL (47.95 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C25H25BrN6O2
Formula Weight 521.41
6

AZ20, MedChemExpress

MedChemExpress AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM, and has 8-fold selectivity against mTOR (IC50=38 nM).

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 412.51
Color Off-White
Physical Form Solid
Chemical Name or Material AZ20
Grade Research
SMILES O=S(C1(C2=CC(N3[C@H](C)COCC3)=NC(C4=CC=CC5=C4C=CN5)=N2)CC1)(C)=O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.92%
CAS 1233339-22-4
Solubility Information DMSO : ≥ 100 mg/mL (242.42 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C21H24N4O3S
Formula Weight 412.51
7

ML347, MedChemExpress

MedChemExpress ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 352.39
Color Yellow
Physical Form Solid
Chemical Name or Material ML347
Grade Research
SMILES COC1=CC=C(C2=CN3C(N=C2)=C(C4=C5C=CC=NC5=CC=C4)C=N3)C=C1
For Use With (Application) Cancer-Kinase/protease
Percent Purity 99.85%
CAS 1062368-49-3
Solubility Information DMSO : 10 mg/mL (28.38 mM; Need ultrasonic)
Synonym LDN 193719
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C22H16N4O
Formula Weight 352.39
8

PRT-060318, MedChemExpress

MedChemExpress PRT-060318 (PRT318) is a novel selective inhibitor of the tyrosine kinase Syk with an IC50 of 4 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 340.42
Color Earth Yellow
Physical Form Solid
Chemical Name or Material PRT-060318
Grade Research
SMILES O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
For Use With (Application) Cancer-Kinase/protease
Percent Purity 99.04%
CAS 1194961-19-7
Solubility Information H2O : 5.6 mg/mL (16.45 mM; Need ultrasonic and warming)
Synonym PRT318
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C18H24N6O
Formula Weight 340.42
9

EED226, MedChemExpress

MedChemExpress EED226 is a polycomb repressive complex 2 (PRC2) inhibitor, which binds to the K27me3-pocket on embryonic ectoderm development (EED) and shows strong antitumor activity in xenograft mice model. EED226 is a potent, selective, and orally bioavailable EED inhibitor. EED226 inhibits PRC2 with an IC50 of 23.4 nM when the H3K27me0 peptide is used as a substrate in the in vitro enzymatic assays.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 369.4
Color Off-White
Physical Form Solid
Chemical Name or Material EED226
Grade Research
SMILES O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.61%
CAS 2083627-02-3
Solubility Information DMSO : ≥ 29 mg/mL (78.51 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C17H15N5O3S
Formula Weight 369.4
10

GSK2334470, MedChemExpress

MedChemExpress GSK2334470 is a highly specific and potent inhibitor of PDK1 with an IC50 of 10 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 462.59
Color Light Yellow
Physical Form Solid
Chemical Name or Material GSK2334470
Grade Research
SMILES O=C([C@@H]1CN(C2=NC(NC)=NC(C3=CC4=C(C=C3)C(N)=NN4)=C2)[C@H](C)CC1)NC5CCCCC5
For Use With (Application) Cancer-Kinase/protease
Percent Purity 95.73%
CAS 1227911-45-6
Solubility Information DMSO : ≥ 50 mg/mL (108.09 mM)
Health Hazard 1 H302
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C25H34N8O
Formula Weight 462.59
11

HJB97, MedChemExpress

MedChemExpress HJB97 is a high-affinity BET inhibitor with Kis of 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively. HJB97 is employed for the design of potential PROTAC BET degrader and has antitumor activity.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 500.55
Color Yellow
Physical Form Solid
Chemical Name or Material HJB97
Grade Research
SMILES O=C(C1=NC(NC2=CC(C3CC3)=NN2CC)=C4C(NC5=C4C=C(OC)C(C6=C(C)ON=C6C)=C5)=N1)NC
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.24%
CAS 2093391-24-1
Solubility Information DMSO : 30 mg/mL (59.93 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C26H28N8O3
Formula Weight 500.55
12

VUF10460, MedChemExpress

MedChemExpress VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 269.34
Color Light Yellow
Physical Form Solid
Chemical Name or Material VUF10460
Grade Research
SMILES NC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1
For Use With (Application) COVID-19-immunoregulation
Percent Purity 98.0%
CAS 1028327-66-3
Solubility Information DMSO : 50 mg/mL (185.64 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C15H19N5
Formula Weight 269.34
13

UNC2881, MedChemExpress

MedChemExpress UNC2881 is a potent and specific Mer kinase inhibitor; inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 463.58
Color Off-White
Physical Form Solid
Chemical Name or Material UNC2881
Grade Research
SMILES CCCCNC1=NC(N[C@H]2CC[C@H](O)CC2)=C(C(NCC3=CC=C(N4C=NC=C4)C=C3)=O)C=N1
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.91%
CAS 1493764-08-1
Solubility Information DMSO : ≥ 44 mg/mL (94.91 mM)
Health Hazard 1 H302
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C25H33N7O2
Formula Weight 463.58
14

ALLO-2, MedChemExpress

MedChemExpress ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 371.32
Color Yellow
Physical Form Solid
Chemical Name or Material ALLO-2
Grade Research
SMILES FC(F)(OC1=CC=C(C=C1)C2=NC(NC3=CC4=C(C=C3)NN=C4)=NC=C2)F
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.58%
CAS 1357350-60-7
Solubility Information DMSO : 125 mg/mL (336.64 mM; Need ultrasonic)
Health Hazard 1 H302∣H315∣H319∣H335
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C18H12F3N5O
Formula Weight 371.32
15

mTOR inhibitor-3, MedChemExpress

MedChemExpress mTOR inhibitor-3 is a remarkably selective mTOR inhibitor with a Ki of 1.5 nM. mTOR inhibitor-3 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK)/pharmacodynamic (PD) experiments.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 474.56
Color White
Physical Form Solid
Chemical Name or Material mTOR inhibitor-3
Grade Research
SMILES O=C(NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C4C(CN(C5=NC=CC=N5)CC4)=N2)C=C1)NCC
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.58%
CAS 1207358-59-5
Solubility Information DMSO : 50 mg/mL (105.36 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C25H30N8O2
Formula Weight 474.56