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Piperazines

Organic heterocyclic compounds that consist of a six-membered ring with four carbon atoms and two nitrogen atoms at opposite positions in the ring.
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1 – 15 of 21 results
1

1,4-Diazabicyclo[2.2.2]octane, 97%

CAS: 280-57-9 Molecular Formula: C6H12N2 Molecular Weight (g/mol): 112.17 MDL Number: MFCD00006689 InChI Key: IMNIMPAHZVJRPE-UHFFFAOYSA-N Synonym: 1,4-diazabicyclo 2.2.2 octane,triethylenediamine,dabco,dabco 33lv,1,4-ethylenepiperazine,dabco crystal,teda,texacat td 100,dabco s-25 PubChem CID: 9237 IUPAC Name: 1,4-diazabicyclo[2.2.2]octane SMILES: C1CN2CCN1CC2

PubChem CID 9237
CAS 280-57-9
Molecular Weight (g/mol) 112.17
MDL Number MFCD00006689
SMILES C1CN2CCN1CC2
Synonym 1,4-diazabicyclo 2.2.2 octane,triethylenediamine,dabco,dabco 33lv,1,4-ethylenepiperazine,dabco crystal,teda,texacat td 100,dabco s-25
IUPAC Name 1,4-diazabicyclo[2.2.2]octane
InChI Key IMNIMPAHZVJRPE-UHFFFAOYSA-N
Molecular Formula C6H12N2
2

N-(2-Hydroxyethyl)piperazine, 98.5%

CAS: 103-76-4 Molecular Formula: C6H14N2O Molecular Weight (g/mol): 130.19 MDL Number: MFCD00005970 InChI Key: WFCSWCVEJLETKA-UHFFFAOYSA-N Synonym: n-2-hydroxyethyl piperazine,1-piperazineethanol,1-2-hydroxyethyl piperazine,hydroxyethylpiperazine,2-1-piperazinyl ethanol,2-hydroxyethylpiperazine,2-piperazinoethanol,2-piperazin-1-yl ethan-1-ol,1-piperazinethanol,4-2-hydroxyethyl piperazine PubChem CID: 7677 IUPAC Name: 2-piperazin-1-ylethanol SMILES: C1CN(CCN1)CCO

PubChem CID 7677
CAS 103-76-4
Molecular Weight (g/mol) 130.19
MDL Number MFCD00005970
SMILES C1CN(CCN1)CCO
Synonym n-2-hydroxyethyl piperazine,1-piperazineethanol,1-2-hydroxyethyl piperazine,hydroxyethylpiperazine,2-1-piperazinyl ethanol,2-hydroxyethylpiperazine,2-piperazinoethanol,2-piperazin-1-yl ethan-1-ol,1-piperazinethanol,4-2-hydroxyethyl piperazine
IUPAC Name 2-piperazin-1-ylethanol
InChI Key WFCSWCVEJLETKA-UHFFFAOYSA-N
Molecular Formula C6H14N2O
3

GLX351322, MedChemExpress

MedChemExpress GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 431.51
Color White
Physical Form Solid
Chemical Name or Material GLX351322
Grade Research
SMILES O=C(OCC)C1=C(SC2=C1CCC2)NC(CN3CCN(CC3)C(C4=CC=CO4)=O)=O
For Use With (Application) Metabolism-sugar/lipid metabolism
Percent Purity 99.94%
CAS 835598-94-2
Solubility Information DMSO : 20 mg/mL (46.35 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C21H25N3O5S
Formula Weight 431.51
4

Aspartyl-alanyl-diketopiperazine, MedChemExpress

MedChemExpress Aspartyl-alanyl-diketopiperazine (DA-DKP) is an immunomodulatory molecule generated by cleavage and cyclization from the N-terminus of human albumin and can modulate the inflammatory immune response through a molecular pathway implicated in T- lymphocyte anergy.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 186.17
Color Off-White
Physical Form Solid
Chemical Name or Material Aspartyl-alanyl-diketopiperazine
Grade Research
SMILES O=C(O)C[C@@H](C(N[C@H]1C)=O)NC1=O
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 99.44%
CAS 110954-19-3
Solubility Information DMSO : 125 mg/mL (671.43 mM; Need ultrasonic)
Synonym DA-DKP
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C7H10N2O4
Formula Weight 186.17
5

BIBF 1202, MedChemExpress

MedChemExpress BIBF 1202 is the carboxylate metabolite of BIBF 1120 which inhibits VEGFR2 kinase with an IC50 of 62 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 525.6
Color Yellow
Physical Form Solid
Chemical Name or Material BIBF 1202
Grade Research
SMILES O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 96.62%
CAS 894783-71-2
Solubility Information DMSO : ≥ 45 mg/mL (85.62 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C30H31N5O4
Formula Weight 525.6
6

(S)-ML753286, MedChemExpress

MedChemExpress (S)-ML753286 is a breast cancer resistance protein (BCRP) inhibitor with an IC50 of 0.6 μM on BCRP efflux transporter.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 355.43
Color Off-White
Physical Form Solid
Chemical Name or Material (S)-ML753286
Grade Research
SMILES COC1=CC=C2C(NC3=C2C[C@]4([H])N(C([C@H](C)NC4=O)=O)[C@H]3CC(C)C)=C1
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.62%
CAS 1699720-85-8
Solubility Information DMSO : ≥ 50 mg/mL (140.67 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C20H25N3O3
Formula Weight 355.43
7

Plinabulin, MedChemExpress

MedChemExpress Plinabulin (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells. Plinabulin binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 336.39
Color Yellow
Physical Form Solid
Chemical Name or Material Plinabulin
Grade Research
SMILES O=C(N/C1=C\C2=C(NC=N2)C(C)(C)C)/C(NC1=O)=C/C3=CC=CC=C3
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.0%
CAS 714272-27-2
Solubility Information DMSO : 50 mg/mL (148.64 mM; Need ultrasonic)
Synonym NPI-2358
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C19H20N4O2
Formula Weight 336.39
8

Nortadalafil, MedChemExpress

MedChemExpress Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 375.38
Color White
Physical Form Solid
Chemical Name or Material Nortadalafil
Grade Research
SMILES O=C1NCC(N([C@@H]1C2)[C@H](C3=CC=C(OCO4)C4=C3)C5=C2C6=C(N5)C=CC=C6)=O
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.77%
CAS 171596-36-4
Solubility Information DMSO : 50 mg/mL (133.20 mM; Need ultrasonic)
Health Hazard 1 H302∣H315∣H319∣H335
Synonym Demethyl Tadalafil
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C21H17N3O4
Formula Weight 375.38
9

Golidocitinib, MedChemExpress

MedChemExpress Golidocitinib (AZD4205) is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14.7 μM), and shows little inhibition on JAK3 (IC50>30 μM).

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 489.57
Color Yellow
Physical Form Solid
Chemical Name or Material Golidocitinib
Grade Research
SMILES C[C@@H](N1CCN(C)CC1)C(NC2=C3C(C(C4=NC(NC5=CN(C)N=C5OC)=NC=C4)=CN3)=CC=C2)=O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.0%
CAS 2091134-68-6
Solubility Information DMSO : 250 mg/mL (510.65 mM; Need ultrasonic)
Synonym AZD4205
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C25H31N9O2
Formula Weight 489.57
10

Ko 143, MedChemExpress

MedChemExpress Ko 143 is a potent and selective ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor. Ko 143 displays >200-fold selectivity over P-gp and MRP-1 transporters.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 469.57
Color White
Physical Form Solid
Chemical Name or Material Ko 143
Grade Research
SMILES O=C1N2[C@]([H])(C3=C(C[C@]2(C(N[C@H]1CCC(OC(C)(C)C)=O)=O)[H])C4=CC=C(OC)C=C4N3)CC(C)C
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.74%
CAS 461054-93-3
Solubility Information DMSO : 100 mg/mL (212.96 mM; Need ultrasonic)
Health Hazard 1 H315∣H319∣H335
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C26H35N3O5
Formula Weight 469.57
11

Ranolazine, MedChemExpress

MedChemExpress Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor. Antianginal agent.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 427.54
Color White
Physical Form Powder
Chemical Name or Material Ranolazine
Grade Research
SMILES O=C(NC1=C(C)C=CC=C1C)CN2CCN(CC(O)COC3=CC=CC=C3OC)CC2
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.72%
CAS 95635-55-5
Solubility Information DMSO : 125 mg/mL (292.37 mM; Need ultrasonic)
Health Hazard 1 H302∣H315∣H319∣H332∣H335
Synonym CVT 303 RS 43285-003
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C24H33N3O4
Formula Weight 427.54
12

Tadalafil, MedChemExpress

MedChemExpress Tadalafil (IC-351) is a PDE5 inhibitor with an IC50 value of 1.8 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 389.4
Color White
Physical Form Solid
Chemical Name or Material Tadalafil
Grade Research
SMILES O=C([C@@]1([H])CC2=C([C@@H](C3=CC=C(OCO4)C4=C3)N15)NC6=C2C=CC=C6)N(C)CC5=O
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.85%
CAS 171596-29-5
Solubility Information DMSO : ≥ 52 mg/mL (133.54 mM)
Synonym IC-351
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C22H19N3O4
Formula Weight 389.4
13

p53 and MDM2 proteins-interaction-inhibitor dihydrochloride, MedChemExpress

MedChemExpress p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is an inhibitor of the interaction between p53 and MDM2 proteins.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 807.68
Color White
Physical Form Solid
Chemical Name or Material p53 and MDM2 proteins-interaction-inhibitor dihydrochloride
Grade Research
SMILES O=C(N1CCN(CC(N2CCOCC2)=O)CC1)N3[C@](C)(C4=CC=C(Cl)C=C4)[C@](C)(C5=CC=C(Cl)C=C5)N=C3C6=CC=C(C(C)(C)C)C=C6OCC.Cl.Cl
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.79%
Solubility Information DMSO : 100 mg/mL (123.81 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula C40H51Cl4N5O4
Formula Weight 807.68
14

ML348, MedChemExpress

MedChemExpress ML348 (GNF-Pf-1127) is a selective and reversible acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 415.79
Color White
Physical Form Solid
Chemical Name or Material ML348
Grade Research
SMILES O=C(NC1=CC(C(F)(F)F)=CC=C1Cl)CN2CCN(C(C3=CC=CO3)=O)CC2
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.96%
CAS 899713-86-1
Solubility Information DMSO : 25 mg/mL (60.13 mM; Need ultrasonic)
Synonym GNF-Pf-1127
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C18H17ClF3N3O3
Formula Weight 415.79
15

p53 and MDM2 proteins-interaction-inhibitor (chiral), MedChemExpress

MedChemExpress p53 and MDM2 proteins-interaction-inhibitor (chiral) (Compound 32) is an inhibitor of the interaction between p53 and MDM2 proteins.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 734.75
Color White
Physical Form Solid
Chemical Name or Material p53 and MDM2 proteins-interaction-inhibitor (chiral)
Grade Research
SMILES O=C(N1CCN(CC(N2CCOCC2)=O)CC1)N3[C@](C)(C4=CC=C(Cl)C=C4)[C@](C)(C5=CC=C(Cl)C=C5)N=C3C6=CC=C(C(C)(C)C)C=C6OCC
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.73%
CAS 939981-37-0
Solubility Information DMSO : 50 mg/mL (68.05 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C40H49Cl2N5O4
Formula Weight 734.75