Imidazopyridines

1 – 12 of 12 results

PDE10-IN-1, MedChemExpress

MedChemExpress PDE10-IN-1 is a potent PDE10-IN-1 inhibitor extracted from Patent WO 2013192273 A1, for treating CNS and metabolic disorders.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	369.42
Color	Earth Yellow
Physical Form	Solid
Chemical Name or Material	PDE10-IN-1
Grade	Research
SMILES	CC1=C([C@H]2[C@H](C3=NN4C(C(C)=NC=C4C)=N3)C2)N=C5C6=C(N=CC=C6)C=CN51
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	97.82%
CAS	1516896-09-5
Solubility Information	DMSO : 2 mg/mL (5.41 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₁₉N₇
Formula Weight	369.42

MedChemExpress Savolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC50 s of 5 nM and 3 nM for c-Met and p-Met, respectively. Savolitinib (AZD-6094) selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. Antineoplastic activity.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	345.36
Color	Off-White
Physical Form	Solid
Chemical Name or Material	Savolitinib
Grade	Research
SMILES	CN1N=CC(C2=CN=C3C(N([C@H](C4=CN5C(C=C4)=NC=C5)C)N=N3)=N2)=C1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.45%
CAS	1313725-88-0
Solubility Information	DMSO : 25 mg/mL (72.39 mM; Need ultrasonic)
Synonym	Volitinib HMPL-504 AZD-6094
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₇H₁₅N₉
Formula Weight	345.36

CXCR7 modulator 2, MedChemExpress

MedChemExpress CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	522.68
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	CXCR7 modulator 2
Grade	Research
SMILES	O=C([C@@H]1[C@H](O2)CC[C@H]2C1)N3CCC([C@H](CC(N)=O)N4CCCN(C5=C(CC)C=CN6C5=NC=C6)CC4)CC3
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	98.39%
CAS	2227426-37-9
Solubility Information	DMSO : 250 mg/mL (478.30 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₉H₄₂N₆O₃
Formula Weight	522.68

Dipraglurant, MedChemExpress

MedChemExpress Dipraglurant (ADX48621) is a potent, selective, orally active and brain penetrant mGluR5 negative allosteric modulator (NAM), with an IC50 of 21 nM. Dipraglurant can reduce Levodopa-induced dyskinesia (LID) in vivo.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	265.29
Color	White
Physical Form	Solid
Chemical Name or Material	Dipraglurant
Grade	Research
SMILES	FC1=CN2C(C=C1)=NC(CCC#CC3=NC=CC=C3)=C2
For Use With (Application)	Neuroscience-Neurodegeneration
Percent Purity	95.95%
CAS	872363-17-2
Solubility Information	DMSO : ≥ 40 mg/mL (150.78 mM)
Synonym	ADX48621
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₆H₁₂FN₃
Formula Weight	265.29

Soraprazan, MedChemExpress

MedChemExpress Soraprazan (BYK61359) is a selective, reversible K-competitive inhibitor of the H,K-ATPase (Ki=6.4 nM), with an IC50 of 0.19 μM in gastric glands. Soraprazan binds to the H,K-ATPase with a Kd of 28.27 nM. Soraprazan shows immediate inhibition of acid secretion and is more than 2000-fold selective for H,K-ATPase over Na,K- and Ca-ATPases.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	367.44
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	Soraprazan
Grade	Research
SMILES	O[C@@H]1[C@@H](C2=CC=CC=C2)NC3=C(C=CN4C3=NC(C)=C4C)[C@H]1OCCOC
Percent Purity	99.69%
CAS	261944-46-1
Solubility Information	DMSO : ≥ 150 mg/mL (408.23 mM)
Synonym	BYK61359
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₅N₃O₃
Formula Weight	367.44

Serabelisib, MedChemExpress

MedChemExpress Serabelisib (MLN1117) is a selective p110α inhibitor with an IC50 of 15 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	363.37
Color	Gray
Physical Form	Solid
Chemical Name or Material	Serabelisib
Grade	Research
SMILES	O=C(C1=CN=C2C=CC(C3=CC=C(OC(N)=N4)C4=C3)=CN21)N5CCOCC5
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.1%
CAS	1268454-23-4
Solubility Information	DMSO : 6.4 mg/mL (17.61 mM; Need ultrasonic and warming)
Synonym	MLN1117 INK1117 TAK-117
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₁₇N₅O₃
Formula Weight	363.37

JK184, MedChemExpress

MedChemExpress JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	350.44
Color	Pink
Physical Form	Solid
Chemical Name or Material	JK184
Grade	Research
SMILES	CC1=C(C2=CSC(NC3=CC=C(OCC)C=C3)=N2)N4C=CC=CC4=N1
For Use With (Application)	Cancer-programmed cell death
Percent Purity	99.37%
CAS	315703-52-7
Solubility Information	DMSO : ≥ 50 mg/mL (142.68 mM)
Health Hazard 1	H302∣H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₁₈N₄OS
Formula Weight	350.44

Pumaprazole, MedChemExpress

MedChemExpress Pumaprazole is a reversible proton pump antagonist.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	338.4
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	Pumaprazole
Grade	Research
SMILES	O=C(OC)NC1=CC=CC(C)=C1CNC2=CC=CN3C2=NC(C)=C3C
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.9%
CAS	158364-59-1
Solubility Information	DMSO : 100 mg/mL (295.51 mM; Need ultrasonic)
Synonym	BY-841
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₂₂N₄O₂
Formula Weight	338.4

IRAK inhibitor 1, MedChemExpress

MedChemExpress IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	293.37
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	IRAK inhibitor 1
Grade	Research
SMILES	C1(C2=CN=C3N2C=CC=C3)=CC=CC(NC4CCNCC4)=N1
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.05%
CAS	1042224-63-4
Solubility Information	DMSO : 16.67 mg/mL (56.82 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₇H₁₉N₅
Formula Weight	293.37

Linaprazan, MedChemExpress

MedChemExpress Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	366.46
Color	White
Physical Form	Solid
Chemical Name or Material	Linaprazan
Grade	Research
SMILES	O=C(C1=CN2C(C(NCC3=C(C)C=CC=C3C)=C1)=NC(C)=C2C)NCCO
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.8%
CAS	248919-64-4
Solubility Information	DMSO : ≥ 35 mg/mL (95.51 mM)
Synonym	AZD0865
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₆N₄O₂
Formula Weight	366.46

DGAT1-IN-1, MedChemExpress

MedChemExpress DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	551.56
Color	White
Physical Form	Solid
Chemical Name or Material	DGAT1-IN-1
Grade	Research
SMILES	OC(C[C@H]1CC[C@H](C2=CC=C(C3=CN4C=C(C(NCC5=CC=C(OC(F)(F)F)C=C5)=O)N=C4C=C3)C=C2)CC1)=O
For Use With (Application)	Metabolism-sugar/lipid metabolism
Percent Purity	95.0%
CAS	1449779-49-0
Solubility Information	DMSO : 20 mg/mL (36.26 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₀H₂₈F₃N₃O₄
Formula Weight	551.56

Antitumor agent-3, MedChemExpress

MedChemExpress Antitumor agent-3 is a potent compound which comprises a new imidazopyridine having excellent antitumor activity as an active ingredient.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	428.35
Color	Off-White
Physical Form	Solid
Chemical Name or Material	Antitumor agent-3
Grade	Research
SMILES	FC(C1=CC=C(NC2=NC(C3=C(C(F)(F)F)N=C4C=CC=CN43)=CS2)C=C1)(F)F
For Use With (Application)	Cancer-programmed cell death
Percent Purity	99.71%
CAS	420126-30-3
Solubility Information	DMSO : ≥ 59 mg/mL (137.74 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₈H₁₀F₆N₄S
Formula Weight	428.35

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