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Tetrahydroisoquinolines

Organic heterocyclic compounds that consist of an isoquinoline ring with no double bonds; contains a benzene ring fused to a six-membered ring with one nitrogen atom and five carbon atoms.

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1

1,2,3,4-Tetrahydroisoquinoline, 97%

CAS: 91-21-4 Molecular Formula: C9H11N Molecular Weight (g/mol): 133.19 MDL Number: MFCD00006896 InChI Key: UWYZHKAOTLEWKK-UHFFFAOYSA-N Synonym: tetrahydroisoquinoline,1,2,3,4-tetrahydro-isoquinoline,isoquinoline, 1,2,3,4-tetrahydro,1,2,3,4-tetrahydro isoquinoline,1,2,3,4-tetrahydro-2-isoquinoline,1,2,3,4-tetrahydro-2-azanaphthalene,unii-56w89fbx3e,chembl14346,3,4-dihydro-1h-isoquinoline,tetrahydroisoquinolin PubChem CID: 7046 IUPAC Name: 1,2,3,4-tetrahydroisoquinoline SMILES: C1CC2=CC=CC=C2CN1

PubChem CID 7046
CAS 91-21-4
Molecular Weight (g/mol) 133.19
MDL Number MFCD00006896
SMILES C1CC2=CC=CC=C2CN1
Synonym tetrahydroisoquinoline,1,2,3,4-tetrahydro-isoquinoline,isoquinoline, 1,2,3,4-tetrahydro,1,2,3,4-tetrahydro isoquinoline,1,2,3,4-tetrahydro-2-isoquinoline,1,2,3,4-tetrahydro-2-azanaphthalene,unii-56w89fbx3e,chembl14346,3,4-dihydro-1h-isoquinoline,tetrahydroisoquinolin
IUPAC Name 1,2,3,4-tetrahydroisoquinoline
InChI Key UWYZHKAOTLEWKK-UHFFFAOYSA-N
Molecular Formula C9H11N
2

YS-49, MedChemExpress

MedChemExpress YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 386.28
Color White
Physical Form Solid
Chemical Name or Material YS-49
Grade Research
SMILES OC1=CC2=C(C(CC3=C4C=CC=CC4=CC=C3)NCC2)C=C1O.[H]Br
For Use With (Application) COVID-19-immunoregulation
Percent Purity 98.65%
CAS 132836-42-1
Solubility Information DMSO : 100 mg/mL (258.88 mM; Need ultrasonic) ∣H2O : 10 mg/mL (25.89 mM; ultrasonic and warming and heat to 60°C)
Health Hazard 1 H302
Purity Grade Notes Research
Recommended Storage 4°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Shelf Life 4°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Molecular Formula C20H20BrNO2
Formula Weight 386.28
3

Encequidar mesylate, MedChemExpress

MedChemExpress Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) is a competitive and potent P-glycoprotein inhibitor.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 784.83
Color Yellow
Physical Form Solid
Chemical Name or Material Encequidar mesylate
Grade Research
SMILES O=C(C1=CC(C2=CC=CC=C2O1)=O)NC3=CC(OC)=C(OC)C=C3C4=NN(C5=CC=C(CCN6CC7=C(C=C(OC)C(OC)=C7)CC6)C=C5)N=N4.CS(=O)(O)=O
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.68%
CAS 849675-87-2
Solubility Information DMSO : 25 mg/mL (31.85 mM; Need ultrasonic)
Synonym HM30181 mesylateHM30181A mesylate
Purity Grade Notes Research
Recommended Storage 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula C39H40N6O10S
Formula Weight 784.83
4

Ecteinascidin 770, MedChemExpress

MedChemExpress Ecteinascidin 770 (ET-770) is a 1,2,3,4-tetrahydroisoquinoline alkaloid with potent anti-cancer activities; inhibits U373MG cells with an IC50 of 4.83 nM.

ENCOMPASS_PREFERRED
5

(-)-Isocorypalmine, MedChemExpress

MedChemExpress (-)-Isocorypalmine (Tetrahydrocolumbamine), isolated from the crude base fraction of Corydalis chaerophylla, is a dopamine receptor ligand. Recombinant CYP719A21 displays strict substrate specificity and high affinity (Km=4.63 ± 0.71 μM) for (-)-Isocorypalmine.

ENCOMPASS_PREFERRED
6

YS-49 monohydrate, MedChemExpress

MedChemExpress YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors.

ENCOMPASS_PREFERRED
Percent Purity 99.56%
Molecular Weight (g/mol) 404.3
Color Gray
Physical Form Solid
Chemical Name or Material YS-49 monohydrate
Grade Research
SMILES OC1=CC2=C(C(CC3=C4C=CC=CC4=CC=C3)NCC2)C=C1O.O.Br
Purity Grade Notes Research
Recommended Storage 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
For Use With (Application) Neuroscience-Neuromodulation
Molecular Formula C20H22BrNO3
Formula Weight 404.3
7

Tetrahydroberberine, MedChemExpress

MedChemExpress Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00).

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 339.39
Color Yellow
Physical Form Solid
Chemical Name or Material Tetrahydroberberine
Grade Research
SMILES COC1=CC=C(CC23)C(CN2CCC(C3=C4)=CC5=C4OCO5)=C1OC
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 99.65%
CAS 522-97-4
Solubility Information DMSO : 25 mg/mL (73.66 mM; Need ultrasonic)
Synonym Canadine
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C20H21NO4
Formula Weight 339.39
8

Lurbinectedin, MedChemExpress

MedChemExpress Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 784.87
Color Light Yellow
Physical Form Solid
Chemical Name or Material Lurbinectedin
Grade Research
SMILES O[C@@H]([C@@](CC1=CC(C)=C2OC)([H])N(C)[C@]3([H])C1=C2O)N([C@](COC4=O)([H])C5=C(OCO6)C6=C7C)[C@@]3([H])[C@@](SC[C@@]4(NCC8)C9=C8C%10=CC(OC)=CC=C%10N9)([H])C5=C7OC(C)=O
For Use With (Application) Cancer-programmed cell death
Percent Purity 97.13%
CAS 497871-47-3
Solubility Information DMSO : 20 mg/mL (25.48 mM; Need ultrasonic)
Synonym PM01183
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C41H44N4O10S
Formula Weight 784.87
9

NVP-CGM097, MedChemExpress

MedChemExpress NVP-CGM097 is a potent and selective MDM2 inhibitor with IC50 of 1.7±0.1 nM for hMDM2.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 659.26
Color Light Yellow
Physical Form Solid
Chemical Name or Material NVP-CGM097
Grade Research
SMILES ClC(C=C1)=CC=C1[C@@H](C2=CC(OC(C)C)=C(OC)C=C2C3)N(C4=CC=C(N(C[C@@H]5CC[C@@H](N6CC(N(C)CC6)=O)CC5)C)C=C4)C3=O
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.06%
CAS 1313363-54-0
Solubility Information DMSO : ≥ 50 mg/mL (75.84 mM)
Synonym CGM097
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C38H47ClN4O4
Formula Weight 659.26
10

Bicuculline, MedChemExpress

MedChemExpress Bicuculline ((+)-Bicuculline; d-Bicuculline), as a convulsant alkaloid, is a competitive neurotransmitter GABAA receptor antagonist (IC50=2 μM). Bicuculline also blocks Ca2+-activated potassium (SK) channels and subsequently blocks the slow afterhyperpolarization (slow AHP) .

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 367.35
Color White
Physical Form Solid
Chemical Name or Material Bicuculline
Grade Research
SMILES O=C1O[C@@H]([C@H]2N(C)CCC3=C2C=C(OCO4)C4=C3)C5=CC=C(OCO6)C6=C51
Percent Purity 98.0%
CAS 485-49-4
Solubility Information DMSO : 50 mg/mL (136.11 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (insoluble)
Health Hazard 1 H300∣H311+H331∣H400
Synonym (+)-Bicuculline d-Bicuculline
Purity Grade Notes Research
Recommended Storage 4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Shelf Life 4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Molecular Formula C20H17NO6
Formula Weight 367.35
11

TCV-309 chloride, MedChemExpress

MedChemExpress TCV-309 chloride is a potent and specific platelet activating factor (PAF) antagonist. TCV-309 chloride specifically inhibits PAF-induced aggregation of rabbit and human platelets, and [3H]PAF binding to rabbit platelet microsomes with IC50 values of 33 nM, 58 nM and 27 nM, respectively. TCV-309 chloride has beneficial effects in anaphylactic shock.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 629.97
Color Yellow
Physical Form Solid
Chemical Name or Material TCV-309 chloride
Grade Research
SMILES CCC[N+]1=CC(C(N(CCC(NCCOC(N2CC3=C(C=CC=C3)CC2)=O)=O)C4=CC=CC=C4)=O)=CC(Br)=C1.[Cl-]
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.0%
CAS 121494-09-5
Solubility Information DMSO : ≥ 6.3 mg/mL (10.00 mM)
Purity Grade Notes Research
Recommended Storage 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula C30H34BrClN4O4
Formula Weight 629.97
12

Nampt-IN-1, MedChemExpress

MedChemExpress Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 419.49
Color Light Yellow
Physical Form Solid
Chemical Name or Material Nampt-IN-1
Grade Research
SMILES O=C(N1CCC(C=C(NS(CC(C)(C)O)(=O)=O)C=C2)=C2C1)COC3=CN=CC=C3
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.06%
CAS 1698878-14-6
Solubility Information DMSO : 250 mg/mL (595.96 mM; Need ultrasonic)
Synonym LSN3154567
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C20H25N3O5S
Formula Weight 419.49
13

(+)-Tetrabenazine, MedChemExpress

MedChemExpress (+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 317.42
Color White
Physical Form Solid
Chemical Name or Material (+)-Tetrabenazine
Grade Research
SMILES COC1=C(OC)C=C(CCN(C[C@H]2CC(C)C)[C@]3([H])CC2=O)C3=C1
For Use With (Application) Cancer-programmed cell death
Percent Purity 95.64%
CAS 1026016-83-0
Solubility Information DMSO : 16.67 mg/mL (52.52 mM; Need ultrasonic)
Synonym (+)-TBZ (3R,11bR)-TBZ (3R,11bR)-Tetrabenazine
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C19H27NO3
Formula Weight 317.42
14

Laurolitsine hydrochloride, MedChemExpress

MedChemExpress Laurolitsine hydrochloride is an alkaloid isolated from Phoebe formosana, and shows weak anti-inflammatory activity.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 349.81
Color White
Physical Form Solid
Chemical Name or Material Laurolitsine hydrochloride
Grade Research
SMILES OC1=C(OC)C2=C3C(CCN[C@@]3([H])CC4=CC(O)=C(OC)C=C24)=C1.[H]Cl
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.81%
Solubility Information DMSO : 83 mg/mL (237.27 mM; Need ultrasonic and warming)
Synonym (+)-Norboldine hydrochloride
Purity Grade Notes Research
Recommended Storage 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula C18H20ClNO4
Formula Weight 349.81
15

(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid, MedChemExpress

MedChemExpress (R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid is a constrained Phe analogue which can fold into a beta-bend and a helical structure, and to adopt a preferred side-chain disposition in the peptide.

ENCOMPASS_PREFERRED