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CAS RN 4449-51-8

H3C(S)HN(S)(R)CH3(R)(S)(S)(S)OH(R)H3C(S)H3CO(R)

CAS RN 4449-51-8

IUPAC Name: (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethyl-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3'H-spiro[cyclohexa[a]fluorene-9,2'-furo[3,2-b]pyridin]-3-ol
Synonyms: cyclopamine 11-deoxyjervine 11-deoxojervine 11-deoxo- (7CI) jervine jervine, 11-deoxo- (7CI)
Molecular Weight (g/mol): 411.63
Molecular Formula: C27H41NO2
InChi Key: QASFUMOKHFSJGL-LAFRSMQTSA-N
SMILES: C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C
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1 – 5 of 5 results
1

Cyclopamine, 99%

CAS: 4449-51-8 Molecular Formula: C27H41NO2 Molecular Weight (g/mol): 411.63 MDL Number: MFCD01735266 InChI Key: QASFUMOKHFSJGL-LAFRSMQTSA-N Synonym: cyclopamine,3b,23b-17,23-epoxy-11-deoxoveratraman-3-ol PubChem CID: 122130428 SMILES: C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C

PubChem CID 122130428
CAS 4449-51-8
Molecular Weight (g/mol) 411.63
MDL Number MFCD01735266
SMILES C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C
Synonym cyclopamine,3b,23b-17,23-epoxy-11-deoxoveratraman-3-ol
InChI Key QASFUMOKHFSJGL-LAFRSMQTSA-N
Molecular Formula C27H41NO2
2

Cyclopamine, TRC

CAS: 4449-51-8 Molecular Formula: C27 H41 N O2 Molecular Weight (g/mol): 411.62 Synonym: Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-,Cyclopamine (8CI),Jervine, 11-deoxo- (7CI),Veratraman-3-ol, 17,23-epoxy-, (3β,23β)-,(-)-Cyclopamine,11-Deoxojervine,11-Deoxyjervine IUPAC Name: (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol SMILES: C[C@@H]1CN[C@@H]2[C@@H](C1)O[C@]3(CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C)[C@@H]2C

CAS 4449-51-8
Molecular Weight (g/mol) 411.62
SMILES C[C@@H]1CN[C@@H]2[C@@H](C1)O[C@]3(CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C)[C@@H]2C
Synonym Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-,Cyclopamine (8CI),Jervine, 11-deoxo- (7CI),Veratraman-3-ol, 17,23-epoxy-, (3β,23β)-,(-)-Cyclopamine,11-Deoxojervine,11-Deoxyjervine
IUPAC Name (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
Molecular Formula C27 H41 N O2
3

Tocris Bioscience™ Cyclopamine
GREENER_CHOICE

4

STEMCELL Technologies Cyclopamine

Hedgehog pathway inhibitor; Inhibits Smoothened (SMO)

ENCOMPASS_PREFERRED
CAS 4449-51-8
Purity ≥95%
Synonym 11-Deoxojervine; Jervine
Molecular Formula C27H41NO2
5

Cyclopamine, MedChemExpress

MedChemExpress Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 411.62
Color White
Physical Form Solid
Chemical Name or Material Cyclopamine
Grade Research
SMILES CC1=C2[C@@]([C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=CC3)C)([H])C2)([H])CC[C@@]15[C@@H]([C@@]6([H])[C@](C[C@H](C)CN6)([H])O5)C
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.0%
CAS 4449-51-8
Solubility Information Ethanol : 20 mg/mL (48.59 mM; Need ultrasonic) ∣DMSO : 10 mg/mL (24.29 mM; ultrasonic and warming and heat to 80°C)
Synonym 11-Deoxojervine
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C27H41NO2
Formula Weight 411.62