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  5. STEMCELL Technologies Cyclopamine

STEMCELL Technologies Cyclopamine

Product Code. 17130022
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5 mg
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Product Code. 17130022 Supplier STEMCELL Technologies Supplier No. 72074

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Description

Hedgehog pathway inhibitor; Inhibits Smoothened (SMO)

  • Cyclopamine is a steroid alkaloid that inhibits the Hedgehog pathway at the point of the pathway activator Smoothened
  • Cyclopamine binds to the heptahelical bundle of Smoothened, a G protein-coupled receptor, and prevents it from signaling further downstream (Chen et al.)
  • Reduces proliferation of rat neural progenitor cells and mouse neurospheres (Lai et al.; Palma and Ruiz i Altaba)
  • Reduces proliferation of mouse mammospheres (Liu et al.)
  • Promotes differentiation of pancreatic cells from human embryonic stem cells (D'Amour et al.)
  • Inhibits the growth of human and mouse medulloblastoma cells, and human glioblastoma cells (Bar et al.), Berman et al.)

Specifications

CAS 4449-51-8
Synonym 11-Deoxojervine; Jervine
Quantity 5 mg
Molecular Formula C27H41NO2
Purity ≥95%
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