Tetracarboxylic acids and derivatives

1 – 9 of 9 results

SGC3027, MedChemExpress

MedChemExpress SGC3027 is a histone methyltransferase inhibitor. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7.

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EDO-S101, MedChemExpress

MedChemExpress EDO-S101 (Tinostamustine) is a pan HDAC inhibitor; inhibits HDAC6, HDAC1, HDAC2 and HDAC3 with IC50 values of 6 nM, 9 nM, 9 nM and 25 nM, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	415.36
Color	Off-White
Physical Form	Solid
Chemical Name or Material	EDO-S101
Grade	Research
SMILES	O=C(NO)CCCCCCC1=NC2=CC(N(CCCl)CCCl)=CC=C2N1C
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.0%
CAS	1236199-60-2
Solubility Information	DMSO : 100 mg/mL (240.76 mM; Need ultrasonic)
Synonym	Tinostamustine
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₂₈Cl₂N₄O₂
Formula Weight	415.36

EGTA-AM, MedChemExpress

MedChemExpress EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca2+ chelator with slow chelating dynamics.

Pricing and Availability

MedChemExpress BAPTA-AM is a well-known membrane permeable Ca2+ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	764.68
Color	Off-White
Physical Form	Solid
Chemical Name or Material	BAPTA-AM
Grade	Research
SMILES	O=C(OCOC(C)=O)CN(C(C=CC=C1)=C1OCCOC(C=CC=C2)=C2N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O
Percent Purity	98.38%
CAS	126150-97-8
Solubility Information	DMSO : 50 mg/mL (65.39 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic) (insoluble)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₄H₄₀N₂O₁₈
Formula Weight	764.68

(+)-JQ-1, MedChemExpress

MedChemExpress (+)-JQ-1 (JQ1) is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)). (+)-JQ-1 also activates autophagy.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	456.99
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	(+)-JQ-1
Grade	Research
SMILES	O=C(C[C@H]1C2=NN=C(N2C3=C(C(C4=CC=C(C=C4)Cl)=N1)C(C)=C(S3)C)C)OC(C)(C)C
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.65%
CAS	1268524-70-4
Solubility Information	DMSO : ≥ 45 mg/mL (98.47 mM)
Synonym	JQ1
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₃H₂₅ClN₄O₂S
Formula Weight	456.99

Empagliflozin, MedChemExpress

MedChemExpress Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	450.91
Color	Off-White
Physical Form	Solid
Chemical Name or Material	Empagliflozin
Grade	Research
SMILES	ClC(C=CC([C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)=C2)=C2CC(C=C3)=CC=C3O[C@H]4CCOC4
For Use With (Application)	Metabolism-sugar/lipid metabolism
Percent Purity	98.74%
CAS	864070-44-0
Solubility Information	DMSO : 50 mg/mL (110.89 mM; Need ultrasonic) ∣H2O : 0.11 mg/mL (0.24 mM; Need ultrasonic and warming)
Synonym	BI 10773
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₃H₂₇ClO₇
Formula Weight	450.91

ARQ 531, MedChemExpress

MedChemExpress ARQ 531 (MK-1026) is a reversible non-covalent and orally active inhibitor of Bruton’s Tyrosine Kinase (BTK), with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	478.93
Color	Off-White
Physical Form	Powder
Chemical Name or Material	ARQ 531
Grade	Research
SMILES	O=C(C1=C(C=C(OC2=CC=CC=C2)C=C1)Cl)C3=CNC4=NC=NC(N[C@@H]5CC[C@@H](CO)OC5)=C34
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.52%
CAS	2095393-15-8
Solubility Information	DMSO : ≥ 50 mg/mL (104.40 mM)
Health Hazard 1	H302∣H315∣H319∣H335
Synonym	MK-1026
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₂₃ClN₄O₄
Formula Weight	478.93

Rupatadine Fumarate, MedChemExpress

MedChemExpress Rupatadine (UR-12592) Fumarate is a potent, orally active and long-lasting dual PAF/H1 antagonist, with Kis of 0.55 μM and 0.1 μM, respectively. Rupatadine Fumarate can be used for the research of allergic rhinitis and urticaria.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	532.03
Color	White
Physical Form	Solid
Chemical Name or Material	Rupatadine Fumarate
Grade	Research
SMILES	CC1=CN=CC(CN2CC/C(CC2)=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C5\3)=C1.O=C(O)/C=C/C(O)=O
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.15%
CAS	182349-12-8
Solubility Information	DMSO : 30 mg/mL (56.39 mM; Need ultrasonic and warming)
Health Hazard 1	H302
Synonym	UR-12592 Fumarate
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₃₀H₃₀ClN₃O₄
Formula Weight	532.03

BAPTA, MedChemExpress

MedChemExpress BAPTA is a non-permeable, selective extracellular calcium chelator, with 105-fold greater affinity for Ca2+ than Mg2+. BAPTA is a valuable tool to study the role of calcium in cell signaling.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	476.43
Color	Off-White
Physical Form	Solid
Chemical Name or Material	BAPTA
Grade	Research
SMILES	O=C(O)CN(C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(O)=O)CC(O)=O)CC(O)=O
Percent Purity	97.0%
CAS	85233-19-8
Solubility Information	1M NaOH : 100 mg/mL (209.89 mM; ultrasonic and adjust pH to 11 with NaOH) ∣DMSO : 15.62 mg/mL (32.79 mM; ultrasonic and warming and heat to 60°C)
Health Hazard 1	H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₂H₂₄N₂O₁₀
Formula Weight	476.43

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