1,1-Dimethylbiguanide hydrochloride, Thermo Scientific™

Product Code	Brand	Quantity
15485609	Thermo Scientific Alfa Aesar J63361.06	5g
15495609	Thermo Scientific Alfa Aesar J63361.14	25g
15405619	Thermo Scientific Alfa Aesar J63361.22	100g

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• 1,1-Dimethylbiguanide consists of two guanidines with methyl substitutions at position 1

• 1,1-Dimethylbiguanide hydrochloride inhibits complex I of the mitochondrial respiratory chain, increasing AMP and activating target genes

• 1,1-Dimethylbiguanide hydrochloride enhances insulin sensitivity and fatty acid oxidation in cells

• 1,1-Dimethylbiguanide hydrochloride may also have antineoplastic action through the mammalian target of rapamycin pathway

• It is suitable for the laboratory research of diabetes, obesity, and related metabolic disorders

• It is also useful for the laboratory study of mammalian target of rapamycin (mTOR) pathways and AMPK ratios within the cell

Chemical Identifiers

• CAS: 1115-70-4
• Molecular Weight (g/mol): 165.63
• InChI Key: OETHQSJEHLVLGH-UHFFFAOYSA-N
• PubChem CID: 14219
• SMILES: [H+].[Cl-].CN(C)C(=N)N=C(N)N

• Molecular Formula: C4H12ClN5
• MDL Number: MFCD00012582
• Synonym: metformin hydrochloride, 1,1-dimethylbiguanide hydrochloride, metformin hcl, glucophage, riomet, diabefagos, meguan, metformin monohydrochloride, benofomin, denkaform
• IUPAC Name: hydrogen 1-[(diaminomethylidene)amino]-N,N-dimethylmethanimidamide chloride

Specifications

• CAS: 1115-70-4
• Linear Formula: NH₂C(=NH)NHC(=NH)N(CH₃)₂·HCl
• Merck Index: 14,5938
• Solubility Information: Soluble in water (50mg/ml),ethanol,and DMSO (50 mM).
• SMILES: [H+].[Cl-].CN(C)C(=N)N=C(N)N
• Molecular Weight (g/mol): 165.63
• Formula Weight: 165.62

• Molecular Formula: C4H12ClN5
• MDL Number: MFCD00012582
• Synonym: metformin hydrochloride, 1,1-dimethylbiguanide hydrochloride, metformin hcl, glucophage, riomet, diabefagos, meguan, metformin monohydrochloride, benofomin, denkaform
• InChI Key: OETHQSJEHLVLGH-UHFFFAOYSA-N
• IUPAC Name: hydrogen 1-[(diaminomethylidene)amino]-N,N-dimethylmethanimidamide chloride
• PubChem CID: 14219
• Chemical Name or Material: 1,1-Dimethylbiguanide hydrochloride

Safety and Handling

GHS H Statement
H302-H315-H319
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.

P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c

H302-H315-H319-H335

missing translation for 'einecsNumber' : 214-230-6

missing translation for 'rtecsNumber' : DU1800000

missing translation for 'tsca' : No

Recommended Storage : Keep cold

RUO – Research Use Only