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CAS RN 75747-14-7

H3CO(R)(R)H3CNHH2CONHO(R)OCH3(R)ONH2O(R)CH3(S)OHCH3H3CO(Z)(E)(E)

CAS RN 75747-14-7

IUPAC Name: (4Z,6E,8R,9R,10E,12R,13S,14R,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-[(prop-2-en-1-yl)amino]-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Synonyms: tanespimycin
Molecular Weight (g/mol): 585.7
Molecular Formula: C31H43N3O8
InChi Key: AYUNIORJHRXIBJ-CQFHKJEWSA-N
SMILES: CO[C@@H]1C[C@H](C)CC2=C(NCC=C)C(=O)C=C(NC(=O)\C(C)=C/C=C/[C@@H](OC)[C@H](OC(N)=O)\C(C)=C\[C@@H](C)[C@@H]1O)C2=O
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1 – 4 of 4 results
1

17-(Allylamino)-17-demethoxygeldanamycin, 99%

CAS: 75747-14-7 Molecular Formula: C31H43N3O8 Molecular Weight (g/mol): 585.698 MDL Number: MFCD04973892 InChI Key: AYUNIORJHRXIBJ-MKJFUHJFSA-N Synonym: 17-aag PubChem CID: 133688938 IUPAC Name: [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate SMILES: CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC

PubChem CID 133688938
CAS 75747-14-7
Molecular Weight (g/mol) 585.698
MDL Number MFCD04973892
SMILES CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC
Synonym 17-aag
IUPAC Name [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
InChI Key AYUNIORJHRXIBJ-MKJFUHJFSA-N
Molecular Formula C31H43N3O8
2

Tocris Bioscience™ 17-AAG
GREENER_CHOICE

3

Melford 17-AAG

17-AAG (17-Allylamino-17-demethoxygeldanamycin) is a synthetic derivative of geldanamycin. Like geldanamycin, 17-AAG is recognized for its role as an inhibitor of heat shock protein 90 (Hsp90), a molecular chaperone involved in protein folding and stabilization.

CAS 75747-14-7
Molecular Formula C31H43N3O8
4

Tanespimycin, MedChemExpress

MedChemExpress Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90. Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 585.69
Color Pale Purple
Physical Form Powder
Chemical Name or Material Tanespimycin
Grade Research
SMILES O=C(C(NC(/C(C)=C/C=C\[C@H](OC)[C@H](/C(C)=C/[C@@H]([C@H]([C@H](C[C@@H](C1)C)OC)O)C)OC(N)=O)=O)=CC2=O)C1=C2NCC=C
For Use With (Application) Cancer-Kinase/protease
Percent Purity 97.41%
CAS 75747-14-7
Solubility Information DMSO : 50 mg/mL (85.37 mM; Need ultrasonic)
Health Hazard 1 H302∣H315∣H319∣H335
Synonym 17-AAG NSC 330507 CP 127374
Purity Grade Notes Research
Recommended Storage 4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Shelf Life 4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Molecular Formula C31H43N3O8
Formula Weight 585.69