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Tanespimycin, MedChemExpress

Product Code. 16482836
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Product Code. 16482836

Brand: Medchem Express HY10211

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Description

MedChemExpress Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90. Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression.

Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90. Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression.

Specifications

Chemical Name or Material Tanespimycin
Physical Form Powder
CAS 75747-14-7
Color Pale Purple
Quantity 25 mg
Purity Grade Notes Research
Molecular Formula C31H43N3O8
For Use With (Application) Cancer-Kinase/protease
Synonym 17-AAG NSC 330507 CP 127374
Solubility Information DMSO : 50 mg/mL (85.37 mM; Need ultrasonic)
SMILES O=C(C(NC(/C(C)=C/C=C\[C@H](OC)[C@H](/C(C)=C/[C@@H]([C@H]([C@H](C[C@@H](C1)C)OC)O)C)OC(N)=O)=O)=CC2=O)C1=C2NCC=C
Molecular Weight (g/mol) 585.69
Formula Weight 585.69
Percent Purity 97.41%
Grade Research
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Research purposes only

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