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Imidazoles

Aromatic organic heterocyclic compounds that consist of a diazole with non-adjacent nitrogen atoms with the formula: C3N2H4.

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1 – 15 of 44 results
1

S-Gboxin, MedChemExpress

MedChemExpress S-Gboxin, a functional analogue of Gboxin, inhibits growth of mouse and human glioblastoma (GBM) with an IC50 of 470 nM. Antitumour activity.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 600.45
Color White
Physical Form Solid
Chemical Name or Material S-Gboxin
Grade Research
SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(CN2C(C=CC=C3)=C3[N+](C)=C2C4=CC(C(F)(F)F)=CC=C4)=O.[I-]
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.3%
CAS 2101317-21-7
Solubility Information DMSO : 93.33 mg/mL (155.43 mM; Need ultrasonic) ∣H2O : 1 mg/mL (1.67 mM; ultrasonic and warming and heat to 67°C)
Purity Grade Notes Research
Recommended Storage -20°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life -20°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula C27H32F3IN2O2
Formula Weight 600.45
2

Tipifarnib (S enantiomer), MedChemExpress

MedChemExpress Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 489.4
Color White
Physical Form Solid
Chemical Name or Material Tipifarnib (S enantiomer)
Grade Research
SMILES O=C1N(C)C2=C(C=C([C@](C3=CC=C(Cl)C=C3)(N)C4=CN=CN4C)C=C2)C(C5=CC=CC(Cl)=C5)=C1
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.92%
CAS 192185-71-0
Solubility Information DMSO : 25 mg/mL (51.08 mM; Need ultrasonic)
Synonym IND-58359 S enantiomer (S)-(-)-R-115777
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C27H22Cl2N4O
Formula Weight 489.4
3

(S)-Purvalanol B, MedChemExpress

MedChemExpress (S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is a cyclin-dependent kinase inhibitor.

ENCOMPASS_PREFERRED
4

1,1'-Thiocarbonyldiimidazole, tech 90%

CAS: 6160-65-2 Molecular Formula: C7H6N4S Molecular Weight (g/mol): 178.21 MDL Number: MFCD00005289 InChI Key: RAFNCPHFRHZCPS-UHFFFAOYSA-N Synonym: 1,1'-thiocarbonyldiimidazole,thiocarbonyldiimidazole,n,n'-thiocarbonyldiimidazole,di 1h-imidazol-1-yl methanethione,1,1-thiocarbonyldiimidazole,di imidazol-1-yl methanethione,n,n'-thiocarbonyldiimidazole tcdi,1h-imidazole, 1,1'-carbonothioylbis,n,n-thiocarbonyldiimidazole,1,1'-carbonothioylbis-1h-imidazole PubChem CID: 80264 IUPAC Name: di(imidazol-1-yl)methanethione SMILES: S=C(N1C=CN=C1)N1C=CN=C1

PubChem CID 80264
CAS 6160-65-2
Molecular Weight (g/mol) 178.21
MDL Number MFCD00005289
SMILES S=C(N1C=CN=C1)N1C=CN=C1
Synonym 1,1'-thiocarbonyldiimidazole,thiocarbonyldiimidazole,n,n'-thiocarbonyldiimidazole,di 1h-imidazol-1-yl methanethione,1,1-thiocarbonyldiimidazole,di imidazol-1-yl methanethione,n,n'-thiocarbonyldiimidazole tcdi,1h-imidazole, 1,1'-carbonothioylbis,n,n-thiocarbonyldiimidazole,1,1'-carbonothioylbis-1h-imidazole
IUPAC Name di(imidazol-1-yl)methanethione
InChI Key RAFNCPHFRHZCPS-UHFFFAOYSA-N
Molecular Formula C7H6N4S
5

Carbimazole, 98%, Thermo Scientific™

CAS: 22232-54-8 Molecular Formula: C7H10N2O2S Molecular Weight (g/mol): 186.23 InChI Key: CFOYWRHIYXMDOT-UHFFFAOYSA-N Synonym: carbimazole,athyromazole,carbimazol,carbethoxymethimazole,neomercazole,carbinazole,neo-thyreostat,basolest,carbimazolum,thyrostat PubChem CID: 31072 ChEBI: CHEBI:617099 IUPAC Name: ethyl 3-methyl-2-sulfanylideneimidazole-1-carboxylate SMILES: CCOC(=O)N1C=CN(C1=S)C

PubChem CID 31072
CAS 22232-54-8
Molecular Weight (g/mol) 186.23
ChEBI CHEBI:617099
SMILES CCOC(=O)N1C=CN(C1=S)C
Synonym carbimazole,athyromazole,carbimazol,carbethoxymethimazole,neomercazole,carbinazole,neo-thyreostat,basolest,carbimazolum,thyrostat
IUPAC Name ethyl 3-methyl-2-sulfanylideneimidazole-1-carboxylate
InChI Key CFOYWRHIYXMDOT-UHFFFAOYSA-N
Molecular Formula C7H10N2O2S
6

1,1'-Thiocarbonyldiimidazole, 90%, Tech.

CAS: 6160-65-2 Molecular Formula: C7H6N4S Molecular Weight (g/mol): 178.21 MDL Number: MFCD00005289 InChI Key: RAFNCPHFRHZCPS-UHFFFAOYSA-N Synonym: 1,1'-thiocarbonyldiimidazole,thiocarbonyldiimidazole,n,n'-thiocarbonyldiimidazole,di 1h-imidazol-1-yl methanethione,1,1-thiocarbonyldiimidazole,di imidazol-1-yl methanethione,n,n'-thiocarbonyldiimidazole tcdi,1h-imidazole, 1,1'-carbonothioylbis,n,n-thiocarbonyldiimidazole,1,1'-carbonothioylbis-1h-imidazole PubChem CID: 80264 IUPAC Name: di(imidazol-1-yl)methanethione SMILES: S=C(N1C=CN=C1)N1C=CN=C1

PubChem CID 80264
CAS 6160-65-2
Molecular Weight (g/mol) 178.21
MDL Number MFCD00005289
SMILES S=C(N1C=CN=C1)N1C=CN=C1
Synonym 1,1'-thiocarbonyldiimidazole,thiocarbonyldiimidazole,n,n'-thiocarbonyldiimidazole,di 1h-imidazol-1-yl methanethione,1,1-thiocarbonyldiimidazole,di imidazol-1-yl methanethione,n,n'-thiocarbonyldiimidazole tcdi,1h-imidazole, 1,1'-carbonothioylbis,n,n-thiocarbonyldiimidazole,1,1'-carbonothioylbis-1h-imidazole
IUPAC Name di(imidazol-1-yl)methanethione
InChI Key RAFNCPHFRHZCPS-UHFFFAOYSA-N
Molecular Formula C7H6N4S
7

6-​Thioinosine, MedChemExpress

MedChemExpress 6-​Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 284.29
Color Off-White
Physical Form Powder
Chemical Name or Material 6-​Thioinosine
Grade Research
SMILES S=C1NC=NC2=C1N=CN2C3[C@@H]([C@@H]([C@@H](CO)O3)O)O
For Use With (Application) Metabolism-protein/nucleotide metabolism
Percent Purity 97.0%
CAS 574-25-4
Solubility Information DMSO : 83.33 mg/mL (293.12 mM; Need ultrasonic)
Health Hazard 1 H302
Synonym 6TI 6-Mercaptopurine riboside
Purity Grade Notes Research
Recommended Storage -20°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Shelf Life -20°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Molecular Formula C10H12N4O4S
Formula Weight 284.29
8

ADU-S100 ammonium salt, MedChemExpress

MedChemExpress ADU-S100 ammonium salt (MIW815 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 724.6
Color White
Physical Form Solid
Chemical Name or Material ADU-S100 ammonium salt
Grade Research
SMILES OC1([H])[C@](O[P@](S)(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)=O)([H])[C@H](N6C7=NC=NC(N)=C7N=C6)O[C@]1([H])CO[P@]5(S)=O.N.N
For Use With (Application) COVID-19-immunoregulation
Percent Purity 95.87%
CAS 1638750-96-5
Solubility Information DMSO : 15 mg/mL (20.70 mM; Need ultrasonic and warming) ∣H2O : 0.5 mg/mL (0.69 mM; ultrasonic and warming and heat to 60°C)
Synonym MIW815 ammonium saltML RR-S2 CDA ammonium salt
Purity Grade Notes Research
Recommended Storage 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula C20H30N12O10P2S2
Formula Weight 724.6
9

ADU-S100, MedChemExpress

MedChemExpress ADU-S100 (MIW815), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 690.54
Color Off-White
Physical Form Solid
Chemical Name or Material ADU-S100
Grade Research
SMILES O[C@H]1[C@](O[P@](S)(OC[C@](O[C@](N2C3=NC=NC(N)=C3N=C2)([H])[C@@H]4O)([H])[C@@]4([H])O5)=O)([H])[C@@](N6C7=NC=NC(N)=C7N=C6)([H])O[C@]1([H])CO[P@]5(S)=O
For Use With (Application) COVID-19-immunoregulation
Percent Purity 98.01%
CAS 1638241-89-0
Solubility Information H2O : 20 mg/mL (28.96 mM; Need ultrasonic)
Synonym MIW815 ML RR-S2 CDA
Purity Grade Notes Research
Recommended Storage -20°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Shelf Life -20°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Molecular Formula C20H24N10O10P2S2
Formula Weight 690.54
10

Quizartinib, MedChemExpress

MedChemExpress Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 560.67
Color Off-White
Physical Form Solid
Chemical Name or Material Quizartinib
Grade Research
SMILES O=C(NC1=NOC(C(C)(C)C)=C1)NC2=CC=C(C=C2)C3=CN4C(SC5=CC(OCCN6CCOCC6)=CC=C45)=N3
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.87%
CAS 950769-58-1
Solubility Information DMSO : ≥ 33 mg/mL (58.86 mM)
Synonym AC220
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C29H32N6O4S
Formula Weight 560.67
11

PH-064, MedChemExpress

MedChemExpress PH-064 (BIM-46187) is an inhibitor of heterotrimeric G-protein complex.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 795.11
Color Light Yellow
Physical Form Solid
Chemical Name or Material PH-064
Grade Research
SMILES O=C([C@H](CSSC[C@@H](C(N1CCN2C([C@@H]1CC3CCCCC3)=NC(C4=CC=CC=C4)=C2)=O)N)N)N([C@H]5CC6CCCCC6)CCN(C5=N7)C=C7C8=CC=CC=C8
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 96.95%
CAS 892546-37-1
Solubility Information DMSO : 100 mg/mL (125.77 mM; Need ultrasonic)
Synonym BIM-46187
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C44H58N8O2S2
Formula Weight 795.11
12

Pentiapine, MedChemExpress

MedChemExpress Pentiapine (CGS 10746) is a dopamine release inhibitor without binding to synaptic dopamine receptor sites.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 299.39
Color Off-White
Physical Form Solid
Chemical Name or Material Pentiapine
Grade Research
SMILES CN1CCN(C2=NC3=CC=CC=C3SC4=NC=CN42)CC1
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 99.33%
CAS 81382-51-6
Solubility Information DMSO : 100 mg/mL (334.01 mM; Need ultrasonic)
Synonym CGS 10746
Purity Grade Notes Research
Recommended Storage 4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Shelf Life 4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Molecular Formula C15H17N5S
Formula Weight 299.39
13

TC13172, MedChemExpress

MedChemExpress TC13172 is a mixed lineage kinase domain-like protein (MLKL) inhibitor with an EC50 value of 2 nM for HT-29 cells.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 388.4
Color Light Yellow
Physical Form Solid
Chemical Name or Material TC13172
Grade Research
SMILES O=C1C2=C(N=C(S(C)(=O)=O)N2C)N(CC#CC3=CC(O)=CC=C3)C(N1C)=O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.73%
CAS 2093393-05-4
Solubility Information DMSO : 25 mg/mL (64.37 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C17H16N4O5S
Formula Weight 388.4
14

GSK319347A, MedChemExpress

MedChemExpress GSK319347A is a dual inhibitor of TBK1 and IKKε with IC50s of 93 nM and 469 nM, respectively. GSK319347A also inhibits IKK2 with an IC50 of 790 nM.

ENCOMPASS_PREFERRED
15

GlyRS-IN-1, MedChemExpress

MedChemExpress GlyRS-IN-1 is a glycyl-tRNA synthase (GlyRS) inhibitor extracted from patent WO 2017066459 A1. GlyRS-IN-1 can also inhibit the growth of bacteria.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 403.37
Color Off-White
Physical Form Solid
Chemical Name or Material GlyRS-IN-1
Grade Research
SMILES O[C@@H]1[C@@H](COS(=O)(NC(CN)=O)=O)O[C@@H](N2C(N=CN=C3N)=C3N=C2)[C@@H]1O
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.14%
CAS 112921-11-6
Solubility Information DMSO : 100 mg/mL (247.91 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage -20°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Shelf Life -20°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Molecular Formula C12H17N7O7S
Formula Weight 403.37