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Quizartinib, MedChemExpress

Product Code. 16486056
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Product Code. 16486056 Supplier Medchem Express Supplier No. HY13001

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Description

MedChemExpress Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis.

Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis.

Specifications

Chemical Name or Material Quizartinib
CAS 950769-58-1
Color Off-White
Purity Grade Notes Research
Molecular Formula C29H32N6O4S
Quantity 100 mg
Synonym AC220
Solubility Information DMSO : ≥ 33 mg/mL (58.86 mM)
SMILES O=C(NC1=NOC(C(C)(C)C)=C1)NC2=CC=C(C=C2)C3=CN4C(SC5=CC(OCCN6CCOCC6)=CC=C45)=N3
Molecular Weight (g/mol) 560.67
Formula Weight 560.67
Percent Purity 98.87%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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