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Aromatic organic compounds that consist of a five-membered ring with four carbon atoms, one oxygen atom, and two double bonds.

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1 – 4 of 4 results
1

4E2RCat, MedChemExpress

MedChemExpress 4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 455.93
Color Yellow
Physical Form Solid
Chemical Name or Material 4E2RCat
Grade Research
SMILES O=C(O)C1=CC(C2=CC=C(/C=C(SC(N3CC4=CC=CC=C4)=S)/C3=O)O2)=CC=C1Cl
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 98.0%
CAS 432499-63-3
Solubility Information DMSO : 23.33 mg/mL (51.17 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C22H14ClNO4S2
Formula Weight 455.93
2

Leukadherin-1, MedChemExpress

MedChemExpress Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC50 of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 421.49
Color Orange
Physical Form Solid
Chemical Name or Material Leukadherin-1
Grade Research
SMILES O=C(O)C1=CC=C(C2=CC=C(/C=C(SC(N3CC4=CC=CC=C4)=S)/C3=O)O2)C=C1
For Use With (Application) COVID-19-immunoregulation
Percent Purity 98.0%
CAS 344897-95-6
Solubility Information DMSO : 5 mg/mL (11.86 mM; Need ultrasonic)
Health Hazard 1 H302∣H410
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C22H15NO4S2
Formula Weight 421.49
3

Oglemilast, MedChemExpress

MedChemExpress Oglemilast (GRC 3886) is a potent and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 0.5 nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast has the potential for inflammatory airway diseases.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 516.3
Color Khaki
Physical Form Solid
Chemical Name or Material Oglemilast
Grade Research
SMILES O=C(C1=C2C(OC3=CC=C(NS(=O)(C)=O)C=C23)=C(OC(F)F)C=C1)NC4=C(Cl)C=NC=C4Cl
For Use With (Application) COVID-19-immunoregulation
Percent Purity 98.2%
CAS 778576-62-8
Solubility Information DMSO : 4 mg/mL (7.75 mM; Need ultrasonic)
Synonym GRC 3886
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C20H13Cl2F2N3O5S
Formula Weight 516.3
4

KYA1797K, MedChemExpress

MedChemExpress KYA1797K is a potent and selective Wnt/β-catenin inhibitor with an IC50 of 0.75 μM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 442.51
Color Orange
Physical Form Solid
Chemical Name or Material KYA1797K
Grade Research
SMILES O=C(O[K])CCN(C/1=O)C(SC1=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)=S
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.0%
CAS 1956356-56-1
Solubility Information DMSO : 6 mg/mL (13.56 mM; Need ultrasonic) ∣H2O : 1 mg/mL (2.26 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula C17H11KN2O6S2
Formula Weight 442.51