SIX5 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16862135	Proteintech 22938-1-AP-20UL	20 μL
16852135	Proteintech 22938-1-AP-150UL	150 μL

Description

Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor that is expressed in various structures of the adult eye. Localized to the cytoplasm in early development and to the nucleus in the later stages of development,Six5 is involved in regulation of organogenesis and in maintece of retinal formation. Six5 is able to bind the 5′-TCA[AG][AG]TTNC-3′ DNA sequence found in the myogenin and IGFBP5 promoters and, through this binding, can control transcription of the associated mRNA. Six5 is regulated via association with DACH1 (dachshund homolog 1) and is co-activated by the EYA (eyes absent) proteins. Defects in the gene encoding Six5 are the cause of branchiooto- renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, a deep overbite and myopia. Two isoforms exist due to alternative splicing events.

Specifications

• Antigen: SIX5
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q8N196
• Gene ID (Entrez): 147912
• Immunogen: SIX5 Fusion Protein Ag18993
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: SIX5

• Concentration: 0.47 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: BOR2, DMAHP, Homeobox protein SIX5, Sine oculis homeobox homolog 5, SIX homeobox 5, SIX5
• Gene Symbols: SIX5
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody