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SIX5 Rabbit anti-Human, Polyclonal, Proteintech

Product Code. 16862135 Shop All Proteintech Products
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20 μL
150 μL
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20µL
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16862135 20 μL 20µL
16852135 150 μL 150µL
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Product Code. 16862135 Supplier Proteintech Supplier No. 229381AP20UL

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Rabbit Polyclonal Antibody

Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor that is expressed in various structures of the adult eye. Localized to the cytoplasm in early development and to the nucleus in the later stages of development,Six5 is involved in regulation of organogenesis and in maintece of retinal formation. Six5 is able to bind the 5′-TCA[AG][AG]TTNC-3′ DNA sequence found in the myogenin and IGFBP5 promoters and, through this binding, can control transcription of the associated mRNA. Six5 is regulated via association with DACH1 (dachshund homolog 1) and is co-activated by the EYA (eyes absent) proteins. Defects in the gene encoding Six5 are the cause of branchiooto- renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, a deep overbite and myopia. Two isoforms exist due to alternative splicing events.

Specifications

Antigen SIX5
Applications Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation
Classification Polyclonal
Concentration 0.47 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SIX5
Gene Accession No. Q8N196
Gene Alias BOR2, DMAHP, Homeobox protein SIX5, Sine oculis homeobox homolog 5, SIX homeobox 5, SIX5
Gene Symbols SIX5
Host Species Rabbit
Immunogen SIX5 Fusion Protein Ag18993
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 147912
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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