Thermo Scientific™ Pierce™ Sulfo-NHS Crosslinker

Prepare amine-reactive sulfo-NHS-ester crosslinkers or enhance carbodiimide (EDC) conjugation for peptides or proteins using N-hydroxysulfosuccinimide, CAS 106627-54-7.

Brand: Thermo Scientific™

Manufacturer Part Number: 24510

UNSPSC: 12161502

Code: PN

Additional Details:
Additional Details: CAS Number: 63038-44-8 Weight: 1.81440kg

Product Code. 10391314

Quantity Price
1 £ 221.0 / 500mg
EU Stock 97
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Description and Specification


Spacer Arm Length
Formulation N-Hydroxysulfosuccinimide; powder solid
Storage Requirements Store as detailed on product information sheet.
Molecular Weight 217.13
Sufficient For 461mL of typical 1X (5mM) reaction solution, or approx. 250 uses at 2mg reagent per use
Membrane Permeable Yes
Description Pierce Sulfo-NHS
PEGylated No
Chemical Reactivity Carboxyl-to-Amine
Water Soluble Yes
Quantity 500mg


  • Forms an acyl amino ester with carboxyl groups when used with the EDC
  • Sulfo-NHS-activated molecule reacts efficiently with primary amines, resulting in stable amide bond
  • Allows for two-step EDC reactions between carboxyl- and amine-containing molecules
  • Sulfo-NHS-activated molecule can be stabilized by drying, allowing manufacture of amine-reactive probes and surfaces
  • Reactive groups: Sulfo-NHS
  • Reactive toward: amino groups (upon activation of carboxylates)