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Thermo Scientific™ SPDP (succinimidyl 3-(2-pyridyldithio)propionate)
Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups on 3-atom spacer arm; forms cleavable disulfide bonds with cysteines.
Brand: Thermo Scientific™ 21857
146.67 GBP valid until 2024-03-29
Use promo code "21615" to get your promotional price.
Code : PN
Additional Details : CAS Number : 141-78-6 Weight : 1.81440kg
Description
Thermo Scientific™ Pierce SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.
Highlights:
- Widely used in immunochemistry; conjugates used in drug carrier systems, antibody production and enzyme immunoassays
- Can be used as a protein thiolation reagent
- Reactive groups: NHS ester and pyridyldisulfide
- Reactive toward: amino and sulfhydryl groups
Specifications
Amine-Sulfhydryl | |
SPDP | |
No | |
Upon receipt store at -20°C protected from moisture. | |
Ambient | |
Chemical Labeling | |
NHS Ester, Pyridyldisulfide | |
Powder | |
DMF, DMSO | |
No |
By Thiols | |
312.36 | |
6.8 Å | |
Yes | |
Pierce™ | |
Heterobifunctional | |
Short (<10 Å) | |
50 mg | |
Standard, Premium-grade | |
Crosslinker |
Safety and Handling
- SPDP (succinimidyl 3-(2-pyridyldithio)propionate)
Signal Word
- Warning
Hazard Category
- Serious eye damage/eye irritation Category 2
- Skin corrosion/irritation Category 2
- Specific target organ toxicity Category 3
Hazard Statement
- H315-Causes skin irritation.
- H319-Causes serious eye irritation.
- H335-May cause respiratory irritation.
Precautionary Statement
- P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
- P264-Wash hands thoroughly after handling.
- P271-Use only outdoors or in a well-ventilated area.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P312-Call a POISON CENTER/doctor/if you feel unwell.
- P332+P313-If skin irritation occurs: Get medical advice/attention.
- P337+P313-If eye irritation persists: Get medical advice/attention.
- P362+P364-Take off contaminated clothing and wash it before reuse.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
Supplemental information
- MIXTURE LIST-Contains : 1-[1-Oxo-3-(2-pyridyldithio)pro poxy]pyrrolidine-2,5-dione
For Research Use Only. Not for use in diagnostic procedures.