Thermo Scientific™ SMPH (Succinimidyl 6-((beta-maleimidopropionamido)hexanoate))

Description

Crosslink amines to sulfhydryls with this long crosslinker composed of NHS-ester and maleimide groups at ends of an aliphatic, 12-atom (14.2A) spacer arm.

Thermo Scientific™ Pierce SMPH is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a long spacer arm (14.2 Ås).

Highlights:

• NHS-ester reacts with a primary amine to form a stable amide bond
• Maleimide reacts with a sulfhydryl forming a stable thioether bond
• More hydrophilic spacer than BMPS, GMBS, EMCS or SMPB
• Reactive groups: NHS ester and maleimide
• Reactive toward: amino and sulfhydryl groups

Specifications

• Chemical Reactivity: Amine-Sulfhydryl
• Cleavable: No
• Description: SMPH
• Molecular Weight (g/mol): 379.36
• PEGylated: No
• Spacer Arm Length: 14.2 Å
• Content And Storage: Upon receipt store desiccated at 4°C.
• Cell Permeability: Yes
• Shipping Condition: Ambient
• Product Line: Pierce™
• Labeling Method: Chemical Labeling
• Crosslinker Type: Heterobifunctional
• Reactive Moiety: Maleimide, NHS Ester
• Spacer: Medium (10 to 30 Å)
• Form: Solid
• Quantity: 50 mg
• Solubility: DMF, DMSO
• Format: Standard
• Water Soluble: No
• Product Type: Crosslinker

Safety and Handling

Product Identifier

• SMPH (Succinimidyl 6-((beta-maleimidopropionamido)hexanoate))

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P264-Wash hands thoroughly after handling.
• P271-Use only outdoors or in a well-ventilated area.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.
• P403+P233-Store in a well-ventilated place. Keep container tightly closed.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : SMPH: Succinimidyl-6- (Beta-Maleimidopropionamido) Hexanoate

For Research Use Only. Not for use in diagnostic procedures.