Thermo Scientific™ Pierce™ DSS Crosslinker

Crosslink amines to amines with disuccinimidyl suberate composed of NHS-ester groups with a membrane-permeable, mid-length spacer for intracellular protein crosslinking.

Brand: Thermo Scientific™

Manufacturer Part Number: 21555


UNSPSC: 12161502

Code: PN

Additional Details:
Additional Details: Weight: 0.00100kg

Product Code. 10540434

Quantity Price
1 £141.00 / 1g
EU Stock 4
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Description and Specification


Chemical Reactivity Amine-to-Amine
Cleavable No
Description Pierce DSS
Formulation Disuccinimidyl suberate; powder solid
Membrane Permeable Yes
Molecular Weight 368.34
PEGylated No
Quantity 1g
Sufficient For 2715mL of typical 1X (1mM) reaction solution, or approx. 500 uses at 2mg reagent per use
Spacer Arm Length 11.4Å
Water Soluble No


  • Chemical crosslinking of intracellular proteins prior to cell lysis and immunoprecipitation
  • “Fix” protein interactions to allow identification of weak or transient protein interactions
  • Protein crosslinking to create bioconjugates via single-step reactions
  • Crosslink oriented antibodies to Protein A or G agarose
  • Immobilize proteins onto amine-coated surfaces


Technical documents