Thermo Scientific™ Pierce™ DSS Crosslinker

Crosslink amines to amines with disuccinimidyl suberate composed of NHS-ester groups with a membrane-permeable, mid-length spacer for intracellular protein crosslinking.

Brand: Thermo Scientific™

Manufacturer Part Number: 21655

UNSPSC: 12161502

Code: PN

Additional Details:
Additional Details: Weight: 0.01000kg

Product Code. 10138353

Quantity Price
1 £ 55.5 / 50mg
EU Stock 4
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Description and Specification


Spacer Arm Length 11.4Å
Formulation Disuccinimidyl suberate; powder solid
Cleavable No
Molecular Weight 368.34
Sufficient For 136mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
Description Pierce DSS
Membrane Permeable Yes
Chemical Reactivity Amine-to-Amine
PEGylated No
Water Soluble No
Quantity 50mg


  • Chemical crosslinking of intracellular proteins prior to cell lysis and immunoprecipitation
  • “Fix” protein interactions to allow identification of weak or transient protein interactions
  • Protein crosslinking to create bioconjugates via single-step reactions
  • Crosslink oriented antibodies to Protein A or G agarose
  • Immobilize proteins onto amine-coated surfaces


Technical documents