Thermo Scientific™ Pierce™ BS3 (Sulfo-DSS) Crosslinker

Crosslink amines to amines with BS3; composed of sulfo-NHS-ester groups separated by an 11.4A, water-soluble spacer arm that is useful for cell-surface protein crosslinking.

Brand: Thermo Scientific™

Manufacturer Part Number: 21580

50 MG BS3

UNSPSC: 12161502

Code: PN

Additional Details:
Additional Details: Weight: 0.01000kg

Product Code. 10249963

Quantity Price
1 £123.00 / 50mg
EU Stock 41
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Description and Specification


Chemical Reactivity Amine-to-Amine
Cleavable No
Description Pierce BS3 (Sulfo-DSS)
Formulation Bis(sulfosuccinimidyl) suberate; powder solid
Membrane Permeable No
Molecular Weight 572.43
PEGylated No
Quantity 50mg
Sufficient For 87mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
Spacer Arm Length 11.4Å
Water Soluble Yes


  • Crosslink cell-surface proteins before cell lysis and immunoprecipitation
  • Identify receptor-ligand interactions by chemical crosslinking
  • “Fix” protein interactions to allow identification of weak or transient protein interactions
  • Identify near-neighbor protein interactions
  • Protein crosslinking to create bioconjugates via single-step reactions
  • Immobilize proteins onto amine-coated surfaces


Technical documents