Thermo Scientific™ Pierce™ BS3 (Sulfo-DSS) Crosslinker

Crosslink amines to amines with BS3; composed of sulfo-NHS-ester groups separated by an 11.4A, water-soluble spacer arm that is useful for cell-surface protein crosslinking.

Brand: Thermo Scientific™

Manufacturer Part Number: 21586

UNSPSC: 12161502

Code: PN

Additional Details:
Additional Details: Weight: 0.00100kg

Product Code. 10075843

Quantity Price
1 £ 1026.0 / 1g
EU Stock 1
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Description and Specification


Formulation Bis(sulfosuccinimidyl) suberate; powder solid
Cleavable No
Sufficient For 1747mL of typical 1X (1mM) reaction solution, or approx. 500 uses at 2mg reagent per use
Molecular Weight 572.43
Spacer Arm Length 11.4Å
Membrane Permeable No
Description Pierce BS3
PEGylated No
Chemical Reactivity Amine-to-Amine
Water Soluble Yes
Quantity 1g


  • Crosslink cell-surface proteins before cell lysis and immunoprecipitation
  • Identify receptor-ligand interactions by chemical crosslinking
  • “Fix” protein interactions to allow identification of weak or transient protein interactions
  • Identify near-neighbor protein interactions
  • Protein crosslinking to create bioconjugates via single-step reactions
  • Immobilize proteins onto amine-coated surfaces


Technical documents