Invitrogen™ Gtf2h5 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
17743334	Invitrogen™ PA5121936	20 μL
17733334	Invitrogen™ PA5121935	100 μL

Description

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.

Specifications

• Antigen: Gtf2h5
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q6ZYL4
• Gene ID (Entrez): 404672
• Immunogen: Met1-Lys71 (Accession Q6ZYL4), with N-terminal His Tag.
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Gene: GTF2H5

• Concentration: 0.5 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Alias: 2700017P07Rik; 2810432H05Rik; bA120J8.2; C6orf175; D17Wsu155e; General transcription factor IIH polypeptide 5; General transcription factor IIH subunit 5; general transcription factor IIH, polypeptide 5; GTF2H5; RGD1560991; si:dkey-12h9.4; TFB5; TFB5 ortholog; TFIIH; TFIIH basal transcription factor complex TTDA subunit; TFIIH basal transcription factor complex TTD-A subunit; TGF2H5; TTD; TTD3; TTDA; TTD-A; Unknown (protein for MGC:134263); Unknown (protein for MGC:153434); zgc:153434
• Gene Symbols: GTF2H5
• Isotype: IgG
• Purification Method: Antigen affinity chromatography, Protein A
• Product Type: Antibody