Invitrogen™ Gtf2h5 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5121935

Product Code. 17733334

Description

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.

Specifications

• Antigen: Gtf2h5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GTF2H5
• Gene Alias: 2700017P07Rik; 2810432H05Rik; bA120J8.2; C6orf175; D17Wsu155e; General transcription factor IIH polypeptide 5; General transcription factor IIH subunit 5; general transcription factor IIH, polypeptide 5; GTF2H5; RGD1560991; si:dkey-12h9.4; TFB5; TFB5 ortholog; TFIIH; TFIIH basal transcription factor complex TTDA subunit; TFIIH basal transcription factor complex TTD-A subunit; TGF2H5; TTD; TTD3; TTDA; TTD-A; Unknown (protein for MGC:134263); Unknown (protein for MGC:153434); zgc:153434
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 404672
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: Q6ZYL4
• Gene Symbols: GTF2H5
• Immunogen: Met1-Lys71 (Accession Q6ZYL4), with N-terminal His Tag.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG