Clotrimazole, Thermo Scientific™

Product Code	Brand	Quantity
15486049	Thermo Scientific Alfa Aesar J63895.06	5g
15496049	Thermo Scientific Alfa Aesar J63895.14	25g

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
Clotrimazole is an imidazole derivative and an antifungal compound and a CYP (cytochrome P450) inhibitor. Clotrimazole has been shown to block the intermediate-conductance, IK1 channels (Ca2+ activated K+ channels), in cells such as erythrocytes. In vitro studies of various yeast strains have demonstrated susceptibility to clotrimazole. Clotrimazole is an activator of MB67 and an inhibitor of CYP3A4 and CYP51A1.

Solubility
Soluble in chloroform, DMSO, DMF and alcohols

Notes
Store at room temperature. Incompatible with oxidizing agents.

Chemical Identifiers

• CAS: 23593-75-1
• Molecular Weight (g/mol): 344.842
• InChI Key: VNFPBHJOKIVQEB-UHFFFAOYSA-N
• PubChem CID: 2812
• IUPAC Name: 1-[(2-chlorophenyl)-diphenylmethyl]imidazole

• Molecular Formula: C22H17ClN2
• MDL Number: MFCD00057220
• Synonym: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole
• ChEBI: CHEBI:3764
• SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4

Specifications

• CAS: 23593-75-1
• Molecular Formula: C22H17ClN2
• Merck Index: 14,2417
• Solubility Information: Soluble in chloroform, DMSO, DMF and alcohols
• SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
• Molecular Weight (g/mol): 344.842
• ChEBI: CHEBI:3764
• Chemical Name or Material: Clotrimazole

• Color: White
• MDL Number: MFCD00057220
• Synonym: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole
• InChI Key: VNFPBHJOKIVQEB-UHFFFAOYSA-N
• IUPAC Name: 1-[(2-chlorophenyl)-diphenylmethyl]imidazole
• PubChem CID: 2812
• Formula Weight: 344.84

Safety and Handling

GHS H Statement
H302-H315-H319
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.

P264b-P270-P280-P301+P312-P302+P352-P305+P351+P338-P330-P332+P313-P362-P501c

H302-H315-H319

missing translation for 'einecsNumber' : 245-764-8

missing translation for 'rtecsNumber' : NI4377000

missing translation for 'tsca' : No

Recommended Storage : Ambient temperatures

Product Identifier

• Clotrimazole

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• LONG-TERM AQUATIC HAZARD Chronic 1
• ACUTE AQUATIC Acute 1
• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2

Hazard Statement

• H302-Harmful if swallowed.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H400-Very toxic to aquatic life.
• H410-Very toxic to aquatic life with long lasting effects.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contains : Clotrimazole

RUO – Research Use Only