Clotrimazole, Thermo Scientific™

Specific inhibitor of calcium-activated potassium channels

Brand:  Thermo Scientific Alfa Aesar J63895.14

Product Code. 15496049

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
Clotrimazole is an imidazole derivative and an antifungal compound and a CYP (cytochrome P450) inhibitor. Clotrimazole has been shown to block the intermediate-conductance, IK1 channels (Ca2+ activated K+ channels), in cells such as erythrocytes. In vitro studies of various yeast strains have demonstrated susceptibility to clotrimazole. Clotrimazole is an activator of MB67 and an inhibitor of CYP3A4 and CYP51A1.

Solubility
Soluble in chloroform, DMSO, DMF and alcohols

Notes
Store at room temperature. Incompatible with oxidizing agents.

Chemical Identifiers

• CAS: 23593-75-1
• Molecular Weight (g/mol): 344.842
• InChI Key: VNFPBHJOKIVQEB-UHFFFAOYSA-N
• PubChem CID: 2812
• IUPAC Name: 1-[(2-chlorophenyl)-diphenylmethyl]imidazole

• Molecular Formula: C22H17ClN2
• MDL Number: MFCD00057220
• Synonym: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole
• ChEBI: CHEBI:3764
• SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4

Specifications

• CAS: 23593-75-1
• Quantity: 25g
• MDL Number: MFCD00057220
• Synonym: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole
• InChI Key: VNFPBHJOKIVQEB-UHFFFAOYSA-N
• IUPAC Name: 1-[(2-chlorophenyl)-diphenylmethyl]imidazole
• PubChem CID: 2812
• Formula Weight: 344.84

• Color: White
• Molecular Formula: C22H17ClN2
• Merck Index: 14,2417
• Solubility Information: Soluble in chloroform, DMSO, DMF and alcohols
• SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
• Molecular Weight (g/mol): 344.842
• ChEBI: CHEBI:3764
• Chemical Name or Material: Clotrimazole