beta-Estradiol, 99% (dry wt.), ca 3% water, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11366656	Thermo Scientific Alfa Aesar L03801.03	1 g
11376656	Thermo Scientific Alfa Aesar L03801.06	5 g
11386656	Thermo Scientific Alfa Aesar L03801.14	25 g

Description

β-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner's syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
β-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner′s syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.

Solubility
Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.

Notes
Incompatible with strong oxidizing agents.

Chemical Identifiers

• CAS: 50-28-2
• Molecular Weight (g/mol): 272.388
• InChI Key: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• PubChem CID: 5757
• IUPAC Name: (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

• Molecular Formula: C18H24O2
• MDL Number: MFCD00003693
• Synonym: estradiol, beta-estradiol, 17beta-estradiol, oestradiol, dihydrofolliculin, estrace, ovocyclin, progynon, dihydrotheelin, dihydroxyestrin
• ChEBI: CHEBI:16469
• SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

Specifications

• CAS: 50-28-2
• Molecular Formula: C18H24O2
• Beilstein: 1914275
• Synonym: estradiol, beta-estradiol, 17beta-estradiol, oestradiol, dihydrofolliculin, estrace, ovocyclin, progynon, dihydrotheelin, dihydroxyestrin
• InChI Key: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
• Molecular Weight (g/mol): 272.388
• ChEBI: CHEBI:16469
• Percent Purity: 99%
• Chemical Name or Material: beta-Estradiol

• Melting Point: 175°C to 178°C
• MDL Number: MFCD00003693
• Merck Index: 14,3703
• Solubility Information: Soluble in dimethyl sulfoxide,ethanol ,water,phosphate buffer saline,dimethyl formamide,acetone,dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
• Optical Rotation: +79° (c=1 in Dioxane)
• IUPAC Name: (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
• PubChem CID: 5757
• Formula Weight: 272.39
• Assay: (dry wt.), ≈3% water

Safety and Handling

GHS H Statement
H350-H360
May cause cancer.
May damage fertility or the unborn child.

P201-P202-P260-P263-P264b-P270-P271-P281-P304+P340-P308+P313-P501c

H350-H361fd-H362-H373

missing translation for 'einecsNumber' : 200-023-8

missing translation for 'rtecsNumber' : KG2975000

missing translation for 'tsca' : No

Recommended Storage : Ambient temperatures

RUO – Research Use Only