beta-Estradiol, 99% (dry wt.), ca 3% water

Product Code. 11366656

Brand: Thermo Scientific Alfa Aesar L03801.03

Description

CAS: 50-28-2 | C18H24O2 | 272.388 g/mol

β-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner's syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
β-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner′s syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.

Solubility
Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.

Notes
Incompatible with strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 50-28-2
• Molecular Formula: C18H24O2
• Molecular Weight (g/mol): 272.388
• MDL Number: MFCD00003693
• InChI Key: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• Synonym: estradiol, beta-estradiol, 17beta-estradiol, oestradiol, dihydrofolliculin, estrace, ovocyclin, progynon, dihydrotheelin, dihydroxyestrin
• PubChem CID: 5757
• ChEBI: CHEBI:16469
• IUPAC Name: (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
• SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

• Melting Point: 175°C to 178°C
• Quantity: 1 g
• Beilstein: 1914275
• Merck Index: 14,3703
• Solubility Information: Soluble in dimethyl sulfoxide,ethanol ,water,phosphate buffer saline,dimethyl formamide,acetone,dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
• Optical Rotation: +79° (c=1 in Dioxane)
• Formula Weight: 272.39
• Percent Purity: 99%
• Assay: (dry wt.), ≈3% water
• Chemical Name or Material: beta-Estradiol

Sicherheit und Handhabung

Produktidentifikator

• beta-Estradiol

Signalwort

• Danger

Gefahrenkategorie

• Carcinogenicity Category 1A
• Reproductive toxicity on or via lactation
• Reproductive toxicity Category 2
• Specific target organ toxicity after repeated exposure Category 2

Gefahrenhinweis

• H350-May cause cancer.
• H361fd-Suspected of damaging fertility. Suspected of damaging the unborn child.
• H362-May cause harm to breast-fed children.
• H373-May cause damage to organs.

Sicherheitshinweis

• P201-Obtain special instructions before use.
• P202-Do not handle until all safety precautions have been read and understood.
• P260-Do not breathe dust/fume/gas/mist/vapours/spray.
• P263-Avoid contact during pregnancy/while nursing.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P308+P313-IF exposed or concerned: Get medical advice/attention.

Ergänzende Informationen

• MIXTURE LIST-Contains : Estradiol-17b

Sicherheitsdatenblatt (SDS)

RUO – Research Use Only