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CAS RN 443913-73-3

H3COHNBrFNNONH3C

CAS RN 443913-73-3

IUPAC Name: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Synonyms: vandetanib zactima C22H24BrFN4O2 vande-tanib
Molecular Weight (g/mol): 475.36
Molecular Formula: C22H24BrFN4O2
InChi Key: UHTHHESEBZOYNR-UHFFFAOYSA-N
SMILES: COC1=C(OCC2CCN(C)CC2)C=C2N=CN=C(NC3=CC=C(Br)C=C3F)C2=C1
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Thermo Scientific Chemicals Vandetanib

CAS: 443913-73-3 Molecular Formula: C22H24BrFN4O2 Molecular Weight (g/mol): 475.36 InChI Key: UHTHHESEBZOYNR-UHFFFAOYSA-N IUPAC Name: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine SMILES: COC1=C(OCC2CCN(C)CC2)C=C2N=CN=C(NC3=CC=C(Br)C=C3F)C2=C1

CAS 443913-73-3
Molecular Weight (g/mol) 475.36
SMILES COC1=C(OCC2CCN(C)CC2)C=C2N=CN=C(NC3=CC=C(Br)C=C3F)C2=C1
IUPAC Name N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
InChI Key UHTHHESEBZOYNR-UHFFFAOYSA-N
Molecular Formula C22H24BrFN4O2
2

Vandetanib, TRC

CAS: 443913-73-3 Chemical Name or Material: Vandetanib Formula Weight: 474.1067 InChI Formula: InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) IUPAC Name: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine Molecular Formula: C22 H24 Br F N4 O2 Molecular Weight (g/mol): 475.35 Recommended Storage: -20°C SMILES: COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC4CCN(C)CC4 Synonym: 4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-,N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine,4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline,CH 331,Caprelsa,N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(N-methylpiperidin-4-ylmethoxy)quinazolin-4-amine,N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine,Vandetanib,ZD 6474,Zactima

CAS 443913-73-3
Molecular Weight (g/mol) 475.35
InChI Formula InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
Chemical Name or Material Vandetanib
Synonym 4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-,N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine,4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline,CH 331,Caprelsa,N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(N-methylpiperidin-4-ylmethoxy)quinazolin-4-amine,N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine,Vandetanib,ZD 6474,Zactima
SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC4CCN(C)CC4
Recommended Storage -20°C
Molecular Formula C22 H24 Br F N4 O2
IUPAC Name N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Formula Weight 474.1067
3

Tocris Bioscience™ Vandetanib
GREENER_CHOICE

Potent VEGFR-2 inhibitor, also inhibits EGFR and RET oncoproteins activity

Target VEGF Receptor Inhibitors
CAS 443913-73-3
Purity 0.98
Chemical Name or Material N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
Recommended Storage Store at -20°C
Molecular Formula C22H24BrFN4O2
4

STEMCELL Technologies Vandetanib

Tyrosine kinase inhibitor; Inhibits VEGFR1, KDR, FLT-4, EGFR, FGFR, ABL, RET, and SRC

ENCOMPASS_PREFERRED
CAS 443913-73-3
Purity ≥98%
Molecular Formula C22H24BrFN4O2
5

Vandetanib, MedChemExpress

MedChemExpress Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM).

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 475.35
Color White
Physical Form Powder
Chemical Name or Material Vandetanib
Grade Research
SMILES FC1=CC(Br)=CC=C1NC2=NC=NC3=CC(OCC4CCN(CC4)C)=C(C=C23)OC
For Use With (Application) Cancer-Kinase/protease
Percent Purity 95.0%
CAS 443913-73-3
Solubility Information DMSO : 27.5 mg/mL (57.85 mM; Need ultrasonic and warming)
Health Hazard 1 H302∣H315∣H319∣H335
Synonym ZD6474
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C22H24BrFN4O2
Formula Weight 475.35