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Crosslinking, Labeling and Protein Modification

A variety of reagents used to modify proteins for identification, analysis, research, and other applications.
Protein Labeling Reagents (905)
Protein and Antibody Labeling Kits (290)
Protein Modification Reagents (272)
Crosslinking Reagents (135)
Tandem Mass Tag Reagents (53)

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1
Promotions Available

Invitrogen™ Alexa Fluor™ 647 NHS Ester (Succinimidyl Ester)

Alexa Fluor™ 647 is a bright and photostable far-red dye with excitation ideally suited to the 633 nm laser line.

Emission 672 nm
Excitation 651 nm
2
Promotions Available

Thermo Scientific™ Sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate), No-Weigh™ Format

Crosslink amines to sulfhydryls with this mid-length, water-soluble crosslinker made of NHS-ester and maleimide groups at ends of a cyclohexane-containing, 8-atom spacer arm.

EDGE
Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at -20°C.
Description Sulfo-SMCC
Cleavable No
Water Soluble Yes
Molecular Weight (g/mol) 436.37
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability No
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Maleimide, Sulfo-NHS Ester
Spacer Arm Length 8.3 Å
PEGylated No
3

Invitrogen™ DTT, 1M

DTT, 1M

EDGE
4
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Invitrogen™ Alexa Fluor™ 488 NHS Ester (Succinimidyl Ester)

Alexa Fluor™ 488 is a bright, green-fluorescent dye with excitation ideally suited for the 488 nm laser line.

EDGE
Shipping Condition Room Temperature
Content And Storage Store in freezer (-5 to -30°C) and protect from light.
Product Type Dye
Label or Dye Alexa Fluor™ 488
Emission 517 nm
Excitation 494 nm
Label Type Alexa Fluor
Chemical Reactivity Amine
Product Line Alexa Fluor
5
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Thermo Scientific™ EZ-Link™ Sulfo NHS-LC-LC-Biotin, No-Weigh™ Format

EDGE
Label Type Biotin & Analogs
6
Promotions Available

Thermo Scientific™ Pierce™ Premium Grade DSP (dithiobis(succinimidyl propionate))

Optimize applications where product integrity and risk minimization are paramount with our highest quality formulation of this popular amine-reactive, cleavable crosslinker.

EDGE
Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at 4°C.
Cleavable By Thiols
Water Soluble No
Form Powder
Molecular Weight (g/mol) 404.42
Solubility DMF, DMSO
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability Yes
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Formulation Dithiobis(succinimidylpropionate); powder solid
Reactive Moiety NHS Ester
Spacer Arm Length 12.0 Å
Product Line Pierce
PEGylated No
7
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Thermo Scientific™ EZ-Link™ Sulfo-NHS-LC-Biotin

Thermo Scientific™ EZ-Link™ Sulfo-NHS-LC-Biotin is an intermediate-length, water-soluble biotinylation reagent for labeling antibodies, proteins and other molecules that have primary amines.

EDGE
Cell Permeability Cell-Impermeant
Product Type Sulfo-NHS-LC-Biotin
Spacer Mid-length
Label or Dye Biotin
Solubility DMF (Dimethylformamide),DMSO (Dimethylsulfoxide),Water
Chemical Reactivity Amine
Product Line EZ-Link
8
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Thermo Scientific™ Pierce™ DSG, No-Weigh™ Format

EDGE
Cleavable No
Water Soluble No
Form Powder
Molecular Weight (g/mol) 326.26
Solubility DMF, DMSO
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability Yes
Format Standard, Single-use
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety NHS Ester
Spacer Arm Length 7.7 Å
PEGylated No
9
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Thermo Scientific™ EZ-Link™ Sulfo-NHS-SS-Biotin, No Weigh Format

Thermo Scientific™ EZ-Link™ Sulfo-NHS-SS-Biotin No-Weigh™ Format is a water-soluble, NHS-ester biotinylation reagent whose spacer arm includes a cleavable disulfide bond for reversible labeling of proteins and cell surface primary amines.

EDGE
Chemical Reactivity Amine
10

Molecular Probes™ Alexa Fluor™ 647 Azide, Triethylammonium Salt

The far red-fluorescent Alexa Fluor™ 647 azide is reactive with terminal alkynes via a copper-catalyzed click reaction.

EDGE
11
Promotions Available

Thermo Scientific™ Pierce™ SATA (N-succinimidyl S-acetylthioacetate)

Short (2.8A), amine-reactive (NHS ester) sulfhydryl-addition reagent; creates stable (protected yet exposable) -SH group for protein crosslinking strategies.

EDGE
12
Promotions Available

Thermo Scientific™ Pierce™ Cysteine-HCl

Make sulfhydryl assay standards or perform protein refolding experiments using this pure, crystalline cysteine hydrochloride (Cys-HCl).

EDGE
13

Thermo Scientific™ EGS (ethylene glycol bis(succinimidyl succinate))

Crosslink amines to amines with this membrane permeable crosslinker composed of NHS-ester groups and a 16.1A hydroxylamine-cleavable spacer arm.

EDGE
14
Promotions Available

Invitrogen™ Alexa Fluor™ 647 C2 Maleimide

Alexa Fluor™ 647 is a bright, far-red fluorescent dye with excitation ideally suited for the 594 nm or 633 nm laser lines.

EDGE
15

Invitrogen™ Click-iT™ Plus OPP Alexa Fluor™ 647 Protein Synthesis Assay Kit
GREENER_CHOICE

Provides non-radioactive method for detection of protein synthesis using fluorescence microscopy or high-content imaging

EDGE