Phenoxy compounds
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Diphenylcarbazone-mercuric Reagent (I+II) EU Pharmacopoeia, Fisher Chemical™
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I-CBP112, MedChemExpress
MedChemExpress I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor, that inhibits the CBP/p300 bromodomains, enhances acetylation by p300.
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| Molecular Weight (g/mol) | 468.59 |
|---|---|
| Color | Light Yellow |
| Physical Form | Solid |
| Chemical Name or Material | I-CBP112 |
| Grade | Research |
| SMILES | COC1=C(OC)C=C(C2=CC(OC[C@H]3CCCN(C)C3)=C(OCCN(C(CC)=O)C4)C4=C2)C=C1 |
| For Use With (Application) | Cancer-programmed cell death |
| Percent Purity | 98.46% |
| CAS | 1640282-31-0 |
| Solubility Information | DMSO : ≥ 32 mg/mL (68.29 mM) |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C27H36N2O5 |
| Formula Weight | 468.59 |
I-BET151, MedChemExpress
MedChemExpress I-BET151 (GSK1210151A) is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively.
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| Molecular Weight (g/mol) | 415.44 |
|---|---|
| Color | White |
| Physical Form | Solid |
| Chemical Name or Material | I-BET151 |
| Grade | Research |
| SMILES | C[C@@H](N1C(C(C=C(OC)C(C2=C(C)ON=C2C)=C3)=C3N=C4)=C4NC1=O)C5=CC=CC=N5 |
| For Use With (Application) | Cancer-programmed cell death |
| Percent Purity | 98.08% |
| CAS | 1300031-49-5 |
| Solubility Information | DMSO : ≥ 100 mg/mL (240.71 mM) |
| Health Hazard 1 | H301 |
| Synonym | GSK1210151A |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C23H21N5O3 |
| Formula Weight | 415.44 |
I-BET762 carboxylic acid, MedChemExpress
MedChemExpress I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1.
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| Molecular Weight (g/mol) | 396.83 |
|---|---|
| Color | Light Yellow |
| Physical Form | Solid |
| Chemical Name or Material | I-BET762 carboxylic acid |
| Grade | Research |
| SMILES | CC1=NN=C2[C@H](CC(O)=O)N=C(C3=CC=C(Cl)C=C3)C4=C(C=CC(OC)=C4)N21 |
| For Use With (Application) | Cancer-programmed cell death |
| Percent Purity | 98.64% |
| CAS | 1300019-38-8 |
| Solubility Information | DMSO : 7.14 mg/mL (17.99 mM; Need ultrasonic) |
| Synonym | Molibresib carboxylic acid GSK525762A carboxylic acid PROTAC BRD4-binding moiety 2 |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C20H17ClN4O3 |
| Formula Weight | 396.83 |
Molibresib, MedChemExpress
MedChemExpress Molibresib (I-BET762; GSK525762) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.
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| Molecular Weight (g/mol) | 423.9 |
|---|---|
| Color | Light Yellow |
| Physical Form | Solid |
| Chemical Name or Material | Molibresib |
| Grade | Research |
| SMILES | ClC1=CC=C(C2=N[C@@H](CC(NCC)=O)C3=NN=C(C)N3C4=CC=C(OC)C=C24)C=C1 |
| For Use With (Application) | Cancer-programmed cell death |
| Percent Purity | 98.53% |
| CAS | 1260907-17-2 |
| Solubility Information | DMSO : 200 mg/mL (471.81 mM; Need ultrasonic) |
| Synonym | I-BET762 GSK525762 GSK525762A |
| Purity Grade Notes | Research |
| Recommended Storage | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Shelf Life | Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month |
| Molecular Formula | C22H22ClN5O2 |
| Formula Weight | 423.9 |
Aristolochic acid A, MedChemExpress
MedChemExpress Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines.
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| Molecular Weight (g/mol) | 341.27 |
|---|---|
| Color | Yellow |
| Physical Form | Solid |
| Chemical Name or Material | Aristolochic acid A |
| Grade | Research |
| SMILES | OC(C1=CC2=C(OCO2)C3=C4C(C(OC)=CC=C4)=CC([N+]([O-])=O)=C31)=O |
| For Use With (Application) | Cancer-programmed cell death |
| Percent Purity | 98.52% |
| CAS | 313-67-7 |
| Solubility Information | DMSO : 25 mg/mL (73.26 mM; Need ultrasonic) |
| Health Hazard 1 | H301∣H340∣H350 |
| Synonym | Aristolochic acid I TR 1736 |
| Purity Grade Notes | Research |
| Recommended Storage | 4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light) |
| Shelf Life | 4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light) |
| Molecular Formula | C17H11NO7 |
| Formula Weight | 341.27 |
Gallamine Triethiodide, MedChemExpress
MedChemExpress Gallamine Triethiodide is a synthetic nondepolarizing blocking drug.
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