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Pyrazines

Aromatic organic heterocyclic compounds that consist of a six-membered ring with four carbon atoms and two nitrogen atoms at opposite positions of the ring, making this ring symmetrical.

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1

Caficrestat, MedChemExpress

MedChemExpress Caficrestat (Aldose reductase-IN-1) is a inhibitor of aldose reductase with IC50 of 28.9 pM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 421.35
Color White
Physical Form Solid
Chemical Name or Material Caficrestat
Grade Research
SMILES O=C1C2=NC=CN=C2C(CC(O)=O)=NN1CC3=NC4=C(C=CC(C(F)(F)F)=C4)S3
For Use With (Application) Metabolism-sugar/lipid metabolism
Percent Purity 99.88%
CAS 1355612-71-3
Solubility Information DMSO : ≥ 28 mg/mL (66.45 mM)
Synonym Aldose reductase-IN-1 AT-001
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C17H10F3N5O3S
Formula Weight 421.35
2

Naquotinib mesylate, MedChemExpress

MedChemExpress Naquotinib mesylate (ASP8273 mesylate) is an orally available, mutant-selective and irreversible EGFR inhibitor; with IC50s of 8-33 nM toward EGFR mutants and 230 nM for EGFR.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 658.81
Color Yellow
Physical Form Solid
Chemical Name or Material Naquotinib mesylate
Grade Research
SMILES O=C(C1=NC(CC)=C(O[C@H]2CN(C(C=C)=O)CC2)N=C1NC3=CC=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)N.CS(=O)(O)=O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.02%
CAS 1448237-05-5
Solubility Information DMSO : 12.5 mg/mL (18.97 mM; Need ultrasonic and warming)
Synonym ASP8273 (mesylate)
Purity Grade Notes Research
Recommended Storage 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula C31H46N8O6S
Formula Weight 658.81
3

VE-821, MedChemExpress

MedChemExpress VE-821 is a potent ATP-competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 368.41
Color Green
Physical Form Solid
Chemical Name or Material VE-821
Grade Research
SMILES O=C(NC1=CC=CC=C1)C2=NC(C3=CC=C(C=C3)S(=O)(C)=O)=CN=C2N
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.94%
CAS 1232410-49-9
Solubility Information DMSO : 50 mg/mL (135.72 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C18H16N4O3S
Formula Weight 368.41