Invitrogen™ TUBA1B/TUBA4A Recombinant Rabbit Monoclonal Antibody (24GB2020)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA557300

Product Code. 30275288

Description

TUBA1B/TUBA4A Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow

TUBA1B and TUBA4A are genes that encode for alpha-tubulin isoforms, essential components of the microtubule system that plays a critical role in maintaining cell structure, intracellular transport, and cell division. TUBA1B, also known as tubulin alpha-1b chain, is located on chromosome 12q13.12 and has been linked to various cancers due to its influence on microtubule dynamics and cellular proliferation. It is also associated with immune cell infiltration and modulation of immune checkpoints, making it significant in tumor growth and metastasis. TUBA4A, known as tubulin alpha-4A, is found on chromosome 2q35 and is linked to neurodevelopmental disorders and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in TUBA4A can lead to defects in microtubule stability and function, emphasizing its role in neuronal health. Both genes highlight the critical role of microtubules in cellular and neurological functions, and their mutations can contribute to diverse pathological conditions, including cancer and neurodegenerative diseases.

Specifications

• Antigen: TUBA1B/TUBA4A
• Classification: Recombinant Monoclonal
• Conjugate: Unconjugated
• Gene: TUBA1B
• Gene Symbols: TUBA1B, TUBA4A
• Immunogen: A synthesized peptide derived from human TUBA1B/4A (aa 33-47).
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Clone: 24GB2020
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P05213, P68363, P68366, P68368, Q5XIF6, Q6P9V9
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10376, 22143, 22145, 316531, 500929, 7277
• Content And Storage: -20°C
• Form: Liquid