Thermo Scientific™ Trimethoprim

Product Code	Brand	Quantity
15445319	Thermo Scientific™ J63053.03	1 g
15455319	Thermo Scientific™ J63053.06	5 g
15465319	Thermo Scientific™ J63053.14	25 g

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• Trimethoprim is a synthetic pyrimidine analog that binds dihydrofolate-reductase and inhibits the synthesis of folic acid; when paired with sulfamethoxazole, its activity is enhanced

• Trimethoprim has antibacterial and antiprotozoal properties

Applications

• Trimethoprim inhibits the conversion of para-aminobenzoic acid (PABA) to folic acid near the end of the synthesis pathway and can be used to study related effects

• Trimethoprim has been radiolabeled and used to trace routes of infection, and it also has been used experimentally as a fluorescent labeler to quantify dihydrofolate-reductase expression

Chemical Identifiers

• CAS: 738-70-5
• Synonym: 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
• Format: Powder
• Description: White
• Solubility: Trimethoprim is soluble in water at 0.4 mg/ml; It is also soluble in DMSO at 50 mg/ml and chloroform at 18.2 mg/ml

• Formula Weight: 290.32g/mol
• Content And Storage: 2°C to 8°C
• For Use With (Application): An antibacterial and inhibitor of formylation. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme
• Melting Point: 199°C to 203°C

Specifications

• Description: White
• Format: Powder
• CAS: 738-70-5
• Formula Weight: 290.32g/mol
• Melting Point: 199°C to 203°C
• Beilstein: 625127

• Content And Storage: 2°C to 8°C
• For Use With (Application): An antibacterial and inhibitor of formylation. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme
• Molecular Formula: C₁₄H₁₈N₄O₃
• Synonym: 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
• Solubility: Trimethoprim is soluble in water at 0.4 mg/ml; It is also soluble in DMSO at 50 mg/ml and chloroform at 18.2 mg/ml

Safety and Handling

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Recommended Storage : Keep cold

Product Identifier

• Trimethoprim

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4

Hazard Statement

• H302-Harmful if swallowed.

Precautionary Statement

• P264-Wash face, hands and anyexposed skin thoroughly after handling.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contains : Trimethoprim

RUO – Research Use Only