TALPID3 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16882895	Proteintech 24421-1-AP-20UL	20 μL
16872895	Proteintech 24421-1-AP-150UL	150 μL

Description

KIAA0586 also named as Talpid3 is a 1472 amino-acid protein, which belongs to Talpid3 family. Talpid3 is a gene essential for vertebrate development. Studies in chicken, mouse, zebrafish and human have shown that TALPID3 is a centrosomal protein, mutants null for TALPID3 fail to produce cilia, resulting in far reaching signaling defects such as polydactyly, dorsalised neural tube, craniofacial and vascular defects often due to abnormalities in Hedgehog signal transduction. Talpid3 is absolutely required for the function of both Gli repressor and activator in the intracellular Hedgehog pathway and ciliogenesis. TALPID3 may be identified as a subcellular maker of centrosome and needed to further studied.

Specifications

• Antigen: TALPID3
• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Human
• Gene Accession No.: Q9BVV6
• Gene ID (Entrez): 9786
• Immunogen: TALPID3 Fusion Protein Ag19813
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: KIAA0586

• Concentration: 0.41 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: KIAA0586, KIAA0586 isoform, Talpid3
• Gene Symbols: KIAA0586
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody