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Survivin Ab-6, Rabbit Polyclonal Antibody,Lab Vision™ Epredia™
Provide accurate, reproducible results with the Epredia™ Survivin Ab-6, Rabbit Polyclonal Antibody.
Brand: Epredia RB-1629-P1ABX
This item is not returnable.
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Description
Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.Host Species: Rabbit
Isotype: IgG
Species Reactivity: Human and Mouse. Others not tested.
Epitope: C-terminal
Immunogen: A synthetic peptide derived from the C-terminus of survivin
Molecular Weight: 16.5kDa
Positive Control: Stomach
Cellular Localization: Cytoplasmic and Nuclear
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
Note:
USA: RUO; Int'l: RUO
Specifications
| Survivin Ab-6 | |
| Polyclonal | |
| Unconjugated | |
| Rabbit | |
| 500 μL | |
| Apoptosis | |
| Human | |
| IgG |
| Immunohistochemistry (Paraffin) | |
| 1mg/mL | |
| Purified w/o BSA and Azide | |
| A synthetic peptide derived from the C-terminus of survivin | |
| RUO | |
| Primary | |
| Concentrated |
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