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Tocris Bioscience™ SN 38
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Product Code. 18782664
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
Product Code. Quantity unitSize
18782664 10 mg 10mg
18742794 50 mg 50mg
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Product Code. 18782664

Brand: Tocris Bioscience™ 2684/10

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125.00 GBP valid until 2026-03-31
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This item is not returnable. View return policy

Description

DNA topoisomerase I inhibitor; antitumor

Active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 86639-52-3
Molecular Formula C22H20N2O5

Specifications

Quantity 10 mg
Formula Weight 392.4
Purity >98%
Molecular Weight (g/mol) 392.411
Chemical Name or Material SN 38
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