Securin / PTTG1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Produktcode	Marke	Quantity
16898074	Proteintech 18040-1-AP-20UL	20 μL
16888074	Proteintech 18040-1-AP-150UL	150 μL

Beschreibung

Pituitary tumor-transforming gene 1 (PTTG-1) is an oncogene expressed in normal tissues containing proliferating cells and in tumors. PTTG is downstream of the MAP kinase signaling cascade and is phosphorylated at Ser162 by MAPK in vitro. Phosphorylation plays an essential role in PTTG′s transactivation function. The PTTG protein contains a DNA-binding domain, and it activates transcription of the c-Myc oncogene by binding to the promoter to form a complex. Studies have demonstrated that expression of human PTTG correlates with cell proliferation in a cell cycle dependent manner, and the association of human PTTG with Ku, the regulatory subunit of DNA-dependent protein kinase, is disrupted when a DNA double-strand breaks occurs.

Spezifikation

• Antigen: Securin / PTTG1
• Applications: Immunofluorescence, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Rat, Human
• Gene Accession No.: O95997, P97613, Q9CQJ7
• Gene ID (Entrez): 30939, 64193, 9232
• Immunogen: Securin / PTTG1 Fusion Protein Ag12670
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: PTTG1

• Concentration: 0.38 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: EAP1, Esp1 associated protein, HPTTG, pituitary tumor transforming 1, PTTG, PTTG1, Securin, Tumor transforming protein 1, TUTR1
• Gene Symbols: Pttg1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody