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Thermo Scientific Chemicals SB 225002

Catalog Number 15496869
143.34 GBP valid until 2024-03-29
Use promo code "21615" to get your promotional price.


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Quantity:
5 mg
10 mg
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To receive the discount customers must purchase three of the same product at list price in a single order to receive 33.33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”21615” to get your promotional price
182498-32-4
C13H10BrN3O4
1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
This item is not returnable. View return policy
To receive the discount customers must purchase three of the same product at list price in a single order to receive 33.33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”21615” to get your promotional price
182498-32-4
C13H10BrN3O4
1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea

A potent, selective and competitive antagonist of the G-protein coupled receptor CXCR2

SB 225002 is a selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. In addition, SB 225002 reduces MPO activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels. Further studies suggest that SB 225002 decreases the expression of vascular endothelial growth factor, inducible NOS (NO synthase), and Cox-2 (cyclooxygenase-2 proteins) in colon tissue.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

TRUSTED_SUSTAINABILITY
Quantity 10 mg
Description Yellow
Content And Storage -30°C to -10°C
For Use With (Application) A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2
Formula Weight 352.10g/mol
Sensitivity Moisture Sensitive
Solubility Soluble to 100mM in DMSO and to 50mM in ethanol
Product Type Signal Transduction Reagent
Form Solid

RUO – Research Use Only

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