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  5. Tocris Bioscience™ (S)-Crizotinib, >98%

Tocris Bioscience™ (S)-Crizotinib, >98%
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Product Code. 30000947
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Product Code. 30000947 Supplier Tocris Bioscience™ Supplier No. 6025/10

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Description

MTH1 inhibitor

Potent MTH1 inhibitor (IC50 = 72 nM). Induces DNA damage and disrupts nucleotide pool homeostasis in cancer cells. Also attenuates colony formation of KRAS-mutated PANC1 cells in vitro. Suppresses tumor growth ∽50% in a colon cancer carcinoma xenograft model.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1374356-45-2
Molecular Formula C21H22Cl2FN5O

Specifications

Quantity 10 mg
Solubility Soluble to 50mM in DMSO and to 20mM in 1eq. HCl with gentle warming
Formula Weight 450.34
Purity >98%
Molecular Weight (g/mol) 450.339
Chemical Name or Material 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
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