RNF11 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16836744	Proteintech 16948-1-AP-20UL	20 μL
16826744	Proteintech 16948-1-AP-150UL	150 μL

Description

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates ′Lys-63′ polyubiquitin chains on RIPK1 and catalyzes the formation of ′Lys-48′-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Specifications

• Antigen: RNF11
• Applications: Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Rat, Mouse
• Gene Accession No.: Q9QYK7, Q9Y3C5
• Gene ID (Entrez): 26994, 29864, 689577
• Immunogen: RNF11 Fusion Protein Ag10563
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: RNF11

• Concentration: 0.17 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: CGI 123, ring finger protein 11, RNF11, SID1669
• Gene Symbols: Rnf11
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody