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  6. RNF11 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

RNF11 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16836744 Shop All Proteintech Products
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20 μL
150 μL
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150µL
20µL
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16836744 20 μL 20µL
16826744 150 μL 150µL
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Product Code. 16836744 Supplier Proteintech Supplier No. 169481AP20UL

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Description

Rabbit Polyclonal Antibody

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates ′Lys-63′ polyubiquitin chains on RIPK1 and catalyzes the formation of ′Lys-48′-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Specifications

Antigen RNF11
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.17 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene RNF11
Gene Accession No. Q9QYK7, Q9Y3C5
Gene Alias CGI 123, ring finger protein 11, RNF11, SID1669
Gene Symbols Rnf11
Host Species Rabbit
Immunogen RNF11 Fusion Protein Ag10563
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26994, 29864, 689577
Target Species Human, Rat, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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