Retinoic acid, 97%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11485290	Thermo Scientific Alfa Aesar 044540.77	0.1 g
11465290	Thermo Scientific Alfa Aesar 044540.02	0.5 g
11475290	Thermo Scientific Alfa Aesar 044540.04	2 g

Description

Retinoic acid is used in dermatology drugs. It is used in the treatment of psoriasis, ichthyosis, follicular keratosis, acne, lichen planus, verrucous epidermal nevus and lichen psoriasis. It is also employed in promoting the proliferation and differentiation of epithelial cells. In addition to this, it exhibits some preventive effect on skin cancer.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• All-trans-retinol, commonly known as Vitamin A, is a fat-soluble essential nutrient

• All-trans-retinol is involved in hormonal signaling via the retinoid receptors

• It is an important regulator of cell division and apoptosis

• Deficiency can lead to vision, bone, immune, and skin disorders

Applications

• Suitable for research on cell differentiation, embryonic development, immunology and more

• Laboratory grade quality, for research use only

Chemical Identifiers

• CAS: 302-79-4
• Molecular Weight (g/mol): 300.44
• InChI Key: SHGAZHPCJJPHSC-YCNIQYBTSA-N
• PubChem CID: 444795
• SMILES: C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O

• Molecular Formula: C20H28O2
• MDL Number: MFCD00001551
• Synonym: retinoic acid, tretinoin, vitamin a acid, all-trans-retinoic acid, trans-retinoic acid, renova, airol, retin-a, vesanoid, atra
• ChEBI: CHEBI:15367

Specifications

• CAS: 302-79-4
• Molecular Formula: C20H28O2
• Beilstein: 2057223
• Merck Index: 14,8165
• Solubility Information: Soluble in ethanol,acetate,dimethyl formamide,dimethyl sulfoxide,chloroform,methanol,acetone and dichloromethane. Insoluble in water and ether.
• SMILES: C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
• Molecular Weight (g/mol): 300.44
• ChEBI: CHEBI:15367
• Percent Purity: 98%
• Chemical Name or Material: Retinoic acid

• Melting Point: 180°C to 182°C
• MDL Number: MFCD00001551
• Sensitivity: Light sensitive
• Synonym: retinoic acid, tretinoin, vitamin a acid, all-trans-retinoic acid, trans-retinoic acid, renova, airol, retin-a, vesanoid, atra
• InChI Key: SHGAZHPCJJPHSC-YCNIQYBTSA-N
• IUPAC Name: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
• PubChem CID: 444795
• Formula Weight: 300.44
• Physical Form: Crystalline

Safety and Handling

GHS H Statement
H361-H302
Suspected of damaging fertility or the unborn child.
Harmful if swallowed.

P201-P202-P261-P264b-P270-P271-P280-P281-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P312-P330-P332+P313-P362-P501c

H302+H312-H315-H319-H335-H361

missing translation for 'einecsNumber' : 206-129-0

missing translation for 'rtecsNumber' : VH6475000

missing translation for 'tsca' : Yes

Recommended Storage : Ambient temperatures

Product Identifier

• Retinoic acid

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 2
• Reproductive toxicity Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H302-Harmful if swallowed.
• H312-Harmful in contact with skin.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.
• H361d-Suspected of damaging the unborn child.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contains : all-trans-Retinoic acid

RUO – Research Use Only